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Dive into the research topics where Karen Heyninck is active.

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Featured researches published by Karen Heyninck.


FEBS Letters | 1996

A20, an inhibitor of cell death, self-associates by its zinc finger domain.

Dirk De Valck; Karen Heyninck; Wim Van Criekinge; Roland Contreras; Rudi Beyaert; Walter Fiers

A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells. The A20 protein belongs to a novel class of Cys2/Cys2 zinc finger proteins, and has been characterized as an inhibitor of both apoptotic and necrotic cell death. In order to clarify its molecular mechanism of action, we used the yeast‐based‐two‐hybrid system to screen for A20‐associated proteins. Here we report that A20 is able to self‐associate, and demonstrate that the latter interaction is mediated by its zinc finger domain.


Journal of Inflammation | 1995

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis

Walter Fiers; R. Beyaert; Elke Boone; Sigrid Cornelis; Wim Declercq; Els Decoster; Geertrui Denecker; B. Depuydt; D. De Valck; G. De Wilde; Vera Goossens; Johan Grooten; Guy Haegeman; Karen Heyninck; Louis C. Penning; Stéphane Plaisance; Katia Vancompernolle; W. Van Criekinge; Peter Vandenabeele; W. Vanden Berghe; M. Van De Craen; Veronique Vandevoorde; Dominique Vercammen


Biochemical and Biophysical Research Communications | 1997

A20 Inhibits NF-κB Activation Independently of Binding to 14-3-3 Proteins

Dirk De Valck; Karen Heyninck; Wim Van Criekinge; Peter Vandenabeele; Walter Fiers; Rudi Beyaert


Journal of Immunology | 1993

Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.

R. Beyaert; Karen Heyninck; D. De Valck; F Boeykens; F. Van Roy; Walter Fiers


Archive | 2003

Novel inhibitors of NF-kappaB activation

Rudi Beyaert; Karen Heyninck; Walter Fiers


Archive | 2003

Inhibitors of NF-kappaB activation

Rudi Beyaert; Karen Heyninck; Walter Fiers


Archive | 2004

Inhibitors of NF-&kgr B Activation

Rudi Beyaert; Karen Heyninck; Walter Fiers


Archive | 1999

Inhibitors of nf-kb activation

Rudi Beyaert; Karen Heyninck; Walter Fiers


Archive | 1999

Inhibitoren der nf-kb aktivierung Inhibitors of nf-kb activation

Rudi Beyaert; Walter Fiers; Karen Heyninck


Archive | 1999

NOUVEAUX INHIBITEURS D'ACTIVATION NF-λB

Rudi Beyaert; Karen Heyninck; Walter Fiers

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Rudi Beyaert

Laboratory of Molecular Biology

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Walter Fiers

St. Jude Children's Research Hospital

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Walter Fiers

St. Jude Children's Research Hospital

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D. De Valck

Laboratory of Molecular Biology

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Dirk De Valck

Laboratory of Molecular Biology

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Wim Van Criekinge

Laboratory of Molecular Biology

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R. Beyaert

St. Jude Children's Research Hospital

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Dominique Vercammen

Laboratory of Molecular Biology

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Els Decoster

Laboratory of Molecular Biology

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