Katharine R. Boucot

The histopathology of bronchogenic carcinoma and its relation to growth rate, metastasis, and prognosis

During the course of a prospective study in which 6,136 older men were examined by photofluorogram and questionnaire every 6 months, 179 developed proved bronchogenic carcinoma. Histologic sections were obtained in 161 cases and classified by a panel of 3 pathologists using a modified World Health Organization classification. The panel agreed with the diagnoses made by the hospital pathologists in most of those originally classified as squamous cell or adenocarcinoma but classified 30% of the undifferentiated carcinomas as squamous cell tumors. The panelists placed most of these in the anaplastic subgroup (lc). Unanimity was highest for squamous cell carcinoma and within this group the extent of agreement was best for the most highly differentiated subgroup (la). Five‐year survival rates were poor (10%), but equal for men with squamous cell and adenocarcinoma. These findings can be explained by the biologic character of the cancer types; squamous cell carcinomas have rapid growth rates and moderate metastatic potential, while adenocarcinomas have slow growth rates but high metastatic potential.

THE PHILADELPHIA PULMONARY NEOPLASM RESEARCH PROJECT: AN INTERIM REPORT

Excerpt The Philadelphia Pulmonary Neoplasm Research Project was begun in 1951, primarily to study the natural history of lung cancer with special emphasis on the chronologic relationship between s...

Operative Mortality and 5-Year Survival Rates in Men with Bronchogenic Carcinoma

Abstract Twelve teaching hospitals in Philadelphia reported histologically proved cases of bronchogenic carcinoma to the County Medical Society Subcommittee on Lung Cancer from 1956 to 1965. A stud...

CHEST X-RAY SURVEYS IN GENERAL HOSPITALS, A CRITICAL REVIEW

Excerpt Roentgenographic chest surveys of general hospital populations are fairly recent innovations. In 1936, Hodges4reported a chest x-ray survey of 1101 admissions to the University of Michigan ...