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Dive into the research topics where Karen Chapman is active.

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Featured researches published by Karen Chapman.


Journal of Biological Chemistry | 2000

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways.

Louise J. S. Williams; Val Lyons; Iolaina MacLeod; Vidya Rajan; Gretchen J. Darlington; Valeria Poli; Jonathan Seckl; Karen Chapman

Glucocorticoid action within individual cells is potently modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD), which, by interconverting active and inert glucocorticoids, determines steroid access to receptors. Type 1 11β-HSD (11β-HSD1) is highly expressed in liver where it regenerates glucocorticoids, thus amplifying their action and contributing to induction of glucocorticoid-responsive genes, most of which are also regulated by members of the C/EBP (CAAT/enhancer-binding protein) family of transcription factors. Here we demonstrate that C/EBPα is a potent activator of the 11β-HSD1 gene in hepatoma cells and that mice deficient in C/EBPα have reduced hepatic 11β-HSD1expression. In contrast, C/EBPβ is a relatively weak activator of 11β-HSD1 transcription in hepatoma cells and attenuates C/EBPα induction, and mice that lack C/EBPβ have increased hepatic 11β-HSD1 mRNA. The 11β-HSD1promoter (between −812 and +76) contains 10 C/EBP binding sites, and mutation of the promoter proximal sites decreases the C/EBP inducibility of the promoter. One site encompasses the transcription start, and both C/EBPα and C/EBPβ are present in complexes formed by liver nuclear proteins at this site. The regulation of 11β-HSD1 expression, and hence intracellular glucocorticoid levels, by members of the C/EBP family provides a novel mechanism for cross-talk between the C/EBP family of transcription factors and the glucocorticoid signaling pathway.


Archive | 2003

Regulation of glucocorticoid concentration

Brian R. Walker; Jonathan Seckl; John Savill; Jamie Gilmour; Karen Chapman


Society for Endocrinology BES 2012 | 2012

Maturational effects of glucocorticoids on fetal cardiomyocytes are direct and mediated by glucocorticoid receptor

Eva A. Rog-Zielinska; Chris Kenyon; Megan C. Holmes; Karen Chapman


Society for Endocrinology BES 2011 | 2011

Impaired cardiac function in GR-/- fetal mice

Eva A. Rog-Zielinska; Adrian Thomson; Carmel Moran; David Brownstein; Christopher J. Kenyon; Zoi Michailidou; Dorota Szumska; S Bhattacharya; Jennifer Richardson; Elizabeth Owen; Alistair J. Watt; Lesley M. Forrester; Megan C. Holmes; Karen Chapman


Archive | 2000

C/EBP Regulates Hepatic Transcription of 11b-Hydroxysteroid Dehydrogenase Type 1

Louise J. S. Williams; Val Lyons; Iolaina MacLeod; Vidya Rajan; Gretchen J. Darlington; Valeria Polii; Jonathan Seckl; Karen Chapman


20th European Congress of Endocrinology | 2018

Investigating glucocorticoids as mediators of increased bone marrow adiposity during caloric restriction

Andrea Lovdel; Karla Suchacki; Richard J. Sulston; Robert Wallace; Gavin Macpherson; Roland H. Stimson; Natalie Homer; Karen Chapman; William P. Cawthorn


Society for Endocrinology BES 2017 | 2017

Do glucocorticoids cause mitochondrial substrate switching in fetal cardiomyocytes

Jessica R. Ivy; Emma Batchen; Roderick N. Carter; Nicholas Morton; Karen Chapman


Society for Endocrinology BES 2016 | 2016

11[beta]-HSD1 deficiency modulates brain energy homeostasis during acute systemic inflammation

Manu Verma; Tiina Kipari; Tak Yung Man; Thorsten Forster; Natalie Homer; Jonathan Seckl; Megan C. Holmes; Karen Chapman


Society for Endocrinology BES 2016 | 2016

Does precocious dexamethasone treatment advance fetal cardiac maturation

Emma Batchen; Rachel Richardson; Adrian Thomson; Carmel Moran; Karen Sooy; Natalie Homer; Gillian A. Gray; Karen Chapman


Society for Endocrinology BES 2015 | 2015

Maternal genotype is an important determinant of the outcome of antenatal glucocorticoid treatment in GR+/+ and GR+/− foetal mice

Emma Batchen; Rachel Richardson; Adrian Thomson; Carmel Moran; Gillian A. Gray; Karen Chapman

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Jonathan Seckl

Baylor College of Medicine

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Patrick Hadoke

Western General Hospital

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Carmel Moran

University of Edinburgh

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Emma Batchen

University of Edinburgh

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John Savill

University of Edinburgh

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