Katrina Chau
University of Sydney
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Publication
Featured researches published by Katrina Chau.
Journal of Human Hypertension | 2017
Katrina Chau; Annemarie Hennessy; Angela Makris
Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth. Mechanisms by which PlGF expression is regulated continue to be investigated. Low circulating PlGF precedes the manifestation of clinical disease in pre-eclamptic pregnancies and intrauterine growth restriction. This suggests that low PlGF is a marker of abnormal placentation, but it remains uncertain whether this is a cause or consequence. Prediction of pre-eclampsia using PlGF is promising and may assist in the targeting of resources to women at highest risk of adverse pregnancy outcomes. Promisingly, experimental animal models of pre-eclampsia have been successfully treated with supplemental PlGF. Treatment of pre-eclampsia with PlGF is a potential therapeutic option requiring further exploration. This review focuses specifically on the role of PlGF in normal and pathological placental development and in the clinical management of pre-eclampsia.
Ndt Plus | 2012
Katrina Chau; Jim L.C. Yong; Kasim Ismail; Neil Griffith; Michael Liu; Angela Makris
Granulomatous interstitial nephritis (GIN) is an uncommon cause of renal failure, which may be caused by drugs. Levetiracetam is an increasingly used anti-epileptic medication that is not known to cause renal toxicity in adults. To our knowledge, levetiracetam has not previously been reported as a cause of GIN. We report the case of a 69-year-old woman who developed haemodialysis-requiring acute renal failure after commencement of treatment with levetiracetam, which was shown to be GIN by renal biopsy. She made a complete recovery with cessation of levetiracetam and treatment with steroids.
Journal of Reproductive Immunology | 2017
Bei Xu; Renuka Shanmugalingam; Katrina Chau; Suzanne Pears; Annemarie Hennessy; Angela Makris
Early administration of low dose acetyl salicylic acid (Aspirin) in high risk women reduces the risk of early onset preeclampsia. This study aims to investigate the effect of aspirin on trophoblast integration and the its effect on angiogenic and invasive pathways in an in-vitro model of preeclampsia. Red fluorescent-labeled human uterine myometrial microvascular endothelial cells (UtMVECs) were seeded on matrigel to form endothelial networks. Green fluorescent-labeled trophoblastic HTR-8/SVneo cells were co-cultured with the endothelial networks with/without TNF-a (0.5ng/mL) and/or aspirin (0.1mM) for 24h. Fluorescent images were captured and quantified by Image J to examine the effects of TNF-a and aspirin on the trophoblast-endothelial integration. Conditioned media were collected to measure free VEGF, PlGF and sFlt-1 by ELISA and PGF1a by Enzyme immunoassay (EIA). Cells were retrieved to examine mRNA expression of angiogenic factors (VEGF, PlGF and sFlt-1), invasion markers (MMP-2 and TIMP-1), endothelial cell activation markers (E-selectin and VCAM), eNOS and cyclooxygenase (COX)-2 by quantitative PCR. Aspirin reversed the inhibitory effect of TNF-a on trophoblast cell integration into endothelial cellular networks. TNF-a increased PGF1a production (128±11%, p<0.05), whilst aspirin reversed the TNF-a effect on PGF1a production (19±4%, p<0.01). TNF-a decreased the mRNA expression of PlGF, eNOS, MMP-2 and TIMP-1, and stimulated COX2, E-selectin and VCAM mRNA expression. Aspirin did not reverse the TNF-a effect on these molecules. Aspirin improves trophoblast cell integration into endothelial cellular networks by inhibiting the effect of TNF-a via PGI2 with no significant effect on antiangiogenic, invasive or endothelial activation markers.
Obstetric Medicine | 2013
Katrina Chau; Christopher Henderson; Alan Adno; Tim Spicer; Bruce Cleland; Angela Makris
Essential cryofibrinogenaemia is a rare disorder characterized by cryofibrinogens without cryoglobulins. Connective tissue disorders and thrombophilia are known to increase risk of pre-eclampsia, but pre-eclampsia has not previously been reported in association with cryofibrinogenaemia. We report the case of a 32-year-old woman with recurrent severe pre-eclampsia diagnosed with essential cryofibrinogenaemia.
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | 2018
Katrina Chau; Gabriele Bobek; Annemarie Hennessy; Angela Makris
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | 2018
Katrina Chau; Bei Xu; Annemarie Hennessy; Angela Makris
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | 2018
Renuka Shanmugalingam; Xia Suo Wang; Katrina Chau; Bei Xu; Gaksoo Lee; Roshika Kumar; Annemarie Hennessy; Angela Makris
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | 2018
Renuka Shanmugalingam; Xia Suo Wang; Katrina Chau; Bei Xu; Gaksoo Lee; Roshika Kumar; Annemarie Hennessy; Angela Makris
Nephrology Volume 22, Supplement 3: Abstract Book 53rd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), 4–6 September 2017, Darwin Convention Centre, Northern Territory | 2017
Katrina Chau; Bei Xu; Annemarie Hennessy; Angela Makris
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health | 2016
Renuka Shanmugalingam; Bei Xu; Katrina Chau; Shikha Aggarwal; Suzanne Pears; Annemarie Hennessy; Angela Makris