Karla C. Pais
Federal University of Rio de Janeiro
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Publication
Featured researches published by Karla C. Pais.
Bioorganic & Medicinal Chemistry | 2009
Marcus V. N. de Souza; Karla C. Pais; Carlos R. Kaiser; Mônica A. Peralta; Marcelle de L. Ferreira; Maria Cristina S. Lourenço
A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 microg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.
CrystEngComm | 2009
Carlos R. Kaiser; Karla C. Pais; Marcus V. N. de Souza; James L. Wardell; Solange M. S. V. Wardell; Edward R. T. Tiekink
Crystal packing patterns for a range of chloroquine derivatives have been investigated. For species where the amine-bound R substituent carries atoms not capable of forming significant hydrogen bonding interactions, i.e. R = methyl (1), n-propyl (2), n-butyl (3), 2-chloroethyl (4), 2-azidoethyl (5), N–H⋯N hydrogen bonding between the amine and pyridine groups predominate leading to supramolecular chains. In species carrying hydroxyl groups, i.e. R = 2-hydroxylethyl (6), 1-butanol (7), and (S)-1-butanol (8), the N–H⋯N interactions are subverted by O–H⋯N and N–H⋯O hydrogen bonding that results in the formation of 2-D arrays, establishing an hierarchy of hydrogen bonding interactions in these systems. Despite the differences in hydrogen bonding, globally, the crystal packing in all structures is similar in that the N–H⋯N mediated supramolecular chains of (1–5) aggregate into layers usually via C–H⋯π, C–Cl⋯π and π⋯π interactions. These layers, as with those formed in (6–8), stack into a 3-D arrangement being consolidated via C–H⋯Cl and π⋯π or C–Cl⋯π interactions.
Bioorganic & Medicinal Chemistry Letters | 2009
André Luis Peixoto Candéa; Marcelle de L. Ferreira; Karla C. Pais; Laura Nogueira de Faria Cardoso; Carlos R. Kaiser; Maria das Graças Henriques; Maria Cristina S. Lourenço; Flávio A.F.M. Bezerra; Marcus V. N. de Souza
A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a-u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity (2.5 microg/mL), which can be compared with that of the first line drugs, ethambutol (3.12 microg/mL) and rifampicin (2.0 microg/mL). These results can be considered an important start point for the rational design of new leads for anti-TB compounds.
Química Nova | 2009
Ana Paula Bernardo dos Santos; Idila Rafaela Carvalho Gonçalves; Karla C. Pais; Sabrina T. Martinez; Elizabeth R. Lachter; Angelo C. Pinto
Regulatory pressure is increasingly focusing on the use and disposal of substances hazardous to human health and environment. In the last years efforts have also been made to introduce green chemistry concepts in undergraduate courses. In this paper we present an experiment on the oxidation reaction of borneol to camphor with bleach in acetone. This experiment is important to show undergraduate students that a cheap and non hazardous commercial product can be a useful oxidation agent of alcohols.
Journal of Organic Chemistry | 2003
Alessandro B. C. Simas; Karla C. Pais; Angelo A.T. da Silva
Journal of Molecular Catalysis B-enzymatic | 2013
Evelin A. Manoel; Karla C. Pais; Marcella C. Flores; Leandro S. M. Miranda; M. A. Z. Coelho; Alessandro B. C. Simas; Denise Maria Guimarães Freire; Rodrigo O. M. A. de Souza
Organic Process Research & Development | 2012
Evelin A. Manoel; Karla C. Pais; Aline G. Cunha; Alessandro B. C. Simas; M. A. Z. Coelho; Denise Maria Guimarães Freire
Tetrahedron-asymmetry | 2012
Evelin A. Manoel; Karla C. Pais; Aline G. Cunha; M. A. Z. Coelho; Denise Maria Guimarães Freire; Alessandro B. C. Simas
Tetrahedron Letters | 2009
Alessandro B. C. Simas; Daniel L. de Sales; Karla C. Pais
Letters in Drug Design & Discovery | 2006
Ivan N. Junior; Maria Cristina S. Lourenço; Guilherme de B.P. de Miranda; Thatyana R. A. Vasconcelos; Karla C. Pais; Jose dos P. de A. Junior; M. S.V. Wardell; James L. Wardell; V. N. de Souza