Kari Dunning

Cancer Risk Among Firefighters: A Review and Meta-analysis of 32 Studies

Objective: The objective of this study was to review 32 studies on firefighters and to quantitatively and qualitatively determine the cancer risk using a meta-analysis. Methods: A comprehensive search of computerized databases and bibliographies from identified articles was performed. Three criteria used to assess the probable, possible, or unlikely risk for 21 cancers included pattern of meta-relative risks, study type, and heterogeneity testing. Results: The findings indicated that firefighters had a probable cancer risk for multiple myeloma with a summary risk estimate (SRE) of 1.53 and 95% confidence interval (CI) of 1.21–1.94, non-Hodgkin lymphoma (SRE = 1.51, 95% CI = 1.31–1.73), and prostate (SRE = 1.28; 95% CI = 1.15–1.43). Testicular cancer was upgraded to probable because it had the highest summary risk estimate (SRE = 2.02; 95% CI = 1.30–3.13). Eight additional cancers were listed as having a “possible” association with firefighting. Conclusions: Our results confirm previous findings of an elevated metarelative risk for multiple myeloma among firefighters. In addition, a probable association with non-Hodgkin lymphoma, prostate, and testicular cancer was demonstrated.

Foot Drop Stimulation Versus Ankle Foot Orthosis After Stroke 30-Week Outcomes

Background and Purpose— Drop foot after stroke may be addressed using an ankle foot orthosis (AFO) or a foot drop stimulator (FDS). The Functional Ambulation: Standard Treatment versus Electric Stimulation Therapy (FASTEST) trial was a multicenter, randomized, single-blinded trial comparing FDS and AFO for drop foot among people ≥3 months after stroke with gait speed ⩽0.8 m/s. Methods— Participants (n=197; 79 females and 118 males; 61.14±11.61 years of age; time after stroke 4.55±4.72 years) were randomized to 30 weeks of either FDS or a standard AFO. Eight dose-matched physical therapy sessions were provided to both groups during the first 6 weeks of the trial. Results— There was significant improvement within both groups from baseline to 30 weeks in comfortable gait speed (95% confidence interval for mean change, 0.11–0.17 m/s for FDS and 0.12–0.18 m/s for AFO) and fast gait speed. However, no significant differences in gait speed were found in the between-group comparisons. Secondary outcomes (standard measures of body structure and function, activity, and participation) improved significantly in both groups, whereas user satisfaction was significantly higher in the FDS group than in the control group. Conclusions— Using either an FDS or an AFO for 30 weeks yielded clinically and statistically significant improvements in gait speed and other functional outcomes. User satisfaction was higher in the FDS group. Although both groups did receive intervention, this large clinical trial provides evidence that FDS or AFO with initial physical therapy sessions can provide a significant and clinically meaningful benefit even years after stroke. Clinical Trial Registration Information— URL: http://www.clinicaltrials.gov. Unique Identifier: NCT01138995.

An epidemiological appraisal instrument – a tool for evaluation of epidemiological studies

In recent years, ergonomics practices have increasingly relied upon the knowledge derived from epidemiological studies. In this regard, there is limited research devoted to the exclusive evaluation of the methodological qualities of ergonomics epidemiological studies. The aim of this study was to develop and test a general purpose ‘epidemiological appraisal instrument’ (EAI) for evaluating the methodological quality of existing or new ergonomic epidemiological studies using a critical appraisal system rooted in epidemiological principles. A pilot EAI version was developed and tested by a team of epidemiologists/physicians/biostatisticians, with the team leader being both epidemiologist and ergonomist. The pilot version was further tested with regard to other raters with/without a background in epidemiology, biostatistics and ergonomics. A revised version was evaluated for criterion validity and reliability. An assessor with a basic background in epidemiology and biostatistics would be able to correctly respond on four out of five questions, provided that subject matter expertise is obtained on specific items. This may improve with the articles quality. Training may have an effect upon assessors with virtually no background in epidemiology/biostatistics, but with a background in ergonomics. In this latter case, the inter-rater degree of agreement is largely above 90% and assessors can resolve their differences in a subsequent round. The EAI proved to be a valid and reliable appraisal instrument that may be used in various applications, such as systematic reviews and meta-analyses.

Longer versus shorter mental practice sessions for affected upper extremity movement after stroke: a randomized controlled trial

Objective: To evaluate and compare efficacy of 20-, 40-, and 60-minute mental practice sessions on affected upper extremity impairment and functional limitation. Design: Randomized controlled study with multiple baseline design. Subjects: Twenty-nine subjects with chronic stroke and exhibiting stable, mild hemiparesis. Interventions: Subjects were given 30-minute rehabilitative sessions 3 days/week for 10 weeks, emphasizing affected upper extremity use during valued activities. Directly after these sessions, randomly selected subjects were given audiotaped mental practice for 20, 40, or 60 minutes. Subjects assigned to a control group received the same therapy as the mental practice groups, and an audiotaped sham intervention directly after therapy sessions. Main outcome measures: Fugl-Meyer (FM) motor assessment and Action Research Arm Test (ARAT). Results: No pre-existing differences were found between groups on any demographic variable or movement scale. On the FM, mental practice duration significantly predicted pretesting to post change (P = 0.05), with increasing duration related to larger FM score increases (5.4 point score increase for the 60-minute duration group). On the ARAT, a non-significant trend was seen (P = 0.78), favoring the 20-minute dosing condition (4.5 point increase). Importantly, regardless of dosing condition, subjects administered mental practice exhibited markedly larger score changes on both the FM and ARAT than subjects not receiving mental practice. Conclusions: Sixty minutes of mental practice appears to most significantly reduce affected arm impairment. However, no clear change pattern was seen in affected arm functional limitation according to mental practice duration. Results suggest that a stroke rehabilitative regimen augmented by mental practice renders a greater functional impact than therapy only.

Characteristics of job rotation in the Midwest US manufacturing sector

Job rotation has been advocated as a suitable intervention to control work-related musculoskeletal disorders. However, little is known regarding the prevalence of job rotation, methods used to identify jobs for rotation or the benefits or limitations of job rotation. A web-based questionnaire was developed to survey job rotation practices from Midwest US manufacturing companies. Results indicated that 42.7% of the companies contacted used job rotation, where the median time for which they had used job rotation was 5 years. Job rotation was used mainly to reduce exposure to risk factors for work-related injuries and to reduce work related injuries, whereas supervisor decisions and ergonomic analyses were used to select jobs for the rotation scheme. Major limitations to successful implementation of job rotation included rotation of individuals with medical restrictions, decreased product quality and lack of jobs to rotate to. These findings suggest that further study is needed to determine if exposure to risk factors is reduced through current efforts.

Estimating clinically important change in gait speed in people with stroke undergoing outpatient rehabilitation.

Background and Purpose: Gait speed is commonly used to assess walking ability in people with stroke. It is not clear how much change in gait speed reflects an important change in walking ability. The purpose of this study was to estimate clinically important changes in gait speed by using 2 different anchors for what is considered “important”: stroke survivors and physical therapists perceptions of change in walking ability. Methods: Participants underwent outpatient physical therapy (mean 56 days post-stroke) after a first-time stroke. Self-selected gait speed was measured at admission and discharge. At discharge, participants and their physical therapists rated their perceived change in walking ability on a 15-point ordinal Global Rating of Change (GROC) scale. Estimated important change values for gait speed were calculated by using receiver operating characteristics curves, with the participants and physical therapists GROC as the anchors. Results: The mean (SD) initial gait speed of all participants was 0.56 (0.22) m/s. The estimated important change in gait speed ranged from 0.175 m/s (participants perceived change in walking ability) to 0.190 m/s (physical therapists perceived change in walking ability), depending on the anchor. Discussion and Conclusions: During the subacute stage of recovery, individuals poststroke who experience improvements in gait speed of 0.175 m/s or greater are likely to exhibit a meaningful improvement in walking ability. The estimated clinically important change value of 0.175 m/s can be used by clinicians to set goals and interpret change in individual patients and by researchers to compare important change between groups.

Incontinence-associated dermatitis in a long-term acute care facility.

PURPOSE: The objectives of this study were to (1) measure the prevalence of incontinence-associated dermatitis (IAD) and pressure ulcers (PUs) on admission to a long-term acute care (LTAC) facility; (2) identify factors associated with IAD and PU on admission to an LTAC facility; and (3) measure the incidence of incontinence and PUs in LTAC patients. DESIGN: This was a longitudinal, repeated-measures study; data were collected over a 12-week period. SUBJECTS AND SETTING: One hundred seventy-one patients, with a median age of 55 years. Fifty-four women and 117 men were evaluated. The sample comprises all patients admitted to the 4 LTAC units at the Drake Center in Cincinnati, Ohio. METHODS: Patients were examined using the “Hospital Survey on Incontinence and Perineal Skin Injury” instrument within 24 hours of admission and they were reevaluated weekly using the same tool until discharge. All data were collected by the Drake Center Advanced Wound Team. Prevalence was defined as the frequency of PUs or IAD identified at admission. Incidence was calculated using the formula: the number of new IAD cases/the number of patients without IAD on admission. Pressure ulcer incidence was measured using 2 formulas: (1) the number of patients with new PUs/the number of all patients who did not have PU on admission and (2) the number of patients with new PUs or a PU in a new location/the number of all patients. RESULTS: Thirty-nine out of 171 patients had IAD on admission, yielding a prevalence of 22.8%. Sixty of 171 patients had a PU on admission, yielding a prevalence of 35.1%. Ten of 132 patients who did not have IAD at admission developed IAD during follow-ups, yielding a 7.6% incidence. Two PU incidence rates were measured; those patients without PUs on admission 3.6% (4/111) and all patients 8.2% (14/171). CONCLUSION: The LTAC admission PU prevalence rate in this study was greater than that reported previously in acute or long-term care settings. The LTAC PU incidence rate was less than those reported for both acute and long-term care settings. The LTAC IAD admission prevalence rate closely reflected the acute care rate but was substantially higher than the long-term care rate.

Longer versus shorter daily durations of electrical stimulation during task-specific practice in moderately impaired stroke.

OBJECTIVE To examine and compare efficacy of 30-, 60-, and 120-minute repetitive task-specific practice (RTP) sessions incorporating use of an electrical stimulation neuroprosthesis (ESN) on affected upper-extremity (UE) movement. DESIGN Prospective, single-blinded, randomized controlled trial. SETTING Outpatient rehabilitation hospital. PARTICIPANTS Chronic stroke subjects (N=32) exhibiting moderate, stable affected UE motor deficits. INTERVENTIONS Subjects participated in 30-, 60-, or 120-minute therapy sessions involving RTP incorporating the ESN, occurring every weekday for 8 weeks. During sessions, they wore the ESNs to enable performance of valued activities that they had identified. A fourth group participated in a 30-minute per weekday home exercise program. MAIN OUTCOME MEASURES Outcomes were evaluated using the UE section of the Fugl-Meyer Assessment of Sensorimotor Impairment (FM), the Arm Motor Ability Test (AMAT), the Action Research Arm Test (ARAT), and Box and Block (B&B) 1 week before and 1 week after intervention. RESULTS After intervention, subjects in the 120-minute condition were the only ones to exhibit significant score increases on the FM (P=.0007), AMAT functional ability scale (P=.002), AMAT quality of movement scale (P=.0002), and ARAT (P=.02). They also exhibited the largest changes in time to perform AMAT tasks and in B&B score, but these changes were nonsignificant, (P=.15 and P=.10, respectively). CONCLUSIONS One hundred and twenty minutes a day of RTP augmented by ESN use elicits the largest and most consistent UE motor changes in moderately impaired stroke subjects.

Response and Prediction of Improvement in Gait Speed From Functional Electrical Stimulation in Persons With Poststroke Drop Foot

To describe changes in and predictors of comfortable gait speed (GS‐C) after using a foot‐drop stimulator (FDS; Bioness L300; Bioness Inc, Valencia, CA) for 42 weeks in persons who had sustained a stroke.

HRCT/CT and associated spirometric effects of low Libby amphibole asbestos exposure.

Objective: Evaluate the relationship between cumulative fiber exposure and high-resolution or conventional chest computed tomography (HRCT/CT) changes and spirometry of workers with Libby amphibole asbestos exposure. Methods: Of the original 1980 cohort (n = 513), 431 were living and asked to participate. Images were evaluated for localized pleural thickening (LPT), diffuse pleural thickening (DPT), and parenchymal changes. Results: A total of 306 participants provided either HRCT/CT scans (n = 191) or chest radiographs (n = 115). Of the 191 with HRCT/CT, 52.9% had pleural changes and 13.1% had parenchymal changes. Those with LPT only, LPT and/or DPT, or DPT and/or parenchymal changes had mean 6.1, 8.0, and 18.0 loss in percent predicted forced vital capacity, respectively. Conclusions: Exposure to vermiculite containing amphibole fibers is associated with pleural and parenchymal HRCT/CT changes at low cumulative fiber exposure; these changes are associated with spirometric decrements.