Katsuhito Miyamoto
Chugai Pharmaceutical Co.
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Featured researches published by Katsuhito Miyamoto.
FEBS Letters | 1987
Junko Abe; Makiko Morikawa; Katsuhito Miyamoto; Shin-ichi Kaiho; Masafumi Fukushima; Chisato Miyaura; Etsuko Abe; Tatsuo Suda; Yasuho Nishii
Four analogues of vitamin D3 with an oxygen atom in the side chain skeleton were synthesized to determine whether their differentiation‐inducing activity could be separated structurally from their activity to induce hypercalcemia. The order of the in vitro potency to reduce nitroblue tetrazolium in human myeloid leukemia cells (HL‐60) was 22‐oxa‐1α25‐(OH)2D3 > 1α,25‐(OH)2D3 > 20‐oxa‐1α,25‐(OH)2D3≒22‐oxa‐1α‐(OH) D3 > 1α‐(OH)D3 > 20‐oxa‐1α‐(OH)D3. 22‐Oxa‐1α,25‐(OH)2D3, was also about 10‐times more potent than 1α,25‐(OH)2D3 in suppressing proliferation and inducing differentiation of mouse myelomonocytic leukemia cells (WEHI‐3), but the former was much weaker than the latter in inducing the release of 45Ca from prelabeled fetal mouse calvaria. These results suggest that the differentiation‐inducing activity of vitamin D compounds can be separated structurally from their activity to induce hypercalcemia.
Synthetic Communications | 1986
Katsuhito Miyamoto; Noboru Kubodera; Eigoro Murayama; Kiyoshige Ochi; Takashi Mori; Isao Matsunaga
Abstract The conversion of lithocholic acid (1) into 25-hydroxycholesterol (10) via methyl 3β-hydroxy-5-cholenate (6) is described.
Bioorganic & Medicinal Chemistry Letters | 1992
Eigoro Murayama; Katsuhito Miyamoto; Kiyoshige Ochi; Noboru Kubodera
Abstract The synthesis of Vitamin D analogues bearing pregnane side chains and their immunoregulating activity in mice are described.
Bioorganic & Medicinal Chemistry Letters | 1993
Noburo Kubodera; Hiroyoshi Watanabe; Katsuhito Miyamoto; Masahiko Matsumoto
Abstract The synthesis of four vitamin D3 analogues, 1α,24(S)- and 1α,24(R)-dihydroxy-22-oxa-vitamin D3, (5) and (6), and their 26,27-diemethylated homologues, (7) and (8), and the preliminary evaluation of their differentiation-inducing activity in vitro are described.
Steroids | 1992
Hiroyoshi Watanabe; Takehiko Kawanishi; Katsuhito Miyamoto; Noboru Kubodera; Kazuo Sasahara; Kiyoshige Ochi
Abstract A novel procedure for the preparation of 1α,3β-dihydroxy-2β-tritiated steroidal compounds by the reduction of the α-epoxide with sodium horotritiide in diglyme at 80 C is described.
Chemical & Pharmaceutical Bulletin | 1986
Eigoro Murayama; Katsuhito Miyamoto; Noboru Kubodera; Takashi Mori; Isao Matsunaga
Chemical & Pharmaceutical Bulletin | 1993
Katsuhito Miyamoto; Eigoro Murayama; Kiyoshige Ochi; Hiroyoshi Watanabe; Noboru Kubodera
Journal of Medicinal Chemistry | 1997
Hiroharu Matsuoka; Nobuhiro Ohi; Masahiko Mihara; Hiroshi Suzuki; Katsuhito Miyamoto; Noriaki Maruyama; Keiichiro Tsuji; Nobuaki Kato; Toshio Akimoto; Yasuhisa Takeda; Keiichi Yano; Toshio Kuroki
Archive | 1985
Katsuhito Miyamoto; Noboru Kubodera; Kiyoshige Ochi; Isao Matsunaga; Eigoro Murayama
Archive | 1985
Noboru Kubodera; Katsuhito Miyamoto; Kiyoshige Ochi; Isao Matsunaga; Eigoro Murayama