Katsuhiro Kotake
Aichi Medical University
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Featured researches published by Katsuhiro Kotake.
Surgical Innovation | 2012
Tsuyoshi Kurokawa; Hiroshi Nagata; Takashi Arikawa; Akira Yasuda; Nobuhiro Ito; Katsuhiro Kotake; Toshiaki Nonami
Background. Owing to recent advances in laparoscopic surgery, devascularization of the upper stomach with splenectomy (Spx) or Hassab’s procedure (Has) as well as Spx for patients with portal hypertension have been attempted laparoscopically in some facilities, the results of which have been reported. This article describes the authors’ surgical techniques and their results. Methods. Between August 1999 and August 2010, the authors treated 110 cases of portal hypertension with Spx or Has. Among these patients, 56 who simultaneously underwent additional major operations were eliminated from the study, leaving 54 patients eligible. They included 38 with open surgeries and 16 with laparoscopic surgeries, which consisted of 10 splenectomies and 6 Has operations. The perioperative data for the 2 groups were compared. Results. Purely laparoscopic Spx (L-Spx) was completed for 9 patients. Conversion from laparoscopic to hand-assisted laparoscopic surgery (HALS) was necessary for 1 patient because of poor visualization. Operative time was significantly longer in L-Spx than in the open method. Postoperative hospital stays were shorter for L-Spx. HALS was used for all 6 laparoscopic Has patients. There was no conversion from the laparoscopic to the open method. Operative time was significantly longer for laparoscopic Has than for open Has. Postoperative complication rates were significantly reduced, and postoperative hospital stays were significantly shorter for laparoscopic Has. Conclusions. Although the data are still preliminary, laparoscopic surgery for patients with portal hypertension may prove to be a successful strategy.
World Journal of Surgical Oncology | 2011
Tsuyoshi Kurokawa; Yoshiharu Shimomura; Gustavo Bajotto; Katsuhiro Kotake; Takashi Arikawa; Nobuhiro Ito; Akira Yasuda; Hiroshi Nagata; Toshiaki Nonami; Kazuo Masuko
BackgroundPeroxisome proliferator-activated receptor α (PPARα) regulates lipid metabolism in the liver. It is unclear, however, how this receptor changes in liver cancer tissue. On the other hand, mouse carcinogenicity studies showed that PPARα is necessary for the development of liver cancer induced by peroxisome proliferators, and the relationship between PPARα and the development of liver cancer have been the focus of considerable attention. There have been no reports, however, demonstrating that PPARα is involved in the development of human liver cancer.MethodsThe subjects were 10 patients who underwent hepatectomy for hepatocellular carcinoma. We assessed the expression of PPARα mRNA in human hepatocellular carcinoma tissue and non-cancerous tissue, as well as the expression of target genes of PPARα, carnitine palmitoyltransferase 1A and cyclin D1 mRNAs. We also evaluated glyceraldehyde 3-phosphate dehydrogenase, a key enzyme in the glycolytic system.ResultsThe amounts of PPARα, carnitine palmitoyltransferase 1A and glyceraldehyde 3-phosphate dehydrogenase mRNA in cancerous sections were significantly increased compared to those in non-cancerous sections. The level of cyclin D1 mRNA tends to be higher in cancerous than non-cancerous sections. Although there was a significant correlation between the levels of PPARα mRNA and cyclin D1 mRNA in both sections, however the correlation was higher in cancerous sections.ConclusionThe present investigation indicated increased expression of PPARα mRNA and mRNAs for PPARα target genes in human hepatocellular carcinoma. These results might be associated with its carcinogenesis and characteristic features of energy production.
Hepatology Research | 2004
Yoshiharu Shimomura; Taro Murakami; Masaru Nagasaki; Takashi Honda; Hidemi Goto; Katsuhiro Kotake; Tsuyoshi Kurokawa; Toshiaki Nonami
Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 2000
Kiyoshi Ishigure; Yoshihisa Kawase; Kenji Ohshima; Katsuhiro Kotake; Hideki Kasuya; Kenrou Sawada; Toshiaki Nonami; Akio Harada; Akimasa Nakao
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2003
Katsuhiro Kotake; Tsuyoshi Kurokawa; Yoshihiro Ohwa; Hitoshi Inagaki; Mari Tsubamoto; Toshiaki Nonami
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2008
Katsuhiro Kotake; Hiroshi Nagata; Tsuyoshi Kurokawa; Masahiko Miyachi; Kazuyoshi Suzumura; Toshiaki Nonami
Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 2004
Nobuhiro Ito; Kazuyoshi Suzumura; Takashi Arikawa; Ichiro Horikoshi; Katsuhiro Kotake; Hitoshi Inagaki; Yosihiro Oowa; Hiroshi Nagata; Tsuyoshi Kurokawa; Toshiaki Nonami
Journal of pediatric surgery case reports | 2014
Shinsuke Katsuno; Minoru Horisawa; Hiroyuki Fujisaki; Takashi Arikawa; Katsuhiro Kotake; Tsuyoshi Kurokawa; Toshiaki Nonami
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2009
Katsuhiro Kotake; Hiroshi Nagata; Tsuyoshi Kurokawa; Masahiko Miyachi; Kazuyoshi Suzumura; Toshiaki Nonami; Emiko Takahashi; Kazuo Hara
Aichi Ika Daigaku Igakkai zasshi | 2005
Kazuyoshi Suzumura; Nobuhiro Ito; Hiroshi Nagata; Yoshihiro Oowa; Mari Tsubamoto; Ichirou Horikoshi; Takashi Arikawa; Katsuhiro Kotake; Toshiaki Nonami; Yoshihiro Fujikake; Kaoru Fujikake