Katsuhiro Ichikawa

Misoperation of CT Automatic Tube Current Modulation Systems with Inappropriate Patient Centering: Phantom Studies

OBJECTIVE Inappropriate patient centering on the gantry changes the size of the localizer radiographs used for CT examinations, influencing the operation of CT automatic tube current modulation because tube current is controlled with information from localizer radiographs. The purpose of this study was to examine the influence of inappropriate patient centering on the gantry isocenter on automatic tube current modulation. MATERIALS AND METHODS An elliptical phantom was scanned with four automatic tube current modulation techniques after acquisition of localizer radiographs in the horizontal and vertical directions with the phantom center shifted from the gantry isocenter in the vertical direction. After scanning, the magnification rate of the frontal localizer radiographs, tube current-time product, and image noise were examined. RESULTS On phantom studies, the magnification rate of localizer radiographs showed a linear relation to the vertical deviation of the phantom from the gantry isocenter. From 50 mm above to 50 mm below the gantry isocenter, tube current-time products ranged from 75% to 141% compared with those at the gantry isocenter. In addition, increases and decreases in the amount of image noise related to changes in tube current-time product were confirmed. CONCLUSION Inappropriate patient centering causes misoperation of automatic tube current modulation systems, in which tube current is controlled with information from localizer radiographs, and thus causes increases in tube current or image noise.

Image quality dependence on in-plane positions and directions for MDCT images

OBJECTIVE The present study was performed to examine the dependence of image quality on in-plane position and direction in computed tomography (CT) imaging using the modulation transfer function (MTF), noise power spectrum (NPS) and analysis of signal-to-noise ratio (SNR). For detailed analysis of SNR, the low-contrast detectability was compared using simulated small low-contrast objects. MATERIALS AND METHODS Three models of multidetector-row CT (MDCT) were employed. The measurement positions for MTF were set to the isocentre and several peripheral areas, and NPS and SNR were calculated for the isocentre and 128 mm off-centre. To evaluate directional dependence, the one-dimensional physical properties were measured separately in the radial and azimuthal directions. Seven radiological technologists also performed a perceptual detection study at the different in-plane positions using computer-simulated low-contrast images. RESULTS The results of MTF and SNR differed between the isocentre and the peripheral area. The MTF values also tended to decrease with distance from the isocentre, and the SNR values in the low frequency range for the peripheral area were superior to those for the isocentre. In the detection study, the low-contrast detectability in the peripheral area was 13-40% higher than the value in the isocentre. CONCLUSION The results of the present study indicated that clinical CT images have remarkable non-uniformity of image quality. Therefore, the detailed analysis performed in this study will provide useful information for the development of advanced image processing applications, such as computer-aided diagnosis (CAD) and de-noising of CT images.

MTF measurement method for medical displays by using a bar-pattern image

— A modulation-transfer-function (MTF) measurement method that uses a bar-pattern image for medical displays such as liquid-crystal displays (LCDs) and cathode-ray tubes (CRTs) has been investigated. A specific bar-pattern image on the display was acquired with a high-resolution single-lens reflex-type digital camera equipped with a close-up lens. The MTF was calculated from the amplitudes of the fundamental-frequency components, which were extracted from the profile data across the bar patterns by using Fourier analysis. Actual comparisons with the conventional line technique were performed for a medical CRT. The adequate accuracy and excellent reproducibility of the method were confirmed. Furthermore, unlike the line method, an advantageous feature which can use an input signal with sufficient amplitude was theoretically proved. Horizontal and vertical MTFs at the central position of the display area were measured up to the Nyquist frequency for several medical displays. From these measurements, this method has the capability to detect slight differences between the displays measured. This proposed method is useful in understanding and quantifying the medical displays performance due to excellent reproducibility and accuracy.

Investigation of physical image characteristics and phenomenon of edge enhancement by phase contrast using equipment typical for mammography

A technique called phase contrast mammography (PCM) has only recently been applied in clinical examination. In this application, PCM images are acquired at a 1.75 x magnification using an x-ray tube for clinical use, and then reduced to the real size of the object by image processing. The images showed enhanced object edges; reportedly, this enhancement occurred because of the refraction of x rays through a cylindrical object. The authors measured the physical image characteristics of PCM to compare the image characteristics of PCM with those of conventional mammography. More specifically, they measured the object-edge-response characteristics and the noise characteristics in the spatial frequency domain. The results revealed that the edge-response characteristics of PCM outperformed those of conventional mammography. In addition, the characteristics changed with the object-placement conditions and the object shapes. The noise characteristics of PCM were better than those of conventional mammography. Subsequently, to verify why object edges were enhanced in PCM images, the authors simulated image profiles that would be obtained if the x rays were refracted and totally reflected by using not only a cylindrical substance but also a planar substance as the object. So, they confirmed that the object edges in PCM images were enhanced because x rays were refracted irrespective of the object shapes. Further, they found that the edge enhancements depended on the object shapes and positions. It was also proposed that the larger magnification than 1.75 in the commercialized system might be more suitable for PCM. Finally, the authors investigated phase-contrast effects to breast tissues by the simulation and demonstrated that PCM would be helpful in the diagnoses of mammography.

A comparative contrast perception phantom image of brain CT study between high-grade and low-grade liquid crystal displays (LCDs) in electronic medical charts

The purpose of this study was to clarify whether non-medical-grade liquid crystal displays (LCDs) are acceptable for the soft-copy reading of brain CTs. Four kinds of color LCDs with different image quality levels were used: medical-grade LCD, low-grade general LCD calibrated with the grayscale display function (GSDF), low-grade general LCD calibrated with gamma 2.2 and a notebook personal computer display panel. In Osirixs standard window setting for brain CTs, the average CT values of brain parenchyma in 100 cases were correlated with a grayscale level ranging from 71 to 91 in a 256-step grayscale. At these gray levels, the image contrast on the two low-grade LCDs calibrated with gamma 2.2 was higher than that on the medical-grade LCD. Eleven healthy volunteers participated in the contrast perception study, which used electronically generated target phantom images that simulated subtle abnormalities with a low or high attenuation difference in brain parenchyma. The three low-grade LCDs showed correct response rates and reaction times that were superior to those of the medical-grade display. The grayscale calibrations, GSDF or gamma 2.2, are likely to be more critical than the display grade, suggesting that the use of a low-grade LCD may be acceptable in the image contrast of brain CT.

Accuracy of measuring half‐ and quarter‐value layers and appropriate aperture width of a convenient method using a lead‐covered case in X‐ray computed tomography

Determination of the half‐value layer (HVL) and quarter‐value layer (QVL) values is not an easy task in X‐ray computed tomography (CT), because a nonrotating X‐ray tube must be used, which requires the assistance of service engineers. Therefore, in this study, we determined the accuracy of the lead‐covered case method, which uses X‐rays from a rotating X‐ray tube, for measuring the HVL and QVL in CT. The lead‐covered case was manufactured from polystyrene foam and a 4 mm thick lead plate. The ionizing chamber was placed in the center of the case and aluminum filters were placed 15 cm above the aperture surface. Aperture widths of 1.0, 2.0, and 3.0 cm for a tube voltage of 110 kV and an aperture width of 2.0 cm for the tube voltages of 80 and 130 kV were used to measure exposure doses. The results of the HVL and QVL were compared with those of the conventional nonrotating method. A 2.0 cm aperture was believed to be adequate, because of its small differences in the HVL and QVL in the nonrotating method and its reasonable exposure dose level. When the 2.0 cm aperture was used, the lead‐covered case method demonstrated slightly larger HVLs and QVLs (0.03‐0.06 mm for the HVL and 0.2‐0.4 mm for the QVL) at all the tube voltage settings. However, the differences in the effective energy were 0.1‐0.3 keV; therefore, it could be negligible in an organ‐absorbed dose evaluation and a quality assurance test for CT. PACS numbers: 87.57.‐s; 87.57.Q‐; 87.57.uq

Radiation dose and physical image quality in 128-section dual-source computed tomographic coronary angiography: a phantom study

One‐hundred‐and‐twenty‐eight–section dual X‐ray source computed tomography (CT) systems have been introduced into clinical practice and have been shown to increase temporal resolution. Higher temporal resolution allows low‐dose spiral mode at a high pitch factor during CT coronary angiography. We evaluated radiation dose and physical image qualities in CT coronary angiography by applying high‐pitch spiral, step‐and‐shoot, and low‐pitch spiral modes to determine the optimal acquisition mode for clinical situations. An anthropomorphic phantom, small dosimeters, a calibration phantom, and a microdisc phantom were used to evaluate the radiation doses absorbed by thoracic organs, noise power spectrums, in‐plane and z‐axis modulation transfer functions, slice sensitivity profiles, and number of artifacts for the three acquisition modes. The high‐pitch spiral mode had the advantage of a small absorbed radiation dose, but provided low image quality. The low‐pitch spiral mode resulted in a high absorbed radiation dose of approximately 200 mGy for the heart. Although the absorbed radiation dose was lower in the step‐and‐shoot mode than in the low‐pitch spiral mode, the noise power spectrum was inferior. The quality of the in‐plane modulation transfer function differed, depending on spatial frequency. Therefore, the step‐and‐shoot mode should be applied initially because of its low absorbed radiation dose and superior image quality. PACS numbers: 87.57.‐s; 87.57.C‐; 87.57.cf; 87.57.cm; 87.57.cp; 87.57.Q‐; 87.57.qp; 87.57.uq

A New Resolution Enhancement Technology Using the Independent Sub-Pixel Driving for the Medical Liquid Crystal Displays

A new resolution enhancement technology using the independent sub-pixel driving technology was developed for the medical monochrome liquid crystal displays (LCDs). Each pixel of monochrome LCDs, which employ the color liquid crystal panels that its color filters are removed, consists of three sub-pixels. In the new LCD system implemented with this new technology, the sub-pixel intensities were modulated according to the detailed image information, and consequently resolution was enhanced three times. Thus the new technology realized a 15 mega-pixels (MP) super high-resolution LCD (SHR-LCD) out of a conventional 5 MP LCD and a 9 MP SHR-LCD out of a conventional 3 MP LCD. Physical measurements and perceptual evaluations performed in this study proved that the achieved 15 MP (through our new technology) was appropriate and efficient to depict the finer anatomical structures such as the micro calcifications in mammography.

Pleomorphic adenoma of the breast

Pleomorphic adenoma is a very rare benign tumor of the breast. Only 70 cases have been reported in the world literature. Recently, we encountered a case of pleomorphic adenoma of the breast and thus present here the mammographic and ultrasonographic findings with the pathology of this rare breast tumor. The patient was a 76-year-old Japanese woman with a right breast mass. The mammography showed a 1.5-cm, lobulated high-density mass with partially ill-defined margins. Ultrasonography revealed an irregularly shaped mass with partially ill defined borders, hypoechoic and heterogeneous internal echoes, and posterior acoustic enhancement. These findings suggested an invasive carcinoma. Awareness of this type of tumor will help in correct diagnosis, in spite of the rarity of this disease.

Object shape dependency of in-plane resolution for iterative reconstruction of computed tomography

The present study aimed to investigate whether the in-plane resolution property of iterative reconstruction (IR) of computed tomography (CT) data is object shape-dependent by testing columnar shapes with diameters of 3, 7, and 10cm (circular edge method) and a cubic shape with 5-cm side lengths (linear edge method). For each shape, objects were constructed of acrylic (contrast in Hounsfield units [ΔHU]=120) as well as a soft tissue equivalent material (ΔHU=50). For each shape, we measured the modulation transfer functions (MTFs) of IR and filtered back projection (FBP) using two multi-slice CT scanners at scan doses of 5 and 10mGy. In addition, we evaluated a thin metal wire using the conventional method at 10mGy. For FBP images, the MTF results of the tested objects and the wire method showed substantial agreement, thus demonstrating the validity of our analysis technique. For IR images, the MTF results of different shapes were nearly identical for each object contrast and dose combination, and we did not observe shape-dependent effects of the resolution properties of either tested IR. We conclude that both the circular edge method and linear edge method are equally useful for evaluating the resolution properties of IRs.