Karl H. Buchel

Industrial inorganic chemistry

Primary inorganic materials: water hydrogen hydrogen peroxide and inorganic peroxo compounds nitrogen and nitrogen compounds phosphorus and its compounds sulfur and sulfur compounds halogens and halogen compounds mineral fertilizers - phosphorus-containing fertilizers nitrogen-containing fertilizers potassium-containing fertilizers. Metals and their compounds: alkali and alkaline earth metals and their compounds aluminum and its compounds chromium compounds and chromium silicon and its inorganic compounds manganese compounds and manganese. Silicones: structure and properties economic importance silicone manufacture industrial silicon products. Inorganic solids: silicate products inorganic fibers construction materials enamels ceramics metallic hard materials carbon modifications fillers inorganic pigments. Nuclear fuel cycle: economic importance of nuclear energy availability of uranium and thorium nuclear reactor types nuclear fuel production disposal of waste from nuclear power stations.

Test Methods for Antifungal Agents—a Critical Review/ Wirksamkeitsuntersuchungen an antimykotischen Substanzen

Summary: The research for new antimycotic agents is markedly hampered by a lack of alternative fungus‐specific test methods in vitro and a limited number of reproducible infection models in vivo.

Antimycotic sterol biosynthesis inhibitors

Abstract The last decade or so has seen the development and increased use of the antifungal azoles. D. Berg and colleagues describe the pharmacology and medicinal chemistry of these compounds which has allowed research in this field to move towards the development of analogues with reduced toxicity suitable for oral and parenteral administration.

Action Mechanisms of Cell-Division-Arresting Benzimidazoles and of Sterol Biosynthesis-Inhibiting Imidazoles, 1, 2, 4-Triazoles, and Pyrimidines

Summary: In spite of a formal similarity between benzimidazoles and azoles, two completely different action mechanisms are in operation, namely inhibition of tubuline association by the benzimidazoles, and inhibition of ergosterol biosynthesis at the stage of C14 demethylation by imidazoles, 1, 2, 4‐triazoles, and pyrimidines.

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF PHENOXY-TRIAZOLYL-METHANES AS INHIBITORS OF STEROL BIOSYNTHESIS

Abstract Triadimefon is a known potent inhibitor of ergosterol biosynthesis in yeasts and fungi and belongs to the Phenoxy-triazolyl-methane group We report on quantitative structure-activity relationship studies according to Hansch in the phenoxy-triazolyl-methane series based on MIC-values against Saccharomycopsis lipolytica in the agar diffusion test and, in comparison, based on 50% inhibition-values for ergosterol biosynthesis in the same yeast. The correlation deduced show that principally pI50-values of ergosterol biosynthesis inhibition in yeast and fungi are of value as biological data in quantitative structure-activity studies in this azole group.

TRIAZOLYL-O,N-ACETALS, CHEMISTRY, ACTIVITY AND STRUCTURE

Abstract The synthesis, biological activity and structure activity relationships of phenoxy-triazolyl-methanes are reported. The synthesis of these compounds is demonstrated for triadimefon, starting from a-chloropinacolone. The biological activity of phenoxy-triazolyl-methanes, the so-called triazolyl-0,N-acetals covers mainly protective, curative, eradicative, and systemic control of powdery mildews, scab and rust. On a series of triazolyl-0,N-acetals rnonosubstituted in the phenyl ring, Spearman rank correlation is investigated. In accordance with this rank correlation, the QSAR shows a good intercorrelation of activity of triazolyl-0,N-acetals against Erysiphe cichoracearurn in protective greenhouse tests and the lipophilicity data π, RM and Verloops sterie parameter B4.