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Dive into the research topics where Karoliina Koskenvuo is active.

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Featured researches published by Karoliina Koskenvuo.


European Journal of Epidemiology | 2010

Shift-work and cardiovascular disease: a population-based 22-year follow-up study

Christer Hublin; Markku Partinen; Karoliina Koskenvuo; Karri Silventoinen; Markku Koskenvuo; Jaakko Kaprio

Studies on the association between shift-work and cardiovascular disease (CVD), in particular coronary heart disease (CHD), have given conflicting results. In this prospective population-based study we assessed the association of shift-work with three endpoints: CHD mortality, disability retirement due to CVD, and incident hypertension. A cohort of 20,142 adults (the Finnish Twin Cohort) was followed from 1982 to 2003. Type of working time (daytime/nighttime/shift-work) was assessed by questionnaires in 1975 (response rate 89%) and in 1981 (84%). Causes of death, information on disability retirement and hypertension medication were obtained from nationwide official registers. Cox proportional hazard models were used to obtain hazard ratios (HR) for each endpoint by type of working time. Adjustments were made for 14 socio-demographic and lifestyle covariates. 76.9% were daytime workers and 9.5% shift-workers both in 1975 and in 1981. During the follow-up, 857 deaths due to CHD, 721 disability retirements due to CVD, and 2,642 new cases of medicated hypertension were observed. However, HRs for shift-work were not significant (mortality HR men 1.09 and women 1.22; retirement 1.15 and 0.96; hypertension 1.15 and 0.98, respectively). The results were essentially similar after full adjustments for all covariates. Within twin pairs, no association between shift work and outcome was observed. Our results do not support an association between shift-work and cardiovascular morbidity.


Sleep Medicine | 2010

Childhood adversities and quality of sleep in adulthood: A population-based study of 26,000 Finns

Karoliina Koskenvuo; Christer Hublin; Markku Partinen; Tiina Paunio; Markku Koskenvuo

OBJECTIVE To find out if childhood adversities predict poor sleep quality in working age. METHODS Survey data from the Health and Social Support (HeSSup) study was used (N=25,605, 59% women). Negative childhood adversities and quality of sleep in adulthood were assessed by the questionnaire in 1998. Multinomial regression models were used. RESULTS A graded association between childhood adversities and the quality of sleep in adulthood was found. Odds ratio (OR) of poor quality of sleep for those with multiple childhood adversities (3-6) was 3.64 (95% CI 2.94-4.50). The association between childhood adversities and the quality of sleep remained significant after adjustments for work status, use of psychotropic drugs, health behaviours, recent life events and child-parent relationships. Poor quality of sleep was clearly increased among those with both poor child-mother (OR 10.4, 95% CI 6.73-16.07) or poor child-father (OR 5.4, 95% CI 3.89-7.50) relationships and multiple childhood adversities. In the analyses of specific childhood adversities, frequent fear of a family member and serious conflicts in the family showed the strongest associations. CONCLUSIONS The strong association between childhood adversities and the quality of sleep in adulthood highlights the importance of early life circumstances on adult health. Early stage recognition, prevention and supportive measures against childhood adversities and serious family conflicts should be promoted.


Scandinavian Journal of Public Health | 2011

Health-related risk factors for disability pensions due to musculoskeletal diagnoses: A 30-year Finnish twin cohort study

Annina Ropponen; Karri Silventoinen; Pia Svedberg; Kristina Alexanderson; Karoliina Koskenvuo; Antti Huunan-Seppälä; Markku Koskenvuo; Jaakko Kaprio

Aims: There is a need to better understand work incapacity due to musculoskeletal disorders (MSD) and the factors that contribute to being granted disability pension (DP) with such disorders. A twin cohort study would serve a powerful tool responding to this knowledge gap by providing information on factors affecting DP when controlling for family background. The purpose was to investigate the incidence of and risk factors for DP due to any MSD (n = 1,819) and specifically due to osteoarthritis (OA, n = 677) in a twin cohort of 24,043 people over a 30-year follow-up. Methods: Data on twin pairs from a mailed questionnaire during the baseline year of 1975 were followed up with register data regarding DP, emigration, old-age pension, and death. For statistical analysis, univariate and multivariate Cox proportional hazard ratios were estimated. Results: Baseline musculoskeletal pain, frequency of use of analgesics, body mass index, and chronic diseases, as well as education and social class were significant risk factors for DP due to MSD at follow-up in both sexes. These factors were also the significant predictors of DP due to OA in men. In women, DP due to OA was best predicted by baseline musculoskeletal pain and lower social class. Conclusions: The risk of DP due to MSD and OA seemed to be influenced by comorbidities, educational level and social class. Analyses of twin pairs discordant for DP confirmed the results. Accumulated health problems and chronic conditions during the life course may lead to permanent work incapacity.


BMJ Open | 2012

Non-response in a nationwide follow-up postal survey in Finland: a register-based mortality analysis of respondents and non-respondents of the Health and Social Support (HeSSup) Study

Sakari Suominen; Karoliina Koskenvuo; Lauri Sillanmäki; Jussi Vahtera; Katariina Korkeila; Mika Kivimäki; Kari J. Mattila; Pekka Virtanen; Markku Sumanen; Päivi Rautava; Markku Koskenvuo

Objective To examine difference in mortality between postal survey non-respondents and respondents. Design A prospective cohort study with baseline survey in 1998 and comprehensive linkage to national mortality registers until 2005, the Health and Social Support study. Setting A population-based postal survey of the working-aged population in Finland in 1998. Participants The original random sample comprised 64 797 working-aged individuals in Finland (20–24, 30–34, 40–44, 50–54 years of age; 32 059 women and 32 716 men), yielding 25 898 (40.0%) responses in the baseline postal survey in 1998. Primary outcome measure Registry-based primary causes of death encoded with the International Classification of Diseases (ICD-10). Results In women, HR for total mortality was 1.75 (95% CI 1.40 to 2.19) times higher among the non-respondents compared with the respondents. In men, non-response was associated with a 1.41-fold (1.21–1.65) excess risk of total mortality. Non-response associated in certain age groups with deaths due to diseases in women and with deaths due to external causes in men. The most prominent excess mortality was seen for total mortality for both genders and for mortality due to external causes among men. Conclusions Postal surveys result in slight underestimation of illness prevalence.


Journal of Occupational and Environmental Medicine | 2011

Health-Related and Sociodemographic Risk Factors for Disability Pension due to Low Back Disorders A 30-Year Prospective Finnish Twin Cohort Study

Sanna Pietikäinen; Karri Silventoinen; Pia Svedberg; Kristina Alexanderson; Antti Huunan-Seppälä; Karoliina Koskenvuo; Markku Koskenvuo; Jaakko Kaprio; Annina Ropponen

Objectives: To investigate health-related and sociodemographic risk factors for disability pensions (DP) due to low back disorders (LBD). Methods: Questionnaire data in 1975 of the Finnish Twin Cohort Study with record linkage to information on DP due to LBD from the official pension registers during follow-up 1975 to 2004 was analyzed with Cox proportional hazard models. Results: Musculoskeletal pain (Hazards Ratio [HR] = 2.36 to 2.39; 95% CI 1.97 to 2.88), smoking (HR = 1.82; 1.49 to 2.22), frequent analgesics use (HR = 1.67; 1.38 to 2.02), and presence of other chronic disease (HR = 1.44; 1.22 to 1.70) increased the risk for DP due to LBD. Years of education decreased the risk (HR = 0.81; 0.77 to 0.85). Associations remained significant when adjusted for familial background. Conclusions: Health-related and sociodemographic risk factors for DP due to LBD can be identified early in life, and they seem independent from familial effects.


Scandinavian Journal of Work, Environment & Health | 2013

Disability pension due to musculoskeletal diagnoses: importance of work-related factors in a prospective cohort study of Finnish twins

S Kärkkäinen; Janne Pitkäniemi; Karri Silventoinen; Pia Svedberg; Antti Huunan-Seppälä; Karoliina Koskenvuo; Markku Koskenvuo; Kristina Alexanderson; Jaakko Kaprio; Annina Ropponen

OBJECTIVES The aim of this study was to investigate the impact of work-related risk factors for future disability pension (DP) due to musculoskeletal diagnoses and for a subgroup of these, namely, DP due to osteoarthritis. METHODS For this prospective study of 16,028 Finnish twins born in 1911-1957 and employed at baseline, a postal questionnaire collected information in 1975 on work-related factors; follow-up data on DP was gathered through register linkages up to 2004. A series of proportional hazards (Cox) regression models were used to analyze the associations between work-related factors and the incidence of DP. RESULTS During the 30-year follow-up, 1297 participants (8%) were granted DP due to musculoskeletal diagnoses, 376 of which were due to osteoarthritis. High stress of daily activities, monotonous work, physical workload (namely work including lifting and carrying or physically heavy work), several workplace changes, and unemployment displayed a strong association with DP due to musculoskeletal diagnoses that was not affected by familial factors, including genetics and shared environment. Additionally, standing work increased the risk for DP due to osteoarthritis. CONCLUSIONS Uninfluenced by family background or other confounding factors, several work-related factors were identified as being strong and direct risk factors for DP due to musculoskeletal diagnoses.


Journal of Occupational and Environmental Medicine | 2012

Effects of work and lifestyle on risk for future disability pension due to low back diagnoses: a 30-year prospective study of Finnish twins.

Annina Ropponen; Karri Silventoinen; Pia Svedberg; Kristina Alexanderson; Antti Huunan-Seppälä; Karoliina Koskenvuo; Markku Koskenvuo; Jaakko Kaprio

Objective: To investigate work and lifestyle factors as predictors for disability pension (DP) due to low back diagnoses (LBDs) during a 30-year follow-up. Methods: Baseline survey data were obtained in 1975 for 16,028 working-age twins followed with register data on DP, emigration, old-age pension, and death until end of 2004; analyzed by Cox proportional hazards regression. Results: Among those at work at baseline, 470 DPs due to LBDs were granted during the follow-up. Monotonous work, lifting and carrying at work or physically heavy work, and unemployment at least once before baseline were significant predictors for DP. A healthy lifestyle was a protective factor for DP. Family background played a role in all these associations. Conclusion: The factors shared by family members seemed to influence both work and lifestyle factors, which then influenced the incidence of DP due to LBDs.


European Journal of Pain | 2011

The burden of symptoms predicts early retirement: A twin cohort study on fibromyalgia-associated symptoms

Ritva Markkula; Eija Kalso; Antti Huunan-Seppälä; Markku Koskenvuo; Karoliina Koskenvuo; Päivi Leino-Arjas; Jaakko Kaprio

Objective: To assess whether symptoms of fibromyalgia (FM) predict disability retirement or mortality.OBJECTIVE To assess whether symptoms of fibromyalgia (FM) predict disability retirement or mortality. METHODS All Finnish Twin Cohort members and diagnosed FM-patients who had answered the same health questionnaire in 1990-1992 were studied. A sample of 10,608 working aged individuals of the cohort was classified in homogenous groups based on symptom profile with latent class analysis, using a battery of questions addressing FM-associated symptoms validated between FM-patients and twins. This resulted in three classes: no or few symptoms (LC1), some symptoms (LC2), and high load of FM-symptoms (LC3). In a 14-year follow-up, 1990-2004, information on disability retirement was obtained from official pension registers. Further linkage with Population Register Centre data for 1990-2009 yielded information on the vital status of the cohort subjects. Those with malignancies or inflammatory rheumatic diseases were excluded. RESULTS Cumulative incidence of early disability retirement was 9.5% among all 8448 individuals (after exclusions), and 26% in LC3. Adjusted hrs for early retirement were 1.0 (reference class) in LC1, 1.5 (95%CI 1.2-1.7) in LC2, and 2.9 (2.4-3.6) in LC3 for all causes and 1.8 (1.4-2.5) in LC2 and 5.0 (3.6-6.9) in LC3 for musculoskeletal disorders. In 173,675 person-years, the high symptom class (LC3) had a 43% (95% CI 17-75%) increased overall mortality risk, which was fully accounted for by adjustment for lifestyle factors, mainly smoking. CONCLUSION Symptoms associated with FM strongly correlate with early disability retirement. Lifestyle problems associated with high symptom load need prompt management to avoid increased risk of mortality.


Journal of Epidemiology and Community Health | 2015

Childhood adversities predict strongly the use of psychotropic drugs in adulthood: a population-based cohort study of 24 284 Finns

Karoliina Koskenvuo; Markku Koskenvuo

Background Exposure to adverse childhood experiences has been shown to be associated with negative health outcomes including mental health problems, but only a few studies with register-based data have used psychotropic drugs as an outcome variable. The purpose of this study is to examine whether adverse emotional childhood experiences, such as serious conflicts in the family and frequent fear of a family member, predict the use of psychotropic drugs in adulthood. In addition, the association of a child–parent relationship during childhood with the use of psychotropic drugs is studied. Methods The participants of the population-based Health and Social Support Study (24 284 working aged Finns) were followed up for 9 years. The information on childhood experiences and child–parent relationships was obtained from the questionnaires in 1998 and 2003. The number of psychotropic purchases (antipsychotics, drugs for bipolar disorder, antidepressants, anxiolytics, hypnotics and sedatives) was obtained from the National-Drug-Prescription-Register. Logistic and multinomial regression models were used. Results A graded association between childhood adversities and the use of psychotropic drugs was found, even after adjustments for occupational training, work status, recent life events and health behaviour. Frequent fear of a family member showed the strongest association: the OR for multiple use of antidepressants was 3.08 (95% CI 2.72 to 3.49) and 2.69 (2.27 to 3.20) for multiple use of anxiolytics. Use of psychotropic drugs was clearly increased among those with poor child–parent relationship and multiple childhood adversities. Conclusions The results highlight the effect of environmental factors during childhood on mental health and the need for early recognition of families at risk.


Nordic studies on alcohol and drugs | 2012

Best friend's and family members' smoking habits and parental divorce during childhood are associated with smoking in adulthood

Ulla Broms; Karoliina Koskenvuo; Lauri Sillanmäki; Kari J. Mattila; Markku Koskenvuo

Aims Smoking initiation during childhood or adolescence is strongly associated with friends’ smoking. Likewise, adverse living conditions increase the likelihood of future deviant behaviour. We examine whether smoking by a best friend and family members during school years as well as adverse childhood experiences are associated with smoking in adulthood. Data and Design We have analysed the responses of Finnish working-aged respondents in 1998 (N=25901) and 2003 (N=20773) to questions on the smoking status of friends and family members during school years as well as their answers on a six-item scale of childhood adversities. A case-control study design was used to compare current cigarette smokers (1998 and 2003) to non-smokers (1998 and 2003). Results If a best friend during school years was a smoker, the subject s odds ratio (OR) of being a smoker in adulthood was 4.43 among females and 3.91 among males compared to those with a non-smoking best friend in multivariate models adjusted for smoking by family members during school years and by six childhood adversities. These associations did not differ by age. Smoking in adulthood was associated with childhood adversities, most strongly with parental divorce or separation during the subjects’ school years. Conclusion Smoking by a best friend and parental divorce or separation during school years appears to be a strong factor of smoking in later life.

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