Karin M. Butler

Age differences in veridical and false recall are not inevitable: The role of frontal lobe function

The relationship of neuropsychological measures of frontal lobe function to age differences in false recall was assessed using the Deese/Roediger-McDermott associative false memory paradigm (Deese, 1959; Roediger & McDermott, 1995). As other studies have found, older adults were less likely to correctly recall studied items and more likely to falsely recall highly related but nonpresented items than were younger adults. When older adults were divided based on a composite measure of frontal lobe functioning, this age difference was found only for low frontal lobe functioning individuals. High frontal lobe functioning older adults and young adults had equivalent levels of false recall, as well as equivalent levels of veridical recall. These results suggest that age differences in memory may be due to declines in frontal lobe function. More important, our findings indicate that declines in veridical recall and increases in false recall are not an inevitable consequence of aging.

Implementation intentions facilitate prospective memory under high attention demands

An implementation intention is a planning technique that involves specifying a situation for initiating an intended action and linking these specific cues to the intention. In two experiments with young adults, we found significant increases in prospective memory with implementation intentions. With an implementation intention, but not with standard instructions, prospective memory performance was maintained under demanding attentional conditions (Experiment 2). Ongoing task performance did not decline, however, in relation with a no prospective memory control. Positive effects were not observed when the imagery component of the implementation intention was isolated from the verbal component. We suggest that implementation intention planning (relative to standard instructions) increases the likelihood that people will encode a robust associative link between the target cue and the intended action, thereby promoting reflexive triggering of the intended action on presentation of the target cue.

Expanding Access to BRCA1/2 Genetic Counseling with Telephone Delivery: A Cluster Randomized Trial

BACKGROUND The growing demand for cancer genetic services underscores the need to consider approaches that enhance access and efficiency of genetic counseling. Telephone delivery of cancer genetic services may improve access to these services for individuals experiencing geographic (rural areas) and structural (travel time, transportation, childcare) barriers to access. METHODS This cluster-randomized clinical trial used population-based sampling of women at risk for BRCA1/2 mutations to compare telephone and in-person counseling for: 1) equivalency of testing uptake and 2) noninferiority of changes in psychosocial measures. Women 25 to 74 years of age with personal or family histories of breast or ovarian cancer and who were able to travel to one of 14 outreach clinics were invited to participate. Randomization was by family. Assessments were conducted at baseline one week after pretest and post-test counseling and at six months. Of the 988 women randomly assigned, 901 completed a follow-up assessment. Cluster bootstrap methods were used to estimate the 95% confidence interval (CI) for the difference between test uptake proportions, using a 10% equivalency margin. Differences in psychosocial outcomes for determining noninferiority were estimated using linear models together with one-sided 97.5% bootstrap CIs. RESULTS Uptake of BRCA1/2 testing was lower following telephone (21.8%) than in-person counseling (31.8%, difference = 10.2%, 95% CI = 3.9% to 16.3%; after imputation of missing data: difference = 9.2%, 95% CI = -0.1% to 24.6%). Telephone counseling fulfilled the criteria for noninferiority to in-person counseling for all measures. CONCLUSIONS BRCA1/2 telephone counseling, although leading to lower testing uptake, appears to be safe and as effective as in-person counseling with regard to minimizing adverse psychological reactions, promoting informed decision making, and delivering patient-centered communication for both rural and urban women.

Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up

PURPOSE The ongoing integration of cancer genomic testing into routine clinical care has led to increased demand for cancer genetic services. To meet this demand, there is an urgent need to enhance the accessibility and reach of such services, while ensuring comparable care delivery outcomes. This randomized trial compared 1-year outcomes for telephone genetic counseling with in-person counseling among women at risk of hereditary breast and/or ovarian cancer living in geographically diverse areas. PATIENTS AND METHODS Using population-based sampling, women at increased risk of hereditary breast and/or ovarian cancer were randomly assigned to in-person (n = 495) or telephone genetic counseling (n = 493). One-sided 97.5% CIs were used to estimate the noninferiority effects of telephone counseling on 1-year psychosocial, decision-making, and quality-of-life outcomes. Differences in test-uptake proportions for determining equivalency of a 10% prespecified margin were evaluated by 95% CIs. RESULTS At the 1-year follow-up, telephone counseling was noninferior to in-person counseling for all psychosocial and informed decision-making outcomes: anxiety (difference [d], 0.08; upper bound 97.5% CI, 0.45), cancer-specific distress (d, 0.66; upper bound 97.5% CI, 2.28), perceived personal control (d, -0.01; lower bound 97.5% CI, -0.06), and decisional conflict (d, -0.12; upper bound 97.5% CI, 2.03). Test uptake was lower for telephone counseling (27.9%) than in-person counseling (37.3%), with the difference of 9.4% (95% CI, 2.2% to 16.8%). Uptake was appreciably higher for rural compared with urban dwellers in both counseling arms. CONCLUSION Although telephone counseling led to lower testing uptake, our findings suggest that telephone counseling can be effectively used to increase reach and access without long-term adverse psychosocial consequences. Further work is needed to determine long-term adherence to risk management guidelines and effective strategies to boost utilization of primary and secondary preventive strategies.

Working memory capacity modulates task performance but has little influence on task choice

Variation in the ability to maintain internal goals while resolving competition from multiple information streams has been related to individual differences in working memory capacity (WMC). In a multitask environment, task choice and task performance are influenced by internal goals, prior behavior within the environment, and the availability of relevant and irrelevant information in the environment. Using the voluntary task-switching procedure, task performance, as measured by switch costs, was related to WMC, but only at short preparation intervals. Task choice processes were only weakly related to WMC. These findings are consistent with models of cognitive control that separate task choice processes from the processes of activating and maintaining task readiness. WMC is related to regulation of specific task parameters but not to choice processes integral to the coordination of multiple sources of information.

The Influence of Distinctive Processing Manipulations on Older Adults' False Memory

ABSTRACT Covertly generating item-specific characteristics for each studied word from DRM (Deese–Roediger–McDermott) lists decreases false memory in young adults. The typical interpretation of this finding is that item-specific characteristics act as additional unique source information bound to each studied item at encoding, and at retrieval young adults can use the absence of this type of information to reject non-presented associated words that might otherwise be falsely remembered. In two experiments, we examined whether healthy older adults could use this strategy to reduce their false memories in the DRM paradigm. In Experiment 1, low frontal lobe functioning was associated with increased false memory in the item-specific strategy condition. Experiment 2 found more memory intrusions under item-specific encoding and the same amount of false memory in auditory and visual presentation conditions, i.e., no modality effect, even with 8 s of encoding time. Both findings are consistent with impaired distinctive processing by older adults.

Age-Related Deficits in Reality Monitoring of Action Memories

The authors describe 3 theoretical accounts of age-related increases in falsely remembering that imagined actions were performed (A. K. Thomas & J. B. Bulevich, 2006). To investigate these accounts and further explore age-related changes in reality monitoring of action memories, the authors used a new paradigm in which actions were (a) imagined only, (b) actually performed, or (c) both imagined and performed. Older adults were more likely than younger adults to misremember the source of imagined-only actions, with older adults more often specifying that the action was imagined and also that it was performed. For both age groups, illusions that the actions were only performed decreased as repetitions of the imagined-only events increased. These patterns suggest that both older and younger adults use qualitative characteristics when making reality-monitoring judgments and that repeated imagination produces richer records of both sensory details and cognitive operations. However, sensory information derived from imagination appears to be more similar to that derived from performance for older adults than for younger adults.

The role of verbal short-term memory in task selection: How articulatory suppression influences task choice in voluntary task switching

The roles of verbal short-term memory (vSTM) in task selection and task performance processes were examined when individuals were asked to voluntarily choose which of two tasks to perform on each trial randomly. Consistent with previous voluntary task-switching (VTS) research, we hypothesized that vSTM would support random task selection by maintaining a sequence of previously executed tasks that would be used by a representativeness heuristic. Furthermore, because using a representativeness heuristic requires sufficient time for updating and comparison processes, we expected that vSTM would have a greater effect on task selection when more time was available. Participants completed VTS under concurrent articulatory suppression and foot tapping at short and long response-to-stimulus intervals (RSIs). Task selection in VTS was more repetitive under suppression than under foot tapping, but this effect did not vary with RSI, suggesting that vSTM does not maintain the sequence of executed tasks to guide task selection. Instead, vSTM is critical for maintaining the intended task and ensuring that it is carried out. In contrast to the finding that a working memory load impairs task performance, we found no difference in reaction times and no switch costs between suppression and foot-tapping conditions, suggesting that vSTM is not critical for task performance.

Variation in individuals' semantic networks for common knowledge is associated with false memory

Three experiments assessed the relationships between false memories of words and their degree of connectedness within individual semantic networks. In the first two experiments, participants studied associated word lists (e.g., hot, winter, ice), completed a recognition test that included related nonstudied words (e.g., cold, snow), and then rated the semantic relatedness of all word pairs including studied and nonstudied words. In the third experiment, the task order was reversed; participants completed pairwise ratings and then, two weeks later, completed the false memory task. The relatedness ratings were analysed using the Pathfinder scaling algorithm. In all experiments, items that an individual falsely recognized had higher semantic Pathfinder node densities than those items correctly rejected.

The effects of study order and backward associative strength on illusory recollection: A source-strength effect does not always occur

We investigated illusory recollection by dividing lists of associated words into three subsets (high, medium and low) based on their backward associative strength (BAS) to an unstudied theme. Participants studied these subsets at different visual locations on a computer screen and afterwards were given a source memory test. In Experiment 1, we varied the order in which high- and medium-BAS subsets were studied. In Experiment 2, we again manipulated study order as well as the associative strength of the medium-BAS subsets (strong or weak). Across both experiments, illusory recollection was constrained by both study order and BAS. Source attributions to the high-BAS location were more likely (a source-strength effect) when high-BAS items were studied first or studied following items of relatively low associative strength. However, attributions to the strong medium-BAS studied location were more likely when these items were studied before high-BAS items. These findings are interpreted as resulting from misbinding of source details at encoding which can be explained by the activation-monitoring theory of illusory recollection.