Kathyrne Mueller

Another look at amphetamine-induced stereotyped locomotor activity in rats using a new statistic to measure locomotor stereotypy

AbstractRat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animals path through the open field is converted into a series of trips. Gamma (

Time course of amphetamine-induced locomotor stereotypy in an open field

\hat \gamma

Locomotor stereotypy is produced by methylphenidate and amfonelic acid and reduced by haloperidol but not clozapine or thioridazine

) estimates the probability that the animal will repeat the trip that it has just exhibited; thus

Repeated pemoline produces self-injurious behavior in adult and weanling rats

\hat \gamma

Scopolamine produces locomotor stereotypy in an open field but apomorphine does not

quantifies “locomotor stereotypy”. Trip lengths can also be compared across drug groups. Thus caffeine has no effect on