Karen K. Lindfors
Harvard University
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Featured researches published by Karen K. Lindfors.
Journal of Computer Assisted Tomography | 1986
Jack E. Meyer; R Oot; Karen K. Lindfors
Computed tomography of 30 patients with chordomas arising from the clivus was reviewed. All examinations demonstrated bone destruction with a soft tissue mass and varying degrees of encroachment on the adjacent brain. Other CT findings included contrast enhancement, soft tissue calcification and well defined areas of low attenuation.
Cancer | 1987
Christopher G. Willett; Rita M. Linggood; Jack E. Meyer; Erica Orlow; Karen K. Lindfors; Karen P. Doppke; Alan C. Aisenberg
This study analyzed the 5 year actuarial survival and disease‐free survival of 122 patients with Stage IA and IIA Hodgkins disease, (108 patients laparotomy staged) treated with mantle and paraaortic irradiation from 1975 to 1981. Prognostic subgroups and patterns of treatment failure were investigated. The 5 year actuarial survival and disease‐free survival was 91% and 75% respectively for the entire group. For Stage IA patients, the 5 year survival and disease‐free survival was 92% and 86% respectively, whereas for those in Stage IIA the respective figures were 86% and 65%. Individuals with greater than four sites of involvement at initial presentation; extensive mediastinal adenopathy; hilar or extramediastinal extension to lung, pleura or pericardium, had a poorer 5 year actuarial disease‐free survival (43%–60%) than those without these factors (70%–85%). Of the 122 patients, there were 26 relapses: nine infield failures; two concurrent infield and systemic failures; nine marginal recurrences, and three relapses occuring systemically and three in nodal groups not irradiated. Following relapse, 17 patients were salvaged with chemotherapy. Two patients are alive with disease and seven patients died of Hodgkins disease. Patients with less extensive mediastinal adenopathy and supradiaphragmatic nonmediastinal presentations can be satisfactorily treated with mantle and paraaortic irradiation, whereas patients with extensive mediastinal adenopathy receive six cycles of multiagent chemotherapy before irradiation. Cancer 59:1107‐1111, 1987.
Journal of Computer Assisted Tomography | 1985
Jack E. Meyer; Theresa C. McLoud; Karen K. Lindfors
Eleven patients with Hodgkin disease involving the cardiophrenic angle lymph nodes are described. Four were discovered at the time of initial staging, and the remainder represented a major site of relapse after therapy. Regression of adenopathy after chemotherapy was documented in six patients; surgical excision (three), biopsy (one) and postmortem examination confirmed the presence of recurrent disease in the remaining cases. Enlargement of cardiophrenic angle nodes was frequently overlooked on conventional chest radiography, but a rather typical appearance is readily identifiable on CT.
Journal of Computer Assisted Tomography | 1984
Jack E. Meyer; Rita M. Linggood; Karen K. Lindfors; Theresa C. McLoud; Paul C. Stomper
Over 5 years, CT of the thorax was performed on 53 patients with Hodgkin disease and mediastinal lymphadenopathy prior to the institution of therapeutic irradiation. Information obtained from CT prompted major alterations in the plan of therapy in 11 of 53 (21%) of the patients. These included changes of treatment portal size, the addition of localized boost therapy, and a revision of diagnosis.
Cancer | 1987
Christopher G. Willett; Rita M. Linggood; Jack E. Meyer; Erica Orlow; Karen K. Lindfors; Karen P. Doppke; Alan C. Aisenberg
From 1975 to 1981, 38 patients with Stage 3A Hodgkins disease (35 patients pathologically staged) underwent mantle and para‐aortic irradiation, and in 36 patients this was preceded or followed by at least six cycles of multiagent chemotherapy. Both the 5‐year actuarial survival and disease‐free survival for all 38 patients were 83%. There have been six treatment failures: two patients have relapsed within irradiated nodal groups, one patient in apical pericardial lymph nodes as a marginal recurrence, one patient concurrently infield and in unirradiated nodal groups, and two patients systemically (concurrently in unirradiated nodal groups). Of these six relapses, three patients have died of Hodgkins disease, one patient has been salvaged, and two patients currently are under treatment for salvage. One patient has developed acute nonlymphocytic leukemia and died of this disease. Extensive disease, as estimated by the number of sites of involvement at presentation, degree of splenic involvement, extent of intra‐abdominal disease or mediastinal involvement, did not reveal statistically significant prognostic subgroups for relapse. It is currently recommended that patients with Stage 3A Hodgkins disease receive six cycles of multiagent chemotherapy and mantle and para‐aortic irradiation. Cancer 59:27–30, 1987.
Radiology | 1985
Daniel B. Kopans; Karen K. Lindfors; Kathleen A. McCarthy; Jack E. Meyer
Radiology | 1984
Jack E. Meyer; Daniel B. Kopans; Paul C. Stomper; Karen K. Lindfors
Radiology | 1985
Daniel B. Kopans; Jack E. Meyer; Karen K. Lindfors
Radiology | 1989
Jack E. Meyer; E Amin; Karen K. Lindfors; J C Lipman; Paul C. Stomper; D Genest
Radiology | 1984
Jack E. Meyer; R A Lepke; Karen K. Lindfors; J J Pagani; J C Hirschy; L A Hayman; K J Momose; B McGinnis