Kathleen Ward Brown

Ambient gas concentrations and personal particulate matter exposures: implications for studying the health effects of particles.

Background: Data from a previous study conducted in Baltimore, MD, showed that ambient fine particulate matter less than 2.5 &mgr;m in diameter (PM2.5) concentrations were strongly correlated with corresponding personal PM2.5 exposures, whereas ambient O3, NO2, and SO2 concentrations were weakly correlated with their personal exposures to these gases. In contrast, many of the ambient gas concentrations were reasonable surrogates of personal PM2.5 exposures. Methods: Personal multipollutant exposures and corresponding ambient air pollution concentrations were measured for 43 subjects living in Boston, MA. The cohort consisted of 20 healthy senior citizens and 23 schoolchildren. Simultaneous 24-hour integrated PM2.5, O3, NO2, and SO2 personal exposures and ambient concentrations were measured. All PM2.5 samples were also analyzed for SO42− (sulfate). We analyzed personal exposure and ambient concentration data using correlation and mixed model regression analyses to examine relationships among (1) ambient PM2.5 concentrations and corresponding ambient gas concentrations; (2) ambient PM2.5 and gas concentrations and their respective personal exposures; (3) ambient gas concentrations and corresponding personal PM2.5 exposures; and (4) personal PM2.5 exposures and corresponding personal gas exposures. Results: We found substantial correlations between ambient PM2.5 concentrations and corresponding personal exposures over the course of time. Additionally, our results support the earlier finding that summertime gaseous pollutant concentrations may be better surrogates of personal PM2.5 exposures (especially personal exposures to PM2.5 of ambient origin) than they are surrogates of personal exposures to the gases themselves. Conclusions: Particle health effects studies that include both ambient PM2.5 and gaseous concentrations as independent variables must be analyzed carefully and interpreted cautiously, since both parameters may be serving as surrogates for PM2.5 exposures.

Factors influencing relationships between personal and ambient concentrations of gaseous and particulate pollutants

Previous exposure studies have shown considerable inter-subject variability in personal-ambient associations. This paper investigates exposure factors that may be responsible for inter-subject variability in these personal-ambient associations. The personal and ambient data used in this paper were collected as part of a personal exposure study conducted in Boston, MA, during 1999-2000. This study was one of a group of personal exposure panel studies funded by the U.S. Environmental Protection Agencys National Exposure Research Laboratory to address areas of exposure assessment warranting further study, particularly associations between personal exposures and ambient concentrations of particulate matter and gaseous co-pollutants. Twenty-four-hour integrated personal, home indoor, home outdoor and ambient sulfate, elemental carbon (EC), PM(2.5), ozone (O(3)), nitrogen dioxide (NO(2)) and sulfur dioxide were measured simultaneously each day. Fifteen homes in the Boston area were measured for 7 days during winter and summer. A previous paper explored the associations between personal-indoor, personal-outdoor, personal-ambient, indoor-outdoor, indoor-ambient and outdoor-ambient PM(2.5), sulfate and EC concentrations. For the current paper, factors that may affect personal exposures were investigated, while controlling for ambient concentrations. The data were analyzed using mixed effects regression models. Overall personal-ambient associations were strong for sulfate during winter (p<0.0001) and summer (p<0.0001) and PM(2.5) during summer (p<0.0001). The personal-ambient mixed model slope for PM(2.5) during winter but was not significant at p=0.10. Personal exposures to most pollutants, with the exception of NO(2), increased with ventilation and time spent outdoors. An opposite pattern was found for NO(2) likely due to gas stoves. Personal exposures to PM(2.5) and to traffic-related pollutants, EC and NO(2), were higher for those individuals living close to a major road. Both personal and indoor sulfate and PM(2.5) concentrations were higher for homes using humidifiers. The impact of outdoor sources on personal and indoor concentrations increased with ventilation, whereas an opposite effect was observed for the impact of indoor sources.

Characterization of Particulate Matter for Three Sites in Kuwait

Abstract Many studies have shown strong associations between particulate matter (PM) levels and a variety of health outcomes, leading to changes in air quality standards in many regions, especially the United States and Europe. Kuwait, a desert country located on the Persian Gulf, has a large petroleum industry with associated industrial and urban land uses. It was marked by environmental destruction from the 1990 Iraqi invasion and subsequent oil fires. A detailed particle characterization study was conducted over 12 months in 2004–2005 at three sites simultaneously with an additional 6 months at one of the sites. Two sites were in urban areas (central and southern) and one in a remote desert location (northern). This paper reports the concentrations of particles less than 10 µm in diameter (PM10) and fine PM (PM2.5), as well as fine particle nitrate, sulfate, elemental carbon (EC), organic carbon (OC), and elements measured at the three sites. Mean annual concentrations for PM10 ranged from 66 to 93 µg/m3 across the three sites, exceeding the World Health Organization (WHO) air quality guidelines for PM10 of 20 µg/m3. The arithmetic mean PM2.5 concentrations varied from 38 and 37 µg/m3 at the central and southern sites, respectively, to 31 µg/m3 at the northern site. All sites had mean PM2.5 concentrations more than double the U.S. National Ambient Air Quality Standard (NAAQS) for PM2.5. Coarse particles comprised 50–60% of PM10. The high levels of PM10 and large fraction of coarse particles comprising PM10 are partially explained by the resuspension of dust and soil from the desert crust. However, EC, OC, and most of the elements were significantly higher at the urbanized sites, compared with the more remote northern site, indicating significant pollutant contributions from local mobile and stationary sources. The particulate levels in this study are high enough to generate substantial health impacts and present opportunities for improving public health by reducing airborne PM.

Source apportionment of fine particles in Kuwait City

This study investigated major sources of PM2.5 in the atmosphere of Kuwait based on a sampling program conducted between February 2004 and October 2005. Three source identification techniques were used in this study: (1) a positive matrix factorization model; (2) backward trajectory profiles; and (3) concentration rose plots. Five major sources of PM2.5 were estimated. These were sand dust (sand storms), oil combustion (power plants), petrochemical industry (fertilizer, nylon or catalyst regeneration facilities), traffic (vehicle emissions and road dust) and transported emissions (emissions from outside Kuwait, such as those from automobiles, road dust or smelters). The estimated contributions to PM2.5 of these sources were: 54% from sand dust, 18% from oil combustion, 12% from petrochemical industry, 11% from traffic and 5% from anthropogenic sources transported from outside the country. Oil combustion, petrochemical industry and traffic were found to emanate from local sources, whereas sand dust and some emissions from traffic, and possibly smelters, appeared to originate from sources outside of Kuwait (transported). The PM2.5 levels in Kuwait during our previous sampling study averaged 53μg/m(3). More than half of the measured PM2.5 appears to have been due to crustal material, much originating outside of the country. However, the relatively high levels of PM2.5 contributed by anthropogenic local sources, such as oil combustion, petrochemical industry emissions, and traffic indicated that there may be great opportunities for Kuwait to improve public health. The application of cost-effective emission controls and development of forward looking environmental health policies have the potential to significantly reduce emissions, population exposures to PM2.5 and the burden of mortality and morbidity from air pollution.

Concentrations of PM 2.5 mass and components in residential and non-residential indoor microenvironments: The Sources and Composition of Particulate Exposures study

Although short in duration, air pollutant exposures occurring in non-residential microenvironments (MEs), including restaurants, vehicles and commercial locations, can represent a large fraction of total personal exposures. For the Sources and Composition of Particulate Exposures study, a novel compact sampling system was developed, facilitating simultaneous measurement of highly speciated PM2.5 mass in a range of commercial and residential locations. This sampler also included 1-min measurements of PM2.5 mass and ultrafine particle (UFP) counts. Sampling was conducted in a number of MEs (retail stores, restaurants and vehicles) throughout Atlanta. Chemically resolved particulate measurements in these locations are of interest for both exposure scientists and epidemiologists but have typically not been conducted because of logistical constraints associated with sampling these trace constituents. We present measurements from a non-random sample of locations that are limited in their generalizability but provide several promising hypothesis-generating results. PM2.5 mass concentrations greater than 100  μg/m3, and UFPs>105 particles /cm3 were measured during several events in the restaurant and vehicle. Somewhat unexpectedly, the grocery store ME, along with the restaurant and vehicle, also had the highest levels of elemental carbon (EC), organic carbon (OC) and most elements. In-vehicle concentrations of soil-related elements (Al, Ca, Fe, K and Ti) and auto-related elements (EC, OC, Zn and Cu) were higher than those measured at a central ambient site. The lowest concentrations for most pollutants were found in the hospital and retail locations. It is questionable whether periodic, high PM concentrations in the grocery store and restaurant pose health risks for customers; however, individuals working in these locations may be exposed to levels of concern.

Reducing patients’ exposures to asthma and allergy triggers in their homes: an evaluation of effectiveness of grades of forced air ventilation filters

Abstract Objective: Many interventions to reduce allergen levels in the home are recommended to asthma and allergy patients. One that is readily available and can be highly effective is the use of high performing filters in forced air ventilation systems. Methods: We conducted a modeling analysis of the effectiveness of filter-based interventions in the home to reduce airborne asthma and allergy triggers. This work used “each pass removal efficiency” applied to health-relevant size fractions of particles to assess filter performance. We assessed effectiveness for key allergy and asthma triggers based on applicable particle sizes for cat allergen, indoor and outdoor sources of particles <2.5 µm in diameter (PM2.5), and airborne influenza and rhinovirus. Results: Our analysis finds that higher performing filters can have significant impacts on indoor particle pollutant levels. Filters with removal efficiencies of >70% for cat dander particles, fine particulate matter (PM2.5) and respiratory virus can lower concentrations of those asthma triggers and allergens in indoor air of the home by >50%. Very high removal efficiency filters, such as those rated a 16 on the nationally recognized Minimum Efficiency Removal Value (MERV) rating system, tend to be only marginally more effective than MERV12 or 13 rated filters. Conclusions: The results of this analysis indicate that use of a MERV12 or higher performing air filter in home ventilation systems can effectively reduce indoor levels of these common asthma and allergy triggers. These reductions in airborne allergens in turn may help reduce allergy and asthma symptoms, especially if employed in conjunction with other environmental management measures recommended for allergy and asthma patients.

PCB remediation in schools: a review

Growing awareness of polychlorinated biphenyls (PCBs) in legacy caulk and other construction materials of schools has created a need for information on best practices to control human exposures and comply with applicable regulations. A concise review of approaches and techniques for management of building-related PCBs is the focus of this paper. Engineering and administrative controls that block pathways of PCB transport, dilute concentrations of PCBs in indoor air or other exposure media, or establish uses of building space that mitigate exposure can be effective initial responses to identification of PCBs in a building. Mitigation measures also provide time for school officials to plan a longer-term remediation strategy and to secure the necessary resources. These longer-term strategies typically involve removal of caulk or other primary sources of PCBs as well as nearby masonry or other materials contaminated with PCBs by the primary sources. The costs of managing PCB-containing building materials from assessment through ultimate disposal can be substantial. Optimizing the efficacy and cost-effectiveness of remediation programs requires aligning a thorough understanding of sources and exposure pathways with the most appropriate mitigation and abatement methods.

Potential Effectiveness of Point-of-Use Filtration to Address Risks to Drinking Water in the United States:

Numerous contemporary incidents demonstrate that conventional control strategies for municipal tap water have limited ability to mitigate exposures to chemicals whose sources are within distribution systems, such as lead, and chemicals that are not removed by standard treatment technologies, such as perfluorooctanoic acid (PFOA)/perfluorooctanesulfonic acid (PFOS). In these situations, point-of-use (POU) controls may be effective in mitigating exposures and managing health risks of chemicals in drinking water, but their potential utility has not been extensively examined. As an initial effort to fill this information gap, we conducted a critical review and analysis of the existing literature and data on the effectiveness of POU drinking water treatment technologies for reducing chemical contaminants commonly found in tap water in the United States. We found that many types of water treatment devices available to consumers in the United States have undergone laboratory testing and often certification for removal of chemical contaminants in tap water, but in most cases their efficacy in actual use has yet to be well characterized. In addition, the few studies of POU devices while “in use” focus on traditional contaminants regulated under the Safe Drinking Water Act, but do not generally consider nontraditional contaminants of concern, such as certain novel human carcinogens, industrial chemicals, pesticides, pharmaceuticals, personal care products, and flame retardants. Nevertheless, the limited information available at present suggests that POU devices can be highly effective when used prophylactically and when deployed in response to contamination incidents. Based on these findings, we identify future areas of research for assessing the ability of POU filters to reduce health-related chemical contaminants distributed through public water systems and private wells.

A case study of potential human health impacts from petroleum coke transfer facilities.

ABSTRACT Petroleum coke or “petcoke” is a solid material created during petroleum refinement and is distributed via transfer facilities that may be located in densely populated areas. The health impacts from petcoke exposure to residents living in proximity to such facilities were evaluated for a petcoke transfer facilities located in Chicago, Illinois. Site-specific, margin of safety (MOS) and margin of exposure (MOE) analyses were conducted using estimated airborne and dermal exposures. The exposure assessment was based on a combined measurement and modeling program that included multiyear on-site air monitoring, air dispersion modeling, and analyses of soil and surfaces in residential areas adjacent to two petcoke transfer facilities located in industrial areas. Airborne particulate matter less than 10 microns (PM10) were used as a marker for petcoke. Based on daily fence line monitoring, the average daily PM10 concentration at the KCBX Terminals measured on-site was 32 μg/m3, with 89% of 24-hr average PM10 concentrations below 50 μg/m3 and 99% below 100 μg/m3. A dispersion model estimated that the emission sources at the KCBX Terminals produced peak PM10 levels attributed to the petcoke facility at the most highly impacted residence of 11 μg/m3 on an annual average basis and 54 μg/m3 on 24-hr average basis. Chemical indicators of petcoke in soil and surface samples collected from residential neighborhoods adjacent to the facilities were equivalent to levels in corresponding samples collected at reference locations elsewhere in Chicago, a finding that is consistent with limited potential for off-site exposure indicated by the fence line monitoring and air dispersion modeling. The MOE based upon dispersion model estimates ranged from 800 to 900 for potential inhalation, the primary route of concern for particulate matter. This indicates a low likelihood of adverse health effects in the surrounding community. Implications: Handling of petroleum coke at bulk material transfer facilities has been identified as a concern for the public health of surrounding populations. The current assessment, based on measurements and modeling of two facilities located in a densely populated urban area, indicates that petcoke transport and accumulation in off-site locations is minimal. In addition, estimated human exposures, if any, are well below levels that could be anticipated to produce adverse health effects in the general population.