Katumi Ikeda

Intralymphocytic free calcium and magnesium in stroke-prone spontaneously hypertensive rats and effects of blood pressure and various antihypertensive agents.

1. Free Ca2+ ([Ca2+]i) and Mg2+ ([Mg2+]i) were measured in peripheral lymphocytes from stroke‐prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar‐Kyoto rats (WKY) at the age of 5, 7 and 17 weeks, from various antihypertensive agents‐treated SHRSP, and from secondary hypertensive WKY.

FISH PROTEIN‐RICH DIET ATTENUATES HYPERTENSION INDUCED BY DIETARY Ng‐NITRO‐L‐ARGININE IN NORMOTENSIVE WISTAR‐KYOTO RATS

1. Dietary 0.023%NG‐nitro‐L‐arginine (L‐NNA), an inhibitor of nitric oxide synthesis, induced hypertension in normotensive Wistar‐Kyoto rats (WKY). This hypertension was significantly attenuated in WKY given a fish protein‐rich diet.

Antihypertensive Effect Of Cattle Bone Collagen-Derived Peptides In Ovariectomized Stroke-Prone Spontaneously Hypertensive Rats

1. The effect of food collagen, cattle bone collagen‐derived (CBC) peptides, on ovariectomy induced increases in blood pressure was examined in stroke‐prone spontaneously hypertensive rats (SHRSP).

ANALYSIS IN SPONTANEOUSLY HYPERTENSIVE RATS

1. Linkage analysis is performed between basal or salt‐ sensitive high blood pressure and several loci on chromosomes in F2 progenies obtained from crossing stroke‐prone spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto rats.

CHLORIDE ION INGESTED WITH SODIUM AFFECTS THE DEVELOPMENT OF CEREBRAL LESIONS IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

1. To determine the effect of chloride ion on the development of hypertension and the incidence of cerebral lesions in stroke‐prone spontaneously hypertensive rats (SHRSP), groups of 10 rats were administered chronically with either 171 mmol/L sodium chloride or equimolar sodium provided as sodium citrate in the drinking water from the age of 12 weeks.

Sodium preference and excretion in spontaneously hypertensive rats on various diets.

1. Stroke‐prone spontaneously hypertensive rats (SHRSP) and stroke‐resistant SHR (SHRSR) exhibited an increased preference for a 2% NaCl solution, relative to water, in comparison with normotensive Wistar‐Kyoto (WKY), but the preference was lost quickly in SHRSP with unbroken exposure.

HMG‐COA REDUCTASE INHIBITOR AFFECTS BLOOD PRESSURE AND VASCULAR REACTIVITY

1. To investigate the effect of endogenous cholesterol synthesis on blood pressure and vascular response, a HMG CoA reductase inhibitor, pravastatin (1 or 10 mg/kg) was administered orally for 2 or 4 weeks to 8–13 week old spontaneously hypertensive rats (SHR/Izm) and normotensive Wistar‐Kyoto (WKY/Izm) rats.