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Dive into the research topics where Karla C. Pais is active.

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Featured researches published by Karla C. Pais.


Bioorganic & Medicinal Chemistry | 2009

Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.

Marcus V. N. de Souza; Karla C. Pais; Carlos R. Kaiser; Mônica A. Peralta; Marcelle de L. Ferreira; Maria Cristina S. Lourenço

A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 microg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.


CrystEngComm | 2009

Assessing the persistence of the N–H⋯N hydrogen bonding leading to supramolecular chains in molecules related to the anti-malarial drug, chloroquine

Carlos R. Kaiser; Karla C. Pais; Marcus V. N. de Souza; James L. Wardell; Solange M. S. V. Wardell; Edward R. T. Tiekink

Crystal packing patterns for a range of chloroquine derivatives have been investigated. For species where the amine-bound R substituent carries atoms not capable of forming significant hydrogen bonding interactions, i.e. R = methyl (1), n-propyl (2), n-butyl (3), 2-chloroethyl (4), 2-azidoethyl (5), N–H⋯N hydrogen bonding between the amine and pyridine groups predominate leading to supramolecular chains. In species carrying hydroxyl groups, i.e. R = 2-hydroxylethyl (6), 1-butanol (7), and (S)-1-butanol (8), the N–H⋯N interactions are subverted by O–H⋯N and N–H⋯O hydrogen bonding that results in the formation of 2-D arrays, establishing an hierarchy of hydrogen bonding interactions in these systems. Despite the differences in hydrogen bonding, globally, the crystal packing in all structures is similar in that the N–H⋯N mediated supramolecular chains of (1–5) aggregate into layers usually via C–H⋯π, C–Cl⋯π and π⋯π interactions. These layers, as with those formed in (6–8), stack into a 3-D arrangement being consolidated via C–H⋯Cl and π⋯π or C–Cl⋯π interactions.


Bioorganic & Medicinal Chemistry Letters | 2009

Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives

André Luis Peixoto Candéa; Marcelle de L. Ferreira; Karla C. Pais; Laura Nogueira de Faria Cardoso; Carlos R. Kaiser; Maria das Graças Henriques; Maria Cristina S. Lourenço; Flávio A.F.M. Bezerra; Marcus V. N. de Souza

A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a-u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity (2.5 microg/mL), which can be compared with that of the first line drugs, ethambutol (3.12 microg/mL) and rifampicin (2.0 microg/mL). These results can be considered an important start point for the rational design of new leads for anti-TB compounds.


Química Nova | 2009

Oxidação do borneol à cânfora com água sanitária - um experimento simples, de baixo custo e limpo

Ana Paula Bernardo dos Santos; Idila Rafaela Carvalho Gonçalves; Karla C. Pais; Sabrina T. Martinez; Elizabeth R. Lachter; Angelo C. Pinto

Regulatory pressure is increasingly focusing on the use and disposal of substances hazardous to human health and environment. In the last years efforts have also been made to introduce green chemistry concepts in undergraduate courses. In this paper we present an experiment on the oxidation reaction of borneol to camphor with bleach in acetone. This experiment is important to show undergraduate students that a cheap and non hazardous commercial product can be a useful oxidation agent of alcohols.


Journal of Organic Chemistry | 2003

A more convenient and general procedure for O-monobenzylation of diols via stannylenes: a critical reevaluation of the Bu2SnO method.

Alessandro B. C. Simas; Karla C. Pais; Angelo A.T. da Silva


Journal of Molecular Catalysis B-enzymatic | 2013

Kinetic resolution of a precursor for myo-inositol phosphates under continuous flow conditions

Evelin A. Manoel; Karla C. Pais; Marcella C. Flores; Leandro S. M. Miranda; M. A. Z. Coelho; Alessandro B. C. Simas; Denise Maria Guimarães Freire; Rodrigo O. M. A. de Souza


Organic Process Research & Development | 2012

Kinetic Resolution of 1,3,6-Tri-O-benzyl-myo-Inositol by Novozym 435: Optimization and Enzyme Reuse

Evelin A. Manoel; Karla C. Pais; Aline G. Cunha; Alessandro B. C. Simas; M. A. Z. Coelho; Denise Maria Guimarães Freire


Tetrahedron-asymmetry | 2012

On the kinetic resolution of sterically hindered myo-inositol derivatives in organic media by lipases

Evelin A. Manoel; Karla C. Pais; Aline G. Cunha; M. A. Z. Coelho; Denise Maria Guimarães Freire; Alessandro B. C. Simas


Tetrahedron Letters | 2009

Acyclic ketene aminal phosphates derived from N,N-diprotected acetamides: stability and cross-couplings

Alessandro B. C. Simas; Daniel L. de Sales; Karla C. Pais


Letters in Drug Design & Discovery | 2006

Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives

Ivan N. Junior; Maria Cristina S. Lourenço; Guilherme de B.P. de Miranda; Thatyana R. A. Vasconcelos; Karla C. Pais; Jose dos P. de A. Junior; M. S.V. Wardell; James L. Wardell; V. N. de Souza

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Alessandro B. C. Simas

Federal University of Rio de Janeiro

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Denise Maria Guimarães Freire

Federal University of Rio de Janeiro

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Evelin A. Manoel

Federal University of Rio de Janeiro

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Carlos R. Kaiser

Federal University of Rio de Janeiro

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M. A. Z. Coelho

Federal University of Rio de Janeiro

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Aline G. Cunha

Federal University of Rio de Janeiro

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Ana Paula Bernardo dos Santos

Federal University of Rio de Janeiro

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Angelo C. Pinto

Federal University of Rio de Janeiro

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