Katie Watts

Exercise Training in Obese Children and Adolescents Current Concepts

AbstractChildhood obesity has reached epidemic proportions worldwide and is associated with increased cardiovascular mortality and morbidity in adult life. The increase in fat mass in children and adolescents has occurred concomitantly with a decline in reported time for exercise. Evidence suggests that non-physically active children are more likely to become non-physically active adults and that encouraging the development of physical activity habits in children helps establish patterns that continue into adulthood. Dietary treatment of obesity is relatively ineffective in adults and it has been suggested that prevention of obesity in childhood and adolescence should emphasise increased physical activity rather than diet because of fears relating to the adverse effects of inappropriate eating patterns. Despite this, there are very few randomised controlled studies investigating the efficacy of exercise training in obese children or adolescents and many of the extant studies have been poorly controlled and have not specifically stratified the independent effect of exercise versus dietary modification.This review focuses on the well designed controlled trials that have evaluated the effect of exercise training in obese children and adolescents on body composition, haemodynamic and metabolic variables, cardiovascular fitness, muscular strength and vascular function. These studies indicate that, although exercise training does not consistently decrease bodyweight or body mass index, it is associated with beneficial changes in fat and lean body mass, emphasising the importance of comprehensive assessment of body composition in future exercise-training studies. Exercise training improves cardiovascular fitness and muscular strength; however, it seems to have little effect on blood lipid profile or blood pressure in obese young people. Importantly, recent studies have demonstrated that exercise training improves vascular endothelial function, an important surrogate measure that may predict future atherosclerotic risk in obese children and adolescents. Given that improvement in vascular function in these training studies occurred in the absence of changes in lipid fractions, haemodynamic variables or glucose metabolism, exercise appears to have a direct beneficial effect on the vasculature, in addition to its putative benefits through risk-factor modification.

Lack of effect of oral glucose loading on conduit vessel endothelial function in healthy subjects

The aim of the present study was to investigate the impact of an oral glucose load on circulating insulin and glucose levels and arterial function in healthy non-diabetic subjects. Thirty-nine non-obese, healthy subjects (24 female, 15 male), aged 21.0+/-1.8 years of age, were randomly assigned to undergo either an OGTT (oral glucose tolerance test; 75 g of glucose) or administration of a placebo. Analyses of lipids, liver function and HbA(1c) (glycated haemoglobin) at baseline revealed results which were within the standard reference range. Insulin and glucose levels as well as vascular function [FMD (flow-mediated dilation)] were measured at 0, 60 and 120 min. Compared with baseline, the control subjects did not exhibit any significant changes in glucose or insulin levels, whereas, in the OGTT group, blood glucose levels at both 60 (5.4+/-1.7 mmol/l) and 120 (5.0+/-1.1 mmol/l) min increased significantly relative to baseline (4.1+/-0.4 mmol/l; both P<0.001) and, similarly, insulin levels were higher at both 60 (30.1+/-21.3 m-units/l) and 120 (34.9+/-23.6 m-units/l) min compared with baseline (4.7+/-4.3 m-units/l; both P<0.001). Although blood glucose and insulin levels changed, FMD did not significantly differ between time-points or between groups. In summary, despite significantly elevated glucose and insulin concentrations in these subjects, we observed no change in vascular function, suggesting that acute elevations of glucose and insulin within the clinically normal range are not associated with impaired vascular function in vivo.

A comparison of ambulatory oxygen consumption during circuit training and aerobic exercise in patients with chronic heart failure.

PURPOSE This study compared the exercise intensity of a combined aerobic and resistance exercise circuit training session with the exercise intensity of continuous aerobic exercise in patients with chronic heart failure (CHF). METHODS Peak oxygen consumption (VO2peak) and muscular strength (1 repetition maximum) were assessed in six CHF patients (age 62 +/- 3 years). Heart rate, rate of perceived exertion (RPE), blood pressures, ambulatory oxygen consumption (VO2), and ventilatory data were measured during two types of exercise: continuous cycling on a bicycle ergometer (aerobic [AER] session) and combined AER and resistance exercise (circuit training [CIR] session). RESULTS There were no significant differences in VO2, RPE, heart rate, or hemodynamic responses (rate pressure product, diastolic blood pressure, or mean arterial pressure) during exercise, between the two sessions. Systolic blood pressure was significantly lower during CIR (P < 0.05). Minute ventilation and tidal volume were significantly higher (P < 0.0001 and P < 0.01, respectively) and respiratory frequency significantly lower (P < 0.005) during CIR. During CIR, RPE significantly correlated with VO2 (P < 0.01), whereas heart rate did not. Conversely, during the AER session HR correlated with VO2 (P < 0.01), but RPE did not. CONCLUSIONS Circuit training is a well-tolerated form of exercise training for CHF patients that is associated with similar oxygen and hemodynamic demand to aerobic exercise. Results suggest that RPE may be a better method of prescribing and monitoring exercise intensity during CIR, with heart rate the preferred measure of intensity during aerobic exercise.