Kateřina Sheardová
Masaryk University
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Publication
Featured researches published by Kateřina Sheardová.
Parkinsonism & Related Disorders | 2009
Michal Dufek; Markéta Hamanová; Jindřich Lokaj; David Goldemund; Irena Rektorová; Zuzana Michálková; Kateřina Sheardová; Ivan Rektor
Numerous recent findings indicate the involvement of a neuroinflammatory reaction in the neurodegeneration in idiopathic Parkinsons disease (PD). We examined 29 consecutive patients with PD, ages 54-84 years, most of whom were moderately impaired (median UPDRS 19; Hoehn-Yahr 3; MMSE 28). A series of serum biomarkers were investigated, and their levels were correlated with the degree of the motor and cognitive impairment. There were no abnormalities of IL-6, acute phase proteins (C-reactive protein, serum amyloid A, alpha 1-antitrypsin, orosomucoid, ceruloplasmin, alpha 2-macroglobulin, transferrin, prealbumin) and factors of the complement system (C1q, C1-INH, C3, C4). A decrease in Mannan-binding lectin (MBL) levels was observed in six patients; an elevation of tumor necrosis factor-alpha (TNF-alpha) was found in 12 patients. No statistically significant correlation was found between the patients clinical state (neuropsychologic and motor, as expressed by UPDRS III, Hoehn-Yahr, and MMSE) and the immunomarker changes. Our results indicate that the inflammatory process may be reflected in the serum; nevertheless, further research is needed to elucidate the possible clinical implications.
Parkinsonism & Related Disorders | 2009
Ivan Rektor; David Goldemund; Kateřina Sheardová; Irena Rektorová; Zuzana Michálková; Michal Dufek
To study the impact of brain vessel pathology on the clinical status of Parkinsons disease (PD), in 57 consecutive patients the clinical and neuropsychological data were compared with clinical MRI signs of vascular impairment and with the ultrasound brain vessel investigations. There was a significant correlation between clinical and cognitive status and intimomedial thickness, which is an indicator of large vessel impairment. Cognitive status was significantly related to the pulsatility index (an indicator of small vessel impairment). This study provides evidence that subclinical vascular pathology could influence the clinical status by contributing to motor and cognitive dysfunction in PD.
Movement Disorders | 2012
Ivan Rektor; David Goldemund; Petr Bednařík; Kateřina Sheardová; Zuzana Michálková; Sabina Telecká; Michal Dufek; Irena Rektorová
The effect of brain‐vessel pathology on mortality in 57 consecutive PD patients was studied.
Journal of Alzheimer's Disease | 2012
Alexandra Varjassyova; Daniel Hořínek; Ross Andel; Jana Amlerova; Jan Laczó; Kateřina Sheardová; Hana Magerova; Iva Holmerová; Martin Vyhnalek; Ondřej Bradáč; Yonas E. Geda; Jakub Hort
We examined whether recognition of facial emotional expression would be affected in amnestic mild cognitive impairment (aMCI). A total of 50 elderly persons met the initial inclusion criteria; 10 were subsequently excluded (Geriatric Depression Score > 5). 22 subjects were classified with aMCI based on published criteria (single domain aMCI [SD-aMCI], n = 10; multiple domain aMCI [MD-aMCI], n = 12); 18 subjects were cognitively normal. All underwent standard neurological and neuropsychological evaluations as well as tests of facial emotion recognition (FER) and famous faces identification (FFI). Among normal controls, FFI was negatively correlated with Mini-Mental Status Examination scores and positively correlated with executive function. Among patients with aMCI, FER was correlated with attention/speed of processing. No other correlations were significant. In a multinomial logistic regression model adjusted for age, gender, and education, a poorer score on FER, but not on FFI, was associated with greater odds of being classified as MD-aMCI (odds ratio [OR], 3.82; 95% confidence interval [CI], 1.05-13.91; p = 0.042). This association was not explained by memory or global cognitive score. There was no association between FER or FFI and SD-aMCI (OR, 1.13; 95% CI, 0.36-3.57; p = 0.836). Therefore, FER, but not FFI, may be impaired in MD-aMCI. This implies that in MD-aMCI, the tasks of FER and FFI may involve segregated neurocognitive networks.
Ceskoslovenska Psychologie | 2009
Zuzana Hummelová; Irena Rektorová; Kateřina Sheardová; Ales Bartos; Vladimír Línek; Pavel Ressner; Jana Zapletalova; Martin Vyhnalek; Jakub Hort
Československá psychologie (Czechoslovak Psychology) | 2017
Rafal Marciniak; Jan Šerek; Kateřina Sheardová; Dan Hudeček; Jakub Hort
Journal of the Neurological Sciences | 2017
Jiri Cerman; Jan Laczó; Martin Vyhnalek; Kateřina Sheardová; J. Ferda; O. Belohlavek; J. Hanzalova; Z. Chmatalova; J. Hort
Neurologie pro praxi | 2016
Kateřina Sheardová; Daniel Hudeček; Olga Hromková; Rafal Marciniak; Jakub Hort
Journal of the Neurological Sciences | 2013
Ivan Rektor; David Goldemund; Petr Bednařík; Kateřina Sheardová; Zuzana Michálková; Sabina Telecká; Michal Dufek; Irena Rektorová
Journal of the Neurological Sciences | 2013
Jan Laczó; Ross Andel; I. Gažová; Ivana Mokrisova; Kamil Vlcek; Martin Vyhnalek; Eva Hyncicova; Ondřej Lerch; Jiri Cerman; L. Pecháčková; Kateřina Sheardová; J. Hort