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Featured researches published by Karel Pacak.


Nuclear Medicine and Biology | 2012

Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma

Lucia Martiniova; Susannah Cleary; Edwin W. Lai; Dale O. Kiesewetter; Jurgen Seidel; Linda F. Dawson; Jacqueline K. Phillips; David Thomasson; Xiaoyuan Chen; Graeme Eisenhofer; James F. Powers; Richard Kvetnansky; Karel Pacak

PURPOSE To evaluate the usefulness of [(18)F]-6-fluorodopamine ([(18)F]-DA) and [(18)F]-L-6-fluoro-3,4-dihydroxyphenylalanine ([(18)F]-DOPA) positron emission tomography (PET) in the detection of subcutaneous (s.c.) and metastatic pheochromocytoma in mice; to assess the expression of the norepinephrine transporter (NET) and vesicular monoamine transporters 1 and 2 (VMAT1 and VMAT2), all important for [(18)F]-DA and [(18)F]-DOPA uptake. Furthermore, to compare tumor detection by micro-computed tomography (microCT) to magnetic resonance imaging (MRI) in individual mouse. METHODS SUV(max) values were calculated from [(18)F]-DA and [(18)F]-DOPA PET, tumor-to-liver ratios (TLR) were obtained and expression of NET, VMAT1 and VMAT2 was evaluated. RESULTS [(18)F]-DA detected less metastatic lesions compared to [(18)F]-DOPA. TLR values for liver metastases were 2.26-2.71 for [(18)F]-DOPA and 1.83-2.83 for [(18)F]-DA. A limited uptake of [(18)F]-DA was found in s.c. tumors (TLR = 0.22-0.27) compared to [(18)F]-DOPA (TLR = 1.56-2.24). Overall, NET and VMAT2 were expressed in all organ and s.c. tumors. However, s.c. tumors lacked expression of VMAT1. We confirmed [(18)F]-DAs high affinity for the NET for its uptake and VMAT1 and VMAT2 for its storage and retention in pheochromocytoma cell vesicles. In contrast, [(18)F]-DOPA was found to utilize only VMAT2. CONCLUSION MRI was superior in the detection of all organ tumors compared to microCT and PET. [(18)F]-DOPA had overall better sensitivity than [(18)F]-DA for the detection of metastases. Subcutaneous tumors were localized only with [(18)F]-DOPA, a finding that may reflect differences in expression of VMAT1 and VMAT2, perhaps similar to some patients with pheochromocytoma where [(18)F]-DOPA provides better visualization of lesions than [(18)F]-DA.


18th European Congress of Endocrinology | 2016

Synergistic anti-tumour effects of 13-cis retinoic acid and lovastatin in pancreatic neuroendocrine tumour (BON1) cells through enhanced EGFR inhibition

Svenja Nölting; Elke Tatjana Aristizabal Prada; Michael Lauseker; Julian Maurer; Gerald Spöttl; Burkhard Göke; Karel Pacak; Ashley B. Grossman

Svenja Nlting DOI: 10.3252/pso.eu.18ECE.2016 Endocrine tumours and neoplasia Synergistic anti-tumour effects of 13-cis retinoic acid and lovastatin in pancreatic neuroendocrine tumour (BON1) cells through enhanced EGFR inhibition CAMPUS GROSSHADERN MED. II AG DR. SVENJA NÖLTING / PROF. DR. AUERNHAMMER INTERDISCIPLINARY CENTER FOR NEUROENDOCRINE TUMORS OF THE GASTROENTEROPANCREATIC SYSTEM (GEPNET-KUM )


Archive | 2008

Clinical Presentation of Pheochromocytoma

Karel Pacak; Jacques W. M. Lenders; Graeme Eisenhofer


Archive | 2009

Overview of Endocrine Hypertension

Karel Pacak; Christian A. Koch; Marion R Wofford; Alejandro R. Ayala


Archive | 2008

Current Trends in Biochemical Diagnosis of Pheochromocytoma

Karel Pacak; Jacques W. M. Lenders; Graeme Eisenhofer


Endocrinology: Adult and Pediatric (Seventh Edition) | 2016

Chapter 110 – Pheochromocytoma

Karel Pacak; Henri Timmers; Graeme Eisenhofer


Archive | 2008

Current Trends in Genetics of Pheochromocytoma

Karel Pacak; Jacques W. M. Lenders; Graeme Eisenhofer


Archive | 2008

Catecholamines and Adrenergic Receptors

Karel Pacak; Jacques W. M. Lenders; Graeme Eisenhofer


Archive | 2008

Current Trends in Localization of Pheochromocytoma

Karel Pacak; Jacques W. M. Lenders; Graeme Eisenhofer


19th European Congress of Endocrinology | 2017

Role of microenvironment on metabolic control of murine pheochromocytoma SDHB silenced cells

Susan Richter; Serena Martinelli; Letizia Canu; Tonino Ercolino; Graeme Eisenhofer; Karel Pacak; Elena Rapizzi; Massimo Mannelli

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Graeme Eisenhofer

Dresden University of Technology

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Jacques W. M. Lenders

Dresden University of Technology

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Henri Timmers

Radboud University Nijmegen

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Susan Richter

Dresden University of Technology

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Christian A. Koch

National Institutes of Health

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Jacques W.M. Lenders

National Institutes of Health

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Karen T. Adams

National Institutes of Health

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Lucia Martiniova

National Institutes of Health

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