Katalin Nogradi
Hungarian Academy of Sciences
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Publication
Featured researches published by Katalin Nogradi.
Tetrahedron | 1983
Lajos Szabo; Janos Sapi; Katalin Nogradi; G. Kalaus; Csaba Szántay
Abstract Starting from l -tryptophan two chiral syntheses of the 3S, 17S-lactam 11, an intermediate for the preparation of (+)-vincamine and its derivatives, were elaborated in good overall yield and with an optical purity of 96%.
Journal of The Chemical Society-perkin Transactions 1 | 1985
Gábor Tóth; Csaba Szántay; Lajos Szabo; Katalin Nogradi; Gyorgy Kalaus
Several 14-hydroxy-E-homoeburnane diastereoisomers have been synthesized and studied by 1H and 13C n.m r spectroscopy. The relative configurations and predominating conformations have been established. It has been shown that previous assignments of C-17 and C-20 signals of trans-D/E-ring-fused Vinca alkaloids must be reversed.
Bioorganic & Medicinal Chemistry Letters | 2016
Olivér Éliás; Katalin Nogradi; György Domány; Zoltán Szakács; János Kóti; Csaba Szántay; Ákos Tarcsay; György M. Keserű; Aniko Gere; Bela Kiss; Dalma Kurkó; Sándor Kolok; Zsolt Némethy; Zoltán Kapui; Éva Hellinger; Monika Vastag; Katalin Saghy; Rita Kedves; István Gyertyán
As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT2C receptor a novel series of 3-amino-1-phenylpropoxy substituted diphenylureas was identified. From that collection two promising compounds (2 and 3) exhibiting highest 5-HT2C receptor affinity strongly inhibited the 5-HT2C receptor agonist 1-(3-chlorophenyl)piperazine (mCPP) induced hypomotility in mice. In further pursuance of that objective (2-aminoethyl)(benzyl)sulfamoyl diphenylureas and diphenylpiperazines have also been elaborated. Herein we report the synthesis of potent multiple-acting compounds from this new class. However, when two optimized representatives (6 and 14) possessing the desired in vitro profile were tested neither reduced the motor activity of mCPP treated animals. Comparative albeit limited in vitro structure-activity relationship (SAR) analysis and detailed in vivo studies are discussed and explanation for their intricate behaviour is proposed.
Archive | 2004
Eva Againe Csongor; János Galambos; Katalin Nogradi; Istvan Vago; István Gyertyán; Bela Kiss; István Laszlovszky; Judit Laszy; Katalin Saghy
Archive | 2002
János Galambos; Katalin Nogradi; Eva Againe Csongor; György M. Keserü; Istvan Vago; György Domány; Bela Kiss; Irstvan Gyertyan; István Laszlovszky; Judit Laszy
Archive | 2002
Katalin Nogradi; János Galambos; Tibor Acs; István Borza; Attila Bielik; György Domány; Bela Kiss; István Gyertyán; István Laszlovszky; Attila Horváth
Archive | 2009
Laszlo Czibula; Bálint Juhász; Eva Againe Csongor; Ferenc Sebok; János Galambos; Katalin Nogradi
Archive | 1978
Csaba Szántay; Lajos Szabo; Katalin Honty; Katalin Nogradi; Karola Jovanovics; Eszter Dezseri; Lajos Dancsi; Csaba Lorincz; Bela Szarvady; Lajos Kovacs
Heterocycles | 2000
Andras Nemes; Janos Kreidl; Laszlo Czibula; Katalin Nogradi; Maria Farkas; Csaba Szántay; Gábor Tárkányi; Gábor Balogh; Ida Deutsch nee Juhasz; Alajos Kálmán; László Párkányi
Archive | 2006
Katalin Nogradi; Gábor Wágner; György M. Keserü; Attila Bielik; Tamás Gáti; Viktor Háda; János Kóti; Krisztina Gál; Monika Vastag; Amrita Bobok