Katarzyna Łuczak

Resistin increases with obesity and atherosclerotic risk factors in patients with myocardial infarction

The objective of the study was to assess the relation of resistin to the anthropometric parameters, metabolic risk factors, and C-reactive protein (CRP) in men with myocardial infarction. Subjects were 40 obese (age, 53.6 +/- 7.39 years; body mass index, > or =30 kg/m2) and 40 lean (age, 54.4 +/- 6.62 years; body mass index, <25 kg/m2) men with first acute myocardial infarction. Waist and hip circumferences, CRP, uric acid, fasting glucose, lipid profile, and blood resistin concentration were measured. In obese patients, triglycerides, fasting glucose, and CRP were significantly higher whereas high-density lipoprotein cholesterol was lower than in lean patients. The range of blood resistin concentration was 6.0 to 70.5 ng/mL: 27.84 +/- 12.15 ng/mL in obese subjects and 17.35 +/- 11.08 ng/mL in lean subjects (P < .0001). Significant positive correlation was revealed between blood resistin concentration and each of the analyzed anthropometric parameter and with fasting glucose, low-density lipoprotein cholesterol, and CRP, whereas negative relation was observed between resistin and high-density lipoprotein cholesterol. As revealed by univariate logistic regression analysis, risk of blood resistin concentration being greater than the median value (19.75 ng/mL) was increased by obesity, high-density lipoprotein cholesterol <40 mg/dL, hypertension, and CRP. In multivariate model, independent variables associated with higher median of resistin were obesity and CRP. Obesity increased 5.5-fold the probability of blood resistin concentration being greater than 19.75 ng/mL, whereas each 1-mg/dL increase in CRP increased this probability by 13%. In patients with acute myocardial infarction, obesity is positively related to blood resistin concentration. Resistin is likely to play a major role in the atherogenesis and its complications, and this action seems to be mostly related to the inflammatory reaction.

Papillary fibroelastoma of the mitral valve as an unusual cause of myocardial infarction in a 20-year-old patient

The incidence of primary cardiac tumours is <0.1% and papillary fibroelastomas are relatively rare when compared with myxomas and lipomas. Papillary fibroelastoma is generally small and single, occurs most often on valvular surfaces, and may be mobile. Despite the embolic potential of primary cardiac tumours, they are extremely uncommon cause of ischaemic vascular accidents. Patients …

Thrombus formation on the Amplatzer device: a need for critical attitude in percutaneous patent ovale closure decision-making

A 37-year-old female was admitted to the hospital for the gradually increasing fatigue 2 months after 9-PFO-025 Amplatzer Occluder implantation. The decision to close patent foramen ovale (PFO) with right-to-left shunt upon Valsalva manoeuvre was made after the clinically diagnosed transient ischaemic attack. According to her medical history, 3 years ago an incident of deep vein thrombosis followed by the diagnosis of the …