Karen O. Brandon

The Self-Report Psychopathy Scale and Passive Avoidance Learning: A Validation Study of Race and Gender Effects.

The reliability and validity of the Self-Report Psychopathy Scale (SRPS) was examined in a noninstitutionalized offender sample of mixed gender and race. Adequate alpha coefficients were obtained for the total sample and across gender and race. The SRPS was compared to measures of trait anxiety and passive avoidance errors. SRPS total, primary, and secondary scores were positively and significantly correlated with trait anxiety and passive avoidance (commission) errors, but not omission errors. Employing hierarchical regression models, no anxiety, gender, or ethnic effects were found. Intelligence confounded the relationship between psychopathic traits and passive avoidance errors. Findings provide tentative support of the SRPS as a valid measure of psychopathy.

The effects of alcohol expectancy priming on group bonding.

According to alcohol expectancy theory, drinking-related information is stored in memory and, when cue activated, influences alcohol-related behavior. Priming of alcohol cues and expectancies has been shown to elicit both drinking and nonconsumptive behavior associated with alcohol consumption, such as willingness to meet with a stranger and aggression. These social influence effects have been shown to be moderated by individual differences in alcohol expectancies. In the present study, we tested whether an alcohol prime would facilitate social group bonding even in the absence of consumption, and whether such group bonding would be moderated by individually held social expectancies. One hundred twenty undergraduates (75% female) completed an alcohol expectancy measure prior to participation. Participants were primed with either alcohol or neutral beverage words and completed a collaborative group activity followed by questionnaires measuring perceived group cohesion. Several interactions were found between condition and expectancy reflecting that those in the alcohol prime condition with higher social alcohol expectancies reported greater cohesion on task-related, but not emotion-related, group measures. These findings underscore the complexity of the impact of expectancy and social behavior on drinking: the priming of alcohol expectancies may activate aspects of pro-social behavior, which may influence drinking, which in turn may feedback to positively reinforce social expectancies.

Facilitated Extinction Training to Improve Pharmacotherapy for Smoking Cessation: A Pilot Feasibility Trial

Introduction Varenicline reduces smoking satisfaction during the pre-cessation run-in period, which may contribute to extinction of cravings and smoking behavior. Research indicates that efficacy is enhanced when the run-in period is increased from 1 to 4 weeks, providing a longer extinction opportunity. We hypothesized that efficacy could be further enhanced by harnessing basic and applied research on extinction. We developed a pre-cessation extinction-facilitating intervention and tested its feasibility in a pilot trial. Methods The facilitated extinction (FE) intervention comprised brief counseling and workbook-recommending strategies to maximize extinction processes during the run-in, including instructions to smoke at a normal rate across contexts and cues, and use of an extinction cue to enhance generalization. Participants were randomly assigned to one of three varenicline interventions: standard (1-week run-in), extended (4-week run-in), and extended + FE. Interventions were delivered prior to the target quit date (TQD). Assessments were conducted in weeks 1 and 4 pre-TQD and 1 and 3 months post-TQD, with focus on feasibility indices. Results Recruitment and retention goals were met (N = 58). Treatment satisfaction was high across groups. The majority of FE participants adhered to instructions and maintained their usual smoking rate during the run-in period. Greater decreases in craving and smoking satisfaction were observed among participants in both extended groups versus the standard group (p < .005). Conclusions Feasibility was demonstrated. Participants adhered to the FE intervention, thereby optimizing the number and variety of extinction trials. Findings support testing the novel FE smoking cessation intervention in a fully powered trial. Implications This study expands the research on the clinical benefits of extending the pre-cessation run-in period of varenicline. It introduces the hypothesis that further benefit might be achieved by translating basic behavioral research, as well as cue-exposure research and therapy for other disorders, to improve the extinction and generalization processes thought to underlie much of vareniclines effect. A FE intervention was developed and found acceptable to smokers and feasible to implement in a research setting. The study sets the stage for a subsequent randomized controlled trial.

Electronic cigarette use among patients with cancer: Reasons for use, beliefs, and patient-provider communication

Smoking tobacco cigarettes after a cancer diagnosis increases risk for several serious adverse outcomes. Thus, patients can significantly benefit from quitting smoking. Electronic cigarettes are an increasingly popular cessation method. Providers routinely ask about combustible cigarette use, yet little is known about use and communication surrounding e‐cigarettes among patients with cancer. This study aims to describe patterns, beliefs, and communication with oncology providers about e‐cigarette use of patients with cancer.

Systematic Transcreation of Self-Help Smoking Cessation Materials for Hispanic/Latino Smokers: Improving Cultural Relevance and Acceptability

Smoking-related illnesses are the leading causes of death among Hispanics/Latinos. Yet, there are few smoking cessation interventions targeted for this population. The goal of this study was to “transcreate” an existing, previously validated, English language self-help smoking cessation intervention, titled Forever Free®: Stop Smoking for Good, for Spanish-speaking smokers. Rather than simply translating the materials, our transcreation process involved culturally adapting the intervention to enhance acceptability and receptivity of the information. We utilized a multiphase qualitative approach (focus groups and learner verification interviews) to develop a linguistically and culturally relevant intervention for the diverse sub-ethnic groups of Hispanic/Latino smokers. Focus group findings indicated a need to underscore several additional cultural characteristics and themes such as the need to address familism and unique stressors faced by immigrants and to provide information regarding nicotine replacement therapy. Learner verification findings indicated a need to further emphasize financial and social benefits of quitting smoking and to discuss how family and friends can support the quit attempt. These steps led to the development of a Spanish-language smoking cessation intervention titled, Libre del cigarillo, por mi familia y por mí: Guía para dejar de fumar, that is currently being tested in a national randomized controlled trial.

Reducing racial/ethnic tobacco cessation disparities via cognitive behavioral therapy: Design of a dualsite randomized controlled trial

Racial/ethnic disparities in tobacco cessation are such that U.S. minorities have greater difficulty quitting compared to White non-Hispanics. Group differences in distress (i.e., perceived stress and depressive symptoms) may contribute to cessation disparities. The allostasis model of health suggests that the toll of chronic stress experienced by racial/ethnic minorities may lead to dysregulation of the physiological stress system and drug use. Previous research suggests that group cognitive behavioral therapy (CBT) for tobacco cessation addresses distress as a modifiable mechanism and has the potential to reduce/eliminate disparities. The present study is a dualsite randomized controlled trial aimed at evaluating the efficacy of group CBT in eliminating racial/ethnic differences in smoking cessation and distress. The study utilizes a [2 (intervention: group CBT or group general health education [GHE]) × 3 (race/ethnicity: African American/Black, Hispanic, White)] factorial design by randomizing 225 adult smokers from the community. Both interventions provide eight counseling sessions and eight weeks of nicotine patch therapy. Assessments occur at the end-of-therapy, and at 3-, 6-, and 12-months. Generalized longitudinal mixed modeling will be used to test our primary abstinence outcome, biochemically-confirmed 7-day point prevalence abstinence at 12-months. We hypothesize that group CBT will reduce or eliminate racial/ethnic differences in perceived stress, depressive symptoms, and smoking cessation compared to group GHE. We also hypothesize that reductions in physiological distress, assessed by salivary cortisol, will mediate racial/ethnic group differences in smoking cessation, particularly among racial/ethnic minorities. This study has implications for eliminating disparities in psychosocial factors related to tobacco use and cessation. TRIAL REGISTRATION Clinicaltrials.govNCT02511236. Registered on July 27, 2015.

Abstract A09: Transcreating self-help smoking cessation intervention materials for Hispanic/Latino smokers: Focus group and learner verification findings

There is a dearth of evidence-based smoking-cessation interventions for Hispanic/Latino smokers, especially for individuals with limited or no English proficiency. Hispanics/Latinos make up 17% of the national population, and in some Hispanic sub-ethnic groups, such as Puerto Ricans and Cubans, smoking prevalence rates are over 30% (greatly exceeding rates of non-Hispanic Whites at 18.1%). Thus, we sought to transcreate our existing validated English-language “Stop Smoking for Good” self-help smoking cessation intervention for Spanish-speaking smokers. The transcreation process involves a series of steps involving translating the text into another language, as well as infusing culturally relevant context, photos, and themes. To begin, focus groups were conducted to assess reactions to the existing English-language materials (10 booklets and 9 pamphlets), and to gather suggestions to adapt content for the intended audience. Specifically, we aimed to identify culturally relevant smoking cessation barriers as well as elements that would increase acceptability in this population. Focus group participants (N=23) were bilingual Hispanic/Latino smokers representing diverse sub-ethnic groups. A key theme that emerged was familism, defined by the sense of attachment, loyalty and collective well-being among the nuclear as well as extended family. This finding prompted us to develop an additional booklet aimed at providing family and friends with the tools necessary to support their loved one9s quit attempt. Other findings included: religion and spirituality as a coping mechanism; the role of coffee as a trigger for smoking; and difficulties for immigrants that serve as stressors for smoking, such as language barriers, being separated from one9s family, and financial problems. Format change suggestions were also reported by participants and included a desire for color images, preference for a bright color palette, and interactive activities. Focus group findings then informed the development of a Spanish-language version of the booklets entitled, “Libre del cigarrillo, por mi familia y por mi.” Subsequently, learner verification interviews (N=10) were conducted with Spanish-speaking Hispanic/Latino smokers who preferred their health education materials in Spanish to assess the appeal and acceptability of the revised content and visual modifications. Overall, participants responded favorably to the revised content. The learner verification process also revealed a need to: expand the explanation of quitting aids, include additional culturally salient daily stressors, and further emphasize the financial benefits of quitting smoking. We will present additional qualitative results from the focus groups and learner verification interviews as well as the finalized Spanish-language version of the booklets. The final version of the Spanish-language materials will be tested in a randomized controlled trial. Citation Format: Diana B. Diaz, Luis M. Monsalve, Thomas H. Brandon, Barbara Pineiro, Lauren R. Meltzer, Cathy D. Meade, Karen O. Brandon, Marina Unrod, Vani N. Simmons. Transcreating self-help smoking cessation intervention materials for Hispanic/Latino smokers: Focus group and learner verification findings. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr A09.