Kawashima Yoichi

Tabletting properties of bucillamine agglomerates prepared by the spherical crystallization technique

Abstract The tabletting properties of bucillamine agglomerates prepared by two spherical crystallization techniques, i.e., a spherically agglomeration method and an emulsion solvent diffusion method, were investigated. The flow and packing properties of agglomerates, represented in terms of the angle of repose and change in tapping density, were much improved by this technique compared with those of conventional crystals due to the spherical shape and smooth surface. Furthermore, spherical agglomerates possessed superior strength characteristics to conventional crystals, in particular, agglomerates obtained by the emulsion solvent diffusion method were compressed into compacts having considerable hardness without capping at high compaction pressure. The excellent compactibility of agglomerates was attributed to the fragmentation property and a greater degree of plastic deformation under compression.