Katsumi Chiba

New synthesis of β-lactams

Abstract α-Methylene-β-lactams 3 were synthesized from the various 2-bromoallylamine derivatives 2 using a catalytic amount of Pd(OAc) 2 or PD(acac) 2 and PPh 3 , under 1–4 atom pressure of CO in good yields. Similarly, α-alkylidene-β-lactams 20 were synthesized from 3-alkyl-2-bromoallylamines 19 , which were easily prepared from the olefins 14 , in the same manner.

A novel synthesis of (±)-3-aminonocardicinic acid

(±)-3-Aminonocardicinic acid, which is an important starting material for the synthesis of nocardicin A and other biologically active analogues, has been synthesized by application of a new method for synthesis of α-methylene-β-lactams.