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Katsuya Ota

Nara Medical University

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Publication

Featured researches published by Katsuya Ota.

Journal of Virology | 2004

RNA Interference Directed against Poly(ADP-Ribose) Polymerase 1 Efficiently Suppresses Human Immunodeficiency Virus Type 1 Replication in Human Cells

Masanori Kameoka; Souichi Nukuzuma; Asako Itaya; Yasuharu Tanaka; Katsuya Ota; Kazuyoshi Ikuta; Koichiro Yoshihara

ABSTRACT We established small interfering RNA (siRNA) directed against poly(ADP-ribose) polymerase 1 (PARP-1) that effectively reduces the expression of PARP-1 in two human cell lines. Established siRNA against PARP-1 significantly suppressed human immunodeficiency virus type 1 (HIV-1) replication, as well as the activation of the integrated HIV-1 long terminal repeat promoter. These results indicate that PARP-1 is required for efficient HIV-1 replication in human cells. We propose that PARP-1 may serve as a cellular target for RNA interference-mediated gene silencing to inhibit HIV-1 replication.

The Journal of Neuroscience | 2001

Differential Expression of Apoptotic Protease-Activating Factor-1 and Caspase-3 Genes and Susceptibility to Apoptosis during Brain Development and after Traumatic Brain Injury

Alexander G. Yakovlev; Katsuya Ota; Geping Wang; Vilen A. Movsesyan; Wei-Li Bao; Koichiro Yoshihara; Alan I. Faden

Biochemical Journal | 2000

Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase.

Masanori Kameoka; Katsuya Ota; Toshifumi Tetsuka; Yasuharu Tanaka; Asako Itaya; Takashi Okamoto; Koichiro Yoshihara

Journal of Biochemistry | 2002

Alteration of Apoptotic Protease-Activating Factor-1 (APAF-1)-Dependent Apoptotic Pathway During Development of Rat Brain and Liver.

Katsuya Ota; Alexander G. Yakovlev; Asako Itaya; Masanori Kameoka; Yasuharu Tanaka; Koichiro Yoshihara

Biochemical and Biophysical Research Communications | 2005

Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cells.

Masanori Kameoka; Souichi Nukuzuma; Asako Itaya; Yasuharu Tanaka; Katsuya Ota; Yoshiaki Inada; Kazuyoshi Ikuta; Koichiro Yoshihara

Biochemical and Biophysical Research Communications | 2004

Regulation of HSF1-responsive gene expression by N-terminal truncated form of p73α

Yasuharu Tanaka; Masanori Kameoka; Asako Itaya; Katsuya Ota; Koichiro Yoshihara

Biochemical and Biophysical Research Communications | 1999

Poly (ADP-ribose) Polymerase Is Involved in PMA-induced Activation of HIV-1 in U1 Cells by Modulating the LTR Function☆

Masanori Kameoka; Yasuharu Tanaka; Katsuya Ota; Asako Itaya; Koichiro Yoshihara

Biochemical and Biophysical Research Communications | 2003

Expression of histone acetyltransferases was down-regulated in poly(ADP-ribose) polymerase-1-deficient murine cells.

Katsuya Ota; Masanori Kameoka; Yasuharu Tanaka; Asako Itaya; Koichiro Yoshihara

Experimental Cell Research | 2006

Up-regulation of NFκB-responsive gene expression by ΔNp73α in p53 null cells

Yasuharu Tanaka; Katsuya Ota; Masanori Kameoka; Asako Itaya; Koichiro Yoshihara

Experimental Cell Research | 1999

Establishment of persistent infection with HIV-1 abrogates the caspase-3-dependent apoptotic signaling pathway in U937 cells.

Yasuharu Tanaka; Masanori Kameoka; Katsuya Ota; Asako Itaya; Kazuyoshi Ikuta; Koichiro Yoshihara

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Koichiro Yoshihara

Nara Medical University

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Yasuharu Tanaka

Nara Medical University

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Masanori Kameoka

RMIT University

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Asako Itaya

Nara Medical University

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Kazuyoshi Ikuta

Osaka University

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Souichi Nukuzuma

Hokkaido University

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Alexander G. Yakovlev

Georgetown University

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Keizo Yamamoto

Nara Medical University

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Takashi Okamoto

Nagoya City University

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Takeshi Ide

Nara Medical University

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