Katleen Vandenberghe
Katholieke Universiteit Leuven
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Featured researches published by Katleen Vandenberghe.
Medicine and Science in Sports and Exercise | 1999
Katleen Vandenberghe; Paul Van Hecke; Marc Van Leemputte; Florent Vanstapel; Peter Hespel
PURPOSE Oral creatine supplementation has been shown to improve power output during high intensity intermittent muscle contractions. Facilitated muscle phosphocreatine (PCr) resynthesis, by virtue of elevated intracellular PCr concentration, might contribute to this ergogenic action. Therefore, the effect of creatine loading (C: 25 g X d(-1) for 5 d) on muscle PCr breakdown and resynthesis and muscle performance during high intensity intermittent muscle contractions was investigated. METHODS A double-blind randomized cross-over study was performed in young healthy male volunteers (N = 9). 31P-NMR spectroscopy of the m. gastrocnemius and isokinetic dynamometry of knee-extension torque were performed before and after 2 and 5 d of either placebo (P) or C administration. RESULTS Compared with P, 2 and 5 d of C increased (P < 0.05) resting muscle PCr concentration by 11% and 16%, respectively. Furthermore, torque production during maximal intermittent knee extensions, including the first bout of contractions, was increased (P < 0.05) by 5-13% by either 2 or 5 d of C. However, compared with P, the rate of PCr breakdown and resynthesis during intermittent isometric contractions of the calf was not significantly affected by C. CONCLUSION Creatine loading raises muscle PCr concentration and improves performance during rapid and dynamic intermittent muscle contractions. Creatine loading does not facilitate muscle PCr resynthesis during intermittent isometric muscle contractions.
Diabetes | 1995
Peter Hespel; Lieven Vergauwen; Katleen Vandenberghe; Erik A. Richter
The relative role of contractions, insulin, and increased supply of glucose and insulin, via an increase in blood flow, in stimulating glucose uptake in skeletal muscle during contractions was studied in isolated perfused rat hindlimbs. ffindlimbs were perfused with a standard per-fusate medium containing 6 mmol/1 glucose and four different insulin concentrations (0, 100, 500, and 20,000 μU/ml). Contractions were induced by supramaximal intermittent electrical stimulation of the sciatic nerve. Three different perfusion protocols were used: 1) muscles were stimulated to contract without concomitantly increasing perfusate flow; 2) flow was increased in the absence of electrical stimulation; and 3) muscles were stimulated to contract together with a flow increase. Both contractions and increased flow of perfusate, applied as separate stimuli, increased (P < 0.05) glucose uptake in the absence of insulin. Yet when submaximal insulin concentrations were added to the perfusate, the stimulatory action of both contractions and increased blood flow on muscle glucose uptake was augmented. The higher the submaximal insulin concentration, the greater the increment (P < 0.05). This effect, however, faded at supra-maximal insulin concentration. Electrical stimulation associated with an increase in perfusion flow rate produced a greater (P < 0.05) rise in glucose uptake than did contractions alone. In fact, stimulation of muscle glucose uptake by contractions and increased flow proved to be additive at any insulin concentration. We conclude that contractions and increased blood flow act as additional stimuli to muscle glucose uptake at any insulin concentration. Furthermore, insulin appears to be a major contributor to stimulating glucose uptake rate in muscle during contractions by facilitating both the flow-induced and the contraction-induced increment in muscle glucose uptake.
Diabetes | 1996
Peter Hespel; Lieven Vergauwen; Katleen Vandenberghe; Ea Richter
Glucose uptake rate in active skeletal muscles is markedly increased during exercise. This increase reflects a multifactorial process involving both local and systemic mechanisms that cooperate to stimulate glucose extraction and glucose delivery to the muscle cells. Increased glucose extraction is effected primarily via mechanisms exerted within the muscle cell related to the contractile activity per se. Yet contractions become a more potent stimulus of muscle glucose uptake as the plasma insulin level is increased. In addition, enhanced glucose delivery to muscle, which during exercise is essentially effected via increased blood flow, significantly contributes to stimulate glucose uptake. Again, however, increased glucose delivery appears to be a more potent stimulus of muscle glucose uptake as the circulating insulin level is increased. Furthermore, contractions and elevated flow prove to be additive stimuli of muscle glucose uptake at any plasma insulin level. In conclusion, the extent to which muscle glucose uptake is stimulated during exercise depends on various factors, including 1) the intensity of the contractile activity, 2) the magnitude of the exercise-associated increase in muscle blood flow, and 3) the circulating insulin level.
Journal of Applied Physiology | 1997
Katleen Vandenberghe; Marina Goris; P. Van Hecke; M. Van Leemputte; L. Vangerven; Peter Hespel
Journal of Applied Physiology | 1996
Katleen Vandenberghe; N. Gillis; M. Van Leemputte; P. Van Hecke; Florent Vanstapel; Peter Hespel
Journal of Applied Physiology | 1999
M. Van Leemputte; Katleen Vandenberghe; Peter Hespel
International Journal of Sports Medicine | 1998
F. Vandebuerie; B. Vanden Eynde; Katleen Vandenberghe; Peter Hespel
Acta Physiologica Scandinavica | 1999
Katleen Vandenberghe; Ea Richter; Peter Hespel
Archive | 1996
Gaston Beunen; Johan Lefevre; Albrecht Claessens; Hermine Maes; Roland Renson; Jan Simons; Bavo Vanden Eynde; Bart Vanreusel; Roeland Lysens; Katleen Vandenberghe; Claire Sneyers
Creatine: from basic science to clinical application / ed. by Rodolfo Paoletti; A. Poli; Ann S. Jackson. - Dordrecht: Kluwer Academic | 2000
Peter Hespel; Bert O. Eijnde; Katleen Vandenberghe; Marc Van Leemputte