Kathryn Robinson
Dharmacon, Inc.
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Publication
Featured researches published by Kathryn Robinson.
Nature Methods | 2006
Amanda Birmingham; Emily Anderson; Angela Reynolds; Diane Ilsley-Tyree; Devin Leake; Yuriy Fedorov; Scott Baskerville; Elena Maksimova; Kathryn Robinson; Jon Karpilow; William Marshall; Anastasia Khvorova
Off-target gene silencing can present a notable challenge in the interpretation of data from large-scale RNA interference (RNAi) screens. We performed a detailed analysis of off-targeted genes identified by expression profiling of human cells transfected with small interfering RNA (siRNA). Contrary to common assumption, analysis of the subsequent off-target gene database showed that overall identity makes little or no contribution to determining whether the expression of a particular gene will be affected by a given siRNA, except for near-perfect matches. Instead, off-targeting is associated with the presence of one or more perfect 3′ untranslated region (UTR) matches with the hexamer or heptamer seed region (positions 2–7 or 2–8) of the antisense strand of the siRNA. These findings have strong implications for future siRNA design and the application of RNAi in high-throughput screening and therapeutic development.
RNA | 2006
Yuriy Fedorov; Emily Anderson; Amanda Birmingham; Angela Reynolds; Jon Karpilow; Kathryn Robinson; Devin Leake; William Marshall; Anastasia Khvorova
RNA | 2006
Angela Reynolds; Emily Anderson; Annaleen Vermeulen; Yuriy Fedorov; Kathryn Robinson; Devin Leake; Jon Karpilow; William Marshall; Anastasia Khvorova
Archive | 2005
Barbara Robertson; Devin Leake; Kathryn Robinson; William Marshall; Anastasia Khvorova
Archive | 2005
Barbara Robertson; Devin Leake; Kathryn Robinson; William Marshall; Anastasia Khvorova
Archive | 2005
Barbara Robertson; Devin Leake; Kathryn Robinson; William Marshall; Anastasia Khvorova
Archive | 2005
Barbara Robertson; Devin Leake; Kathryn Robinson; William Marshall; Anastasia Khvorova
Nature Methods | 2006
Amanda Birmingham; Emily Anderson; Angela Reynolds; Diane Ilsley-Tyree; Devin Leake; Yuriy Fedorov; Scott Baskerville; Elena Maksimova; Kathryn Robinson; Jon Karpilow; William Marshall; Anastasia Khvorova
Archive | 2005
Barbara Robertson; Devin Leake; Kathryn Robinson; William Marshall; Anastasia Khvorova
Archive | 2005
Barbara Robertson; Devin Leake; Kathryn Robinson; William Marshall; Anastasia Khvorova