Karri S. Hawley

Spaced-Retrieval Effects on Name-Face Recognition in Older Adults with Probable Alzheimer's Disease.

Six older adults with probable Alzheimer’s disease (AD) were trained to recall a name-face association using the spaced-retrieval method. We administered six training sessions over a 2-week period. On each trial, participants selected a target photograph and stated the target name, from eight other photographs, at increasingly longer retention intervals. Results yielded a positive effect of spaced-retrieval training for name-face recognition. All participants were able to select the target photograph and state the target’s name for longer periods of time within and across training sessions. A live-person transfer task was administered to determine whether the nameface association, trained by spaced-retrieval, would transfer to a live person. Half of the participants were able to call the live person by the correct name. These data provide initial evidence that spaced-retrieval training can aid older adults with probable AD in recall of a name-face association and in transfer of that association to an actual person.

Knowledge of memory aging and Alzheimer's disease in college students and mental health professionals

In this study, college students and mental health professionals completed the Knowledge of Memory Aging Questionnaire, Alzheimers Disease Knowledge Test and the Fraboni Scale of Ageism before and after a lecture on normal and pathological memory issues in adulthood. Results confirmed that professionals were more knowledgeable about memory aging and Alzheimers disease (AD) and less ageist than college students. Analyses of pre- and post-lecture response accuracy yielded comparable benefits in memory aging and AD knowledge for both groups. Correlation analyses provided modest evidence for the influence of ageist attitudes on the knowledge measures. Implications for memory education programs and psychology curriculum are considered.

Booster Sessions Enhance the Long-Term Effectiveness of Spaced Retrieval in Older Adults with Probable Alzheimer's Disease:

Six older adults with probable Alzheimers disease (AD) were trained to recall a name—face association using the spaced retrieval technique. In this study, we retested these persons in a 6-month follow-up program. For half of the participants, three booster sessions were administered at 6, 12, and 18 weeks after original training to promote long-term retention of the name— face association. Results yielded a mnemonic benefit of the booster sessions at retest. Participants were successful in transferring this association to the actual person in the target photograph. These data confirmed the positive effect of spaced retrieval on recall of a name—face association over a 6-month interval. Implications for memory remediation in cognitively impaired older adults are considered.

Pictorial superiority effects in oldest-old people

We examined memory for pictures and words in middle-age (45–59 years), young-old (60–74 years), old-old (75–89 years), and the oldest-old adults (90–97 years) in the Louisiana Healthy Aging Study. Stimulus items were presented and retention was tested in a blocked order where half of the participants studied 16 simple line drawings and the other half studied matching words during acquisition. Free recall and recognition followed. In the next acquisition/test block a new set of items was used where the stimulus format was changed relative to the first block. Results yielded pictorial superiority effects in both retention measures for all age groups. Follow-up analyses of clustering in free recall revealed that a greater number of categories were accessed (which reflects participants’ retrieval plan) and more items were recalled per category (which reflects participants’ encoding strategy) when pictures served as stimuli compared to words. Cognitive status and working memory span were correlated with picture and word recall. Regression analyses confirmed that these individual difference variables accounted for significant age-related variance in recall. These data strongly suggest that the oldest-old can utilise nonverbal memory codes to support long-term retention as effectively as do younger adults.

A comparison of adjusted spaced retrieval versus a uniform expanded retrieval schedule for learning a name-face association in older adults with probable Alzheimer's disease.

We compared the efficacy of two memory training schedules, adjusted spaced retrieval and uniform expanded retrieval, for learning a name–face association in 12 older adults with probable Alzheimers disease (AD). Nine training sessions were administered on alternate days for three weeks. Results yielded a positive effect of adjusted spaced retrieval on the proportion of correct recall trials and greater success in transferring the learned information to the live target, compared to the uniform expanded retrieval schedule. These data suggest that the spacing effect may underlie the memorial benefit of spaced retrieval. Implications for practical uses of spaced retrieval are considered.

Spaced Retrieval Enhances Memory for a Name–Face–Occupation Association in Older Adults With Probable Alzheimer's Disease

ABSTRACT The authors trained 4 older adults with probable Alzheimers disease to recall a name–face–occupation association using the spaced retrieval technique. Six training sessions were administered over a 2-week period. On each trial, participants selected a target photograph and stated the target name and occupation at increasingly longer retention intervals, contingent upon successful recall. Two transfer tasks were included to determine whether the trained association transferred to the person whose picture served as the training stimulus. Results yielded a positive effect of spaced retrieval on memory for the trained association. Analyses of errors revealed that participants remembered the target persons occupation more often than his or her name. There was modest evidence of transfer of the name–face–occupation association to the actual person. Implications of these data for memory remediation and quality of life in cognitively impaired older adults are considered.

CD8 T-cell immune phenotype of successful aging

The nonagenarian population by definition represents individuals who have demonstrated success in aging. We determined the status of CD8(+) T-cell senescence in nonagenarians by analyzing the expression of CD28 and Fas (CD95), and analyzing activation and activation-induced cell death (AICD). Peripheral blood mononuclear cells (PBMCs) were isolated from three groups of subjects: adults (20-64-year-old), older adults (65-89-year-old), and nonagenarians (>or=90-year-old). PBMCs were stimulated with phytohemagglutinin (PHA) (10 microg/ml). The cells were labeled with conjugated antibodies specific for CD4, CD8, CD28, CD45RO, and Fas, and were analyzed by FACS((R)). There was a strong negative correlation of the percentage of CD28(+)Fas(-) CD8(+) T-cells with the age of each individual prior to stimulation in vitro (R(2)=0.76, p<0.0001). Compared to other biomarkers (CD28(-), CD28(-)CD45RO(+), and Fas(+)) that have been associated with CD8(+) T-cell aging, the loss of the CD28(+)Fas(-) CD8(+) T-cell population exhibited the strongest correlation with the individuals chronologic age. After stimulation with PHA, there was a decrease in the percentage of CD8(+) T-cells from individual >or=65-year-old that expresses both CD28(+) and Fas(+) at day 3. Surprisingly, the AICD response of CD8(+) T-cells at day 7 in the nonagenarians was higher than that in the other two groups. These results suggest that successful aging does not prevent development of the senescent phenotype of unstimulated CD8(+) T cells, but is associated with preservation of CD8 T cell functions including activation and AICD. Increased AICD may result in enhanced rejuvenation capacity of T cells and limit the impact of aging on T cell function in nonagenarians.