Katsuaki Nishimiya

LOCALIZATION OF MONO‐L‐ASPARTYL CHLORIN e6 (NPe6) IN MOUSE TISSUES

Abstract It is known that HpD is retained longer by malignant tissue than normal tissue and is therefore a useful material for photodynamic therapy (PDT). Currently, vigorous research is being conducted throughout the world to discover a new material which can have greater cancer cell affinity than hematoporphyrin derivative (HpD) and will be used effectively for PDT. Investigation has been conducted to determine the spectral characteristics and cancer cell affinity of NPe6, a recently developed material.

Evaluation of photodynamic therapy in gastric cancer

Twenty-eight patients with gastric cancer were treated by photodynamic therapy. Haematoporphyrin derivative was used as a photosensitizer and an argon dye laser as a light source. Histologically, all tumours were adenocarcinomas. On the basis of endoscopy, 17 cases were categorized as early-stage cancer and were classified as type IIc (10 lesions), Ha (three lesions), combined type IIc and type III (three lesions) and type I (two lesions). In 11 patients with advanced-stage cancer, endoscopy showed one case of Borrmann I, three of Borrmann II, six of Borrmann III and a single case of Borrmann IV. In the 17 patients with early-stage cancers (18 lesions), complete remission was obtained in 10 patients (11 lesions). Of 13 resected cancers complete remission was confirmed in six lesions on the basis of detailed histological examination of resected specimens. In the advanced stage tumours all 11 patients showed incomplete remissions. It is considered that an incomplete response in the early-stage cancers is due to insufficient light dosage because of the wide area of tumour, because the site of the lesion is anatomically difficult to photoradiate and because the invasion extends to the muscular layer and serosa.

Effectiveness of HPD and Radiation Therapy in Lung Cancer

The diagnostic rate of lung cancer has been improved by the development of the fiberoptic bronchoscope and this instrument has particularly promoted the detection of early stage of central type lung cancer. But therapeutic results have been unsatisfactory, partly because of difficulties in resecting cases with poor pulmonary function. On the other hand, chemotherapy and radiation therapy can have serious side effects. New therapeutic modalities are therefore required for treatment of early stage inoperable lung cancer cases.

Two cases of stage I peripheral type of adenocarcinoma of the lung detected by mass survey sputum cytology.

喀痰細胞診は中心型早期肺癌の早期発見に有用であり, 集団検診にかなり取り入れられてきている.今回著者らは胸部X線写真正面像で1例は右横隔膜陰影に, 1例は肺門部陰影に重なり, 腫瘤陰影を指摘できず, 喀痰細胞診で陽性所見を得て発見された末稍型肺癌 (clinical stage I) の2例を経験したので, 若干の文献的考察を加え報告する.最近しばしば報告されるradiological occultcancerの多くは喀痰細胞診の導入によって発見された中枢発生の肺扁平上皮癌である.このような末梢型肺腺癌が喀痰細胞診でみつかったのはまれであり, 貴重な症例である. 喀痰細胞診の重要性を改めて認識させ, 胸部正面写真のみの集団検診の問題点を提起する症例と思う.