Katherine Fong

How early are fetal cerebral sulci visible at prenatal ultrasound and what is the normal pattern of early fetal sulcal development

To evaluate the time of appearance and pattern of development of fetal cerebral sulci at prenatal ultrasound.

Prenatal ultrasound findings of lissencephaly associated with Miller–Dieker syndrome and comparison with pre‐ and postnatal magnetic resonance imaging

To report on the prenatal ultrasound findings in fetuses with lissencephaly associated with Miller–Dieker syndrome (MDS) and to compare these findings with those of magnetic resonance imaging (MRI).

Retrospective review of diagnostic performance of intracranial translucency in detection of open spina bifida at the 11–13‐week scan

To evaluate diagnostic performance of intracranial translucency (IT) for detection of open spina bifida and interobserver agreement for visualization of IT during the 11–13‐week scan.

Fetal anatomic survey using three‐dimensional ultrasound in conjunction with first‐trimester nuchal translucency screening

To determine the visualization rates of fetal anatomic structures by three‐dimensional ultrasound (3DUS) at 12–13 weeks of gestation.

Fetal ventriculomegaly secondary to isolated large choroid plexus cysts: prenatal findings and postnatal outcome

To report the prenatal findings and postnatal outcome of fetal ventriculomegaly associated with isolated large choroid plexus cysts (CPCs).

Prospective study of intracranial translucency and the posterior brain in normal fetuses at the 11- to 13-week scan.

To evaluate the ability of sonographers to prospectively identify intracranial translucency and posterior brain structures at 11 to 13 weeks and to evaluate measurement reproducibility of brain stem and brain stem–occipital bone diameters on stored images.

OP15.02: Interobserver agreement and diagnostic performance of intracranial translucency in the detection of open neural tube defect at the 11–13 + 6 week scan

diagnosis. The registers provided information about the timing and method of diagnosis. Results: 37 cases of schizencephaly were identified in an estimated 2,568,556 live and stillbirths, giving an overall incidence of 1.48/100,000 births (95% confidence intervals 1.01–1.95/100,000 births). Seventeen of the 37 cases (46%, 95% Confidence Interval 30–62%) were identified antenatally. No affected fetus had abnormal chromosomes identified. There was a high proportion of younger mothers. The average age of mothers was 22.34 years (95% confidence interval 20.4–24.3). 22 of the mothers were aged 24 or less (59%: 95% confidence interval 44–75%). In England and Wales between 1998 and 2008 the average age of mothers of live births was 29.3 years, and 26% occurred to mothers aged 24 or less (P < 0.0001). Only three cases were identified before 21 weeks gestation. Additional anomalies associated with vascular disruption sequences were found in nine cases, one of which had gastroschisis and eight had septo-optic dysplasia or absent septum pellucidum. Conclusions: Schizencephaly occurs more frequently in younger mothers. It is often associated with septo-optic dysplasia, which also occurs more commonly in younger mothers, and the two conditions may share a common origin, arising as a result of vascular disruption affecting the tributaries of the circle of Willis that causes changes which only become apparent on ultrasound in the second half of pregnancy.

OC12.07: Early (15–20 week) ultrasound findings in type‐2 cobblestone cortex lissencephaly

A. Toi1, K. Fong1, D. Chitayat2, P. Shannon4, S. Blaser3 1Medical Imaging, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; 2Prenatal Diagnosis and Medical Genetics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; 3Neuroradiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; 4Neuropathology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

Nonisolated diaphragmatic hernia in Simpson‐Golabi‐Behmel syndrome

Congenital diaphragmatic hernia (CDH) is associated with Simpson‐Golabi‐Behmel syndrome (SGBS), but few cases diagnosed prenatally have been reported. The aim of this series is to highlight the association of nonisolated CDH with SGBS type I on prenatal ultrasound and emphasize the importance of genetic testing, fetal autopsy, and family history in confirming this diagnosis.

OC15.05: Prospective study of intracranial translucency and posterior fossa in normal fetuses at 11–13 weeks gestation

I. Kirkegaard1, C. K. Ekelund2, S. Ball3, P. Newell3, D. Wright3, P. Noergaard4, S. Soerensen5, L. Friis-Hansen6, N. Toerring7, N. Uldbjerg1, A. Tabor2, O. B. Petersen1, F. S. Jørgensen4 1Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark; 2Fetal Medicine Unit, Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 3School of Computing and Mathematics, University of Plymouth, Plymouth, United Kingdom; 4Fetal Medicine Unit, Department of Obstetrics and Gynecology, Hvidovre, Copenhagen University Hospital, Copenhagen, Denmark; 5Department of Clinical Biochemistry, Hvidovre, Copenhagen University Hospital, Copenhagen, Denmark; 6Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 7Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark