Katarzyna Skorupska

Can botox improve night-time overactive bladder symptoms in women?

Despite the efficacy of intravesical onabotulinumtoxinA (Botox) therapy for urgency, urgency incontinence, and daytime frequency, its value in treatment of nocturia remains unclear. The aim of the prospective observational study was to assess the effect of onabotulinumtoxinA on night‐time symptoms in women with overactive bladder (OAB), including nocturia, night‐time urgency incontinence, and nocturnal voided volume as end‐points.

Impact of intravesical onabotulinumtoxinA on sexual function in women with OAB

Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire.

Are there any differences in quality of life and sexual functions after various types of hysterectomy - does prophylactic salpingectomy matter?

Objectives: To assess if general quality of life and sexuality following hysterectomy performed due to benign conditions depends on the surgical approach. The SF 36v2 and FSFI were analyzed postoperatively among women after: supracervical laparoscopic hysterectomy (SLH), total abdominal hysterectomy (TAH), supracervical abdominal hysterectomy (SAH) and vaginal hysterectomy (VH). Material and methods: Study group consisted of 392 women who underwent SLH, TAH, SAH or VH for benign indications between 2010 and 2013. Additionally we analyzed patients: I-with bilateral salpingectomy and IIwithout salpingectomy. Sexuality and general quality of life status were assessed 12 months after operation using two questionnaires: the FSFI and the SF 36v2. Results: Postoperative SF 36v2 scores were significantly higher only in SLH group (p≤0,05). Furthermore postoperative FSFI scores were significantly higher in SLH when compared to SAH, TAH and VH groups (p≤0,05) and also significantly higher in SAH group than in VH group (p≤0,05). Additional prophylactic salpingectomy did not affect the woman’s quality of life and sexuality. Conclusions: Quality of life and sexual functions after SLH are better than after TAH, SAH and VH. Salpingectomy does not exert any significant influence, either on the general quality of life or sexuality in patients after different types of hysterectomy.

Inhibition of Rho kinase by GSK 269962 reverses both corticosterone-induced detrusor overactivity and depression-like behaviour in rats

ABSTRACT Literature data give clear evidence that upregulated RhoA/Rho‐kinase signalling is one of the factors that may lead to the development of detrusor overactivity and various disorders of the central nervous system. Therefore, the main objective of our study was to investigate whether administration of a Rho‐kinase inhibitor – GSK 269962 could reverse corticosterone‐induced depressive‐like behaviour and changes in cystometric parameters associated with detrusor overactivity, as well as undo the alterations of several biomarkers related to both disorders (i.e., pro‐inflammatory/anti‐inflammatory cytokines and neurotrophins) in serum, urinary bladder, and different brain structures. The experiments were carried out on female Wistar rats. Surgical procedures, cystometric investigations, biochemical analyses, and behavioural studies (measurement of the locomotor activity and the forced swim test) were performed according to the published literature. As expected, administration of corticosterone at a daily dose of 20mg/kg for 14 days increased the immobility time of animals in the forced swim test, induced changes in the cystometric parameters specific to bladder overactivity, reduced levels of neurotrophins, and elevated concentrations of the pro‐inflammatory cytokines. Inhibition of Rho‐kinase by 7‐day treatment with GSK 269962 (10mg/kg/day) reversed the symptoms of both detrusor overactivity and depression as well as normalized levels of the tested biomarkes. Our findings encourage the idea of Rho‐kinase inhibitors as a potential future treatment option for overactive bladder accompanied by depression.

Urinary incontinence after hysterectomy- does type of surgery matter?

Objectives The aim of the study was to assess the effect of different types of hysterectomy on the development of postoperative urinary incontinence (UI). Materials and Methods The study group consisted of 392 women who underwent supracervical laparoscopic hysterectomy (SLH), total abdominal hysterectomy (TAH), supervical abdominal hysterectomy (SH), or vaginal hysterectomy (VH) for benign indications 2010 and 2013. The patients reported no UI-related complaints before surgery. UI status was assessed 12 months postoperatively using the cough test and the 24-hour pad test. Results UI developed within 12 months after surgery in 149 (38%) out of 392 women. No statistically significant correlation between the type of treatment and UI incidence was detected. The percentage of patients affected by UI did not differ between the study groups. Conclusions Hysterectomy constitutes a risk factor for the development of urinary incontinence but the occurrence of postoperative UI does not depend on the type of surgery.