Karen Messer

A Nationwide Analysis of US Racial/Ethnic Disparities in Smoking Behaviors, Smoking Cessation, and Cessation-Related Factors

OBJECTIVES We used nationally representative data to examine racial/ethnic disparities in smoking behaviors, smoking cessation, and factors associated with cessation among US adults. METHODS We analyzed data on adults aged 20 to 64 years from the 2003 Tobacco Use Supplement to the Current Population Survey, and we examined associations by fitting adjusted logistic regression models to the data. RESULTS Compared with non-Hispanic Whites, smaller proportions of African Americans, Asian Americans/Pacific Islanders, and Hispanics/Latinos had ever smoked. Significantly fewer African Americans reported long-term quitting. Racial/ethnic minorities were more likely to be light and intermittent smokers and less likely to smoke within 30 minutes of waking. Adjusted models revealed that racial/ethnic minorities were not less likely to receive advice from health professionals to quit smoking, but they were less likely to use nicotine replacement therapy. CONCLUSIONS Specific needs and ideal program focuses for cessation may vary across racial/ethnic groups, such that approaches tailored by race/ethnicity might be optimal. Traditional conceptualizations of cigarette addiction and the quitting process may need to be revised for racial/ethnic minority smokers.

Smoking Cessation Rates in the United States: A Comparison of Young Adult and Older Smokers

OBJECTIVES We compared smoking quit rates by age in a nationally representative sample to determine differences in cessation rates among younger and older adults. METHODS We used data on recent dependent smokers aged 18 to 64 years from the 2003 Tobacco Use Supplement to the Current Population Survey (n=31625). RESULTS Young adults (aged 18-24 years) were more likely than were older adults (aged 35-64 years) to report having seriously tried to quit (84% vs 66%, P<.01) and to have quit for 6 months or longer (8.5% vs 5.0%, P<.01). Among those who seriously tried to quit, a smoke-free home was associated with quitting for 6 months or longer (odds ratio [OR]=4.13; 95% confidence interval [CI]=3.25, 5.26). Compared with older smokers, young adults were more likely to have smoke-free homes (43% vs 30%, P<.01), were less likely to use pharmaceutical aids (9.8% vs 23.7%, P<.01), and smoked fewer cigarettes per day (13.2% vs 17.4%, P<.01). CONCLUSIONS Young adults were more likely than were older adults to quit smoking successfully. This could be explained partly by young adults, more widespread interest in quitting, higher prevalence of smoke-free homes, and lower levels of dependence. High cessation rates among young adults may also reflect changing social norms.

Intermittent and light daily smoking across racial/ethnic groups in the United States

INTRODUCTION Limited research exists examining the prevalence of intermittent (nondaily) and light daily (1-5 cigarettes/day) smoking across racial/ethnic groups in the United States using nationally representative data. These analyses would be informative in guiding targeted cessation strategies. METHODS Using logistic regression models controlling for age, gender, and education, we examined the prevalence of intermittent and light daily consumption among current smokers across racial/ethnic groups from the 2003 Tobacco Use Supplement to the Current Population Survey. We also examined the association of these demographic factors with consumption within each racial/ethnic group separately. RESULTS Black (odds ratio [OR] = 1.82, 95% CI = 1.59-2.07), Asian/Pacific Islander (OR = 1.62, 95% CI = 1.29-2.04), and Hispanic/Latino (OR = 3.2, 95% CI = 2.75-3.74) smokers were more likely to smoke intermittently compared with non-Hispanic Whites. Black (OR = 2.69, 95% CI = 2.27-3.18), Asian/Pacific Islander (OR = 2.99, 95% CI = 2.13-4.19), and Hispanic/Latino (OR = 4.64, 95% CI = 3.85-5.58) smokers also were more likely to have light daily consumption compared with non-Hispanic Whites. Hispanic/Latino intermittent smokers smoked fewer days per month and fewer cigarettes per day compared with non-Hispanic White smokers. We found no significant gender differences across racial/ethnic groups in intermittent smoking, but male smokers were significantly less likely to have light daily consumption for all racial/ethnic groups. DISCUSSION These results have implications for the understanding of the tobacco dependence, the development of prevention and cessation strategies, and the applicability of harm-reduction techniques for racial/ethnic minorities.

The effect of smoke-free homes on adult smoking behavior: A review

INTRODUCTION Smoke-free homes are known to reduce exposure to harmful secondhand smoke. Recent studies suggest that they may also positively affect smoking behavior among smokers themselves. METHODS We review the literature on the effect of smoke-free homes on adult smoking behavior. The literature search included database (PubMed) and manual searches of related articles and reference lists for English-language studies published from 1 January 1990 to 16 November 2008. RESULTS We identified 16 cross-sectional and 7 longitudinal studies of the population-level association of smoke-free homes with adult smoking behavior. Additional studies provided population estimates of trends in and correlates of smoke-free homes. Prevalence of smoke-free homes varies but has been increasing over time in the countries studied and was greater among smokers who were younger, of higher income or educational attainment, smoked fewer cigarettes per day, or lived with a nonsmoking adult or child. Both longitudinal and cross-sectional studies showed that smokers who had or who newly implemented a smoke-free home were significantly more likely to make a quit attempt and to be abstinent, after controlling for confounding factors. In longitudinal studies, those who continued to smoke had a modest, but significant, decrease in cigarette consumption at follow-up. DISCUSSION There is strong and consistent population-level evidence that a smoke-free home is associated with increased smoking cessation and decreased cigarette consumption in adult smokers. As they not only reduce exposure to secondhand smoke but also increase cessation rates, promotion of smoke-free homes should be a key element in tobacco control programs.

Receptivity to Tobacco Advertising and Promotions Among Young Adolescents as a Predictor of Established Smoking in Young Adulthood

OBJECTIVES We investigated whether receptivity to tobacco advertising and promotions during young adolescence predicts young adult smoking 6 years later. METHODS Two longitudinal cohorts of adolescents drawn from the 1993 and 1996 versions of the California Tobacco Surveys were followed 3 and 6 years later. At baseline, adolescents were aged 12 to 15 years and were not established smokers. The outcome measure was established smoking at final follow-up. Receptivity to cigarette advertising and promotions was included in a multivariate logistic regression analysis along with demographic and other variables. RESULTS The rate of established smoking at follow-up was significantly greater among members of the 1993 through 1999 cohort (21.0%) than among members of the 1996 through 2002 cohort (15.6%). However, in both cohorts, having a favorite cigarette advertisement and owning or being willing to use a tobacco promotional item showed nearly identical adjusted odds of future adult smoking (1.46 and 1.84, respectively). CONCLUSIONS Despite the success of tobacco control efforts in reducing youth smoking, tobacco marketing remains a potent influence on whether young adolescents become established smokers in young adulthood (18-21 years of age).

PI3Kγ is a molecular switch that controls immune suppression

Macrophages play critical, but opposite, roles in acute and chronic inflammation and cancer. In response to pathogens or injury, inflammatory macrophages express cytokines that stimulate cytotoxic T cells, whereas macrophages in neoplastic and parasitic diseases express anti-inflammatory cytokines that induce immune suppression and may promote resistance to T cell checkpoint inhibitors. Here we show that macrophage PI 3-kinase γ controls a critical switch between immune stimulation and suppression during inflammation and cancer. PI3Kγ signalling through Akt and mTor inhibits NFκB activation while stimulating C/EBPβ activation, thereby inducing a transcriptional program that promotes immune suppression during inflammation and tumour growth. By contrast, selective inactivation of macrophage PI3Kγ stimulates and prolongs NFκB activation and inhibits C/EBPβ activation, thus promoting an immunostimulatory transcriptional program that restores CD8+ T cell activation and cytotoxicity. PI3Kγ synergizes with checkpoint inhibitor therapy to promote tumour regression and increased survival in mouse models of cancer. In addition, PI3Kγ-directed, anti-inflammatory gene expression can predict survival probability in cancer patients. Our work thus demonstrates that therapeutic targeting of intracellular signalling pathways that regulate the switch between macrophage polarization states can control immune suppression in cancer and other disorders.

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part, through the alternative splicing of self-renewal and survival genes. To elucidate splice-isoform regulators of human BC LSC maintenance, we performed whole-transcriptome RNA sequencing, splice-isoform-specific quantitative RT-PCR (qRT-PCR), nanoproteomics, stromal coculture, and BC LSC xenotransplantation analyses. Cumulatively, these studies show that the alternative splicing of multiple prosurvival BCL2 family genes promotes malignant transformation of myeloid progenitors into BC LSCS that are quiescent in the marrow niche and that contribute to therapeutic resistance. Notably, sabutoclax, a pan-BCL2 inhibitor, renders marrow-niche-resident BC LSCs sensitive to TKIs at doses that spare normal progenitors. These findings underscore the importance of alternative BCL2 family splice-isoform expression in BC LSC maintenance and suggest that the combinatorial inhibition of prosurvival BCL2 family proteins and BCR-ABL may eliminate dormant LSCs and obviate resistance.

Prevalence of heavy smoking in California and the United States, 1965-2007

CONTEXT The intensity of smoking, not just prevalence, is associated with future health consequences. OBJECTIVE To estimate smoking intensity patterns over time and by age within birth cohorts for California and the remaining United States. DESIGN, SETTING, AND PARTICIPANTS Two large population-based surveys with state estimates: National Health Interview Surveys, 1965-1994; and Current Population Survey Tobacco Supplements, 1992-2007. There were 139,176 total respondents for California and 1,662,353 for the remaining United States. MAIN OUTCOME MEASURE Number of cigarettes smoked per day (CPD), high-intensity smokers (≥20 CPD); moderate-intensity smokers (10-19 CPD); low-intensity smokers (0-9 CPD). RESULTS In 1965, 23.2% of adults in California (95% confidence interval [CI], 19.6%-26.8%) and 22.9% of adults in the remaining United States (95% CI, 22.1%-23.6%) were high-intensity smokers, representing 56% of all smokers. By 2007, this prevalence was 2.6% (95% CI, 0.0%-5.6%) or 23% of smokers in California and 7.2% (95% CI, 6.4%-8.0%) or 40% of smokers in the remaining United States. Among individuals (US residents excluding California) born between 1920-1929, the prevalence of moderate/high-intensity smoking (≥10 CPD) was 40.5% (95% CI, 38.3%-42.7%) in 1965. Moderate/high-intensity smoking declined across successive birth cohorts, and for the 1970-1979 birth cohort, the highest rate of moderate/high-intensity smoking was 9.7% (95% CI, 7.7%-11.7%) in California and 18.3% (95% CI, 16.4%-20.2%) in the remaining United States. There was a marked decline in moderate/high-intensity smoking at older ages in all cohorts, but this was greater in California. By age 35 years, the prevalence of moderate/high-intensity smoking in the 1970-1979 birth cohort was 4.6% (95% CI, 3.0%-6.1%) in California and 13.5% (95% CI, 11.8%-15.1%) in the remaining United States. CONCLUSIONS Between 1965 and 2007, the prevalence of high-intensity smoking decreased greatly in the United States. The greater decline in high-intensity smoking prevalence in California was related to reduced smoking initiation and a probable increase in smoking cessation.

The California Tobacco Control Program’s effect on adult smokers: (1) Smoking cessation

Objectives: To estimate national population trends in long-term smoking cessation by age group and to compare cessation rates in California (CA) with those of two comparison groups of states. Setting: Retrospective smoking history of a population sample from the US: from CA, with a comprehensive tobacco-control programme since 1989 with the goal of denormalising tobacco use; from New York and New Jersey (NY & NJ), with similar high cigarette prices but no comprehensive programme; and from the tobacco-growing states (TGS), with low cigarette prices, no tobacco-control programme and social norms relatively supportive of tobacco use. Participants: Respondents to the Current Population Survey–Tobacco Use Supplements (1992–2002; n = 57 918 non-Hispanic white ever-smokers). Main outcome measures: The proportion of recent ever-smokers attaining long-term abstinence (quit ⩾1 year) and the successful-quit ratio (the proportion of all ever-smokers abstinent ⩾1 year). Results: Nationally, long-term cessation rates increased by 25% from the 1980s to the 1990s, averaging 3.4% per year in the 1990s. Cessation increased for all age groups, and by >40% (p<0.001) among smokers aged 20–34 years. For smokers aged <50 years, higher cigarette prices were associated with higher quitting rates. For smokers aged <35 years, quitting rates in CA were higher than in either comparison group (p<0.05). Half of the ever-smokers had quit smoking by age 44 years in CA, 47 years in NY & NJ, and by age 54 years in TGS. Conclusion: Successful smoking cessation increased by 25% during the1990s in the US. Comprehensive tobacco-control programmes were associated with greater cessation success than were with high cigarette prices alone, although both effects were limited to younger adults.

Incidence and Prevention of Iatrogenic Urethral Injuries

PURPOSE Although improper urethral catheter insertion is a source of preventable injury in male patients, to our knowledge the extent of this problem is not known. We studied the incidence and mechanism of iatrogenic urinary catheter injuries occurring in adult male inpatients at a single institution. We also designed and implemented an intervention to prevent these injuries. MATERIALS AND METHODS This study was performed during a 13-month period. During months 1 through 6 all catheter related injuries in all adult male admissions to a single academic tertiary care center were prospectively tracked. Incidence data were calculated, injury severity was analyzed and the injury mechanism was identified. During month 7 based on injury mechanism data a nursing education program was designed and implemented by urology staff that included basic urological anatomy, urethral catheter insertion techniques and catheter safety. During months 8 through 13 catheter related injuries were again tracked. The incidences before and after intervention were compared. RESULTS During the pre-intervention period iatrogenic urethral catheter injuries occurred in 14 of 4,310 consecutive adult male admissions, representing an incidence of 3.2 injuries per 1,000 patients. Penile and/or perineal pain occurred in all 14 affected patients (100%) and penile bleeding occurred in 12 (86%). One patient required cystoscopy for catheter placement and 1 experienced recurrent urethral strictures requiring multiple dilations. During the post-intervention period a total of 3 injuries occurred in 4,523 consecutive patients, representing a statistically significant decrease in risk by a factor of 4.9 and an incidence rate of 0.7/1,000 adult male admissions (Fishers exact test p = 0.006). Of the 3 post-intervention injuries 2 (67%) occurred in the operating room, an area that was not targeted as part of the intervention. CONCLUSIONS Iatrogenic urethral injuries are a substantial source of preventable morbidity in hospitalized male patients. Implementation of a nursing education program may significantly decrease the incidence of iatrogenic urethral injury and, thereby, improve patient safety.