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Katell Mevel

Centre national de la recherche scientifique

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Featured researches published by Katell Mevel.

The Journal of Urology | 2007

257: The Phosphodiesterase Type 4 Inhibitor, Rolipram, is More Efficient to Relax Detrusor Smooth Muscle in Rats with Overactive Bladder than in Control Rats

S. Oger; Delphine Behr-Roussel; Katell Mevel; Jacques Bernabé; Pierre Denys; Emmanuel Chartier-Kastler; François Giuliano

PDE4 inhibitors deserve further investigation for the treatment of OAB. Bladder strip preparation After 6 weeks of partial bladder outlet obstruction, rats were anesthetized with isoflurane. Entire bladders were excised and placed in Krebs-HEPES buffer (with the following millimolar composition : NaCl 118.0; KCl 4.7; MgSO4 1.2; KH2PO4 1.2; CaCl2 2.5; NaHCO3 4.2; glucose 11.1; HEPES 20.8; pH 7.4). The bladder dome was isolated from the trigone region and four longitudinal strips were then mounted isometrically in 5 ml organ baths filled with Krebs-HEPES buffer maintained at 37°C and continuously bubbled with 95%O2-5%CO2.

European Urology Supplements | 2007

999 THE PHOSPHODIESTERASE TYPE 4 INHIBITOR, ROLIPRAM, IS MORE EFFICIENT TO RELAX DETRUSOR SMOOTH MUSCLE IN RATS WITH OVERACTIVE BLADDER THAN IN CONTROL RATS

S. Oger; Delphine Behr-Roussel; Katell Mevel; J. Bernabé; Pierre Denys; Emmanuel Chartier-Kastler; François Giuliano

Hypothesis / aims of study Detrusor smooth muscle relaxation is mainly mediated by the cyclic adenosine monophosphate (cAMP) pathway. Elevation of cAMP levels by phophodiesterase type 4 inhibition relaxes smooth muscle of various origins. The aim of this study was to evaluate the effect of the PDE4 inhibitor rolipram on detrusor smooth muscle tone in a rat pathological model of overactive bladder (OAB) i.e with partial bladder outlet obstruction (BOO).

European Urology | 2005

Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: lack of tachyphylaxis.

D. Behr-Roussel; Diane Gorny; Katell Mevel; Stéphanie Caisey; Jacques Bernabé; Gillian Burgess; Chris Wayman; Laurent Alexandre; François Giuliano

American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2003

Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms

Delphine Behr-Roussel; Philippe Chamiot-Clerc; Jacques Bernabé; Katell Mevel; Laurent Alexandre; Michel E. Safar; François Giuliano

American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2005

Erectile dysfunction: an early marker for hypertension? a longitudinal study in spontaneously hypertensive rats

Delphine Behr-Roussel; Diane Gorny; Katell Mevel; Sandrine Compagnie; Patrick Kern; Virginie Sivan; Jacques Bernabé; Martin P. Bedigian; Laurent Alexandre; François Giuliano

American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2007

Urethral closure mechanisms during sneezing-induced stress in anesthetized female cats

Véronique Julia-Guilloteau; Pierre Denys; Jacques Bernabé; Katell Mevel; Emmanuel Chartier-Kastler; Laurent Alexandre; François Giuliano

The Journal of Urology | 2004

1611: Chronic Sildenafil Enhances Erectile Responses and Endothelium-Dependent Corporal Relaxations of Normal Rats: Lack of Tachyphylaxis

Delphine Behr-Roussel; Diane Gorny; Katell Mevel; Stéphanie Caisey; Jacques Bernabé; Gillian Burgess; Chris Wayman; Laurent Alexandre; François Giuliano; Le Kremlin Bicêtre

European Urology Supplements | 2006

PROSTATE HYPERTROPHY INDUCED BY TESTOSTERONE: EFFECT OF OXYBUTYNIN IN AN EXPERIMENTAL MODEL OF OVERACTIVE BLADDER IN CONSCIOUS RATS

V. Julia-Guilloteau; Katell Mevel; A. Oudot; J. Bernabé; Pierre Denys; Emmanuel Chartier-Kastler; Laurent Alexandre; François Giuliano

European Urology Supplements | 2007

317 URETHRAL CLOSURE MECHANISMS INDUCED BY SNEEZING IN ANAESTHETIZED FEMALE CATS

V. Julia-Guilloteau; Katell Mevel; J. Bemabé; Pierre Denys; Emmanuel Chartier-Kastler; François Giuliano

European Urology Supplements | 2006

EXPERIMENTAL EVIDENCE OF THE EFFECT OF THE INHIBITION OF PHOSPHODIESTERASE TYPE 4 BY ROLIPRAM IN CONSCIOUS RAT WITH BLADDER OUTLET OBSTRUCTION

V. Julia-Guilloteau; Katell Mevel; S. Oger; J. Bernabé; Pierre Denys; Laurent Alexandre; François Giuliano

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François Giuliano

University of Paris

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Jacques Bernabé

Centre national de la recherche scientifique

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Laurent Alexandre

Centre national de la recherche scientifique

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Delphine Behr-Roussel

Institut national de la recherche agronomique

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Pierre Denys

University of California

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Emmanuel Chartier-Kastler

University of California

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J. Bernabé

Centre national de la recherche scientifique

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Sandrine Compagnie

Institut national de la recherche agronomique

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S. Oger

Centre national de la recherche scientifique

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Stéphanie Caisey

Centre national de la recherche scientifique

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