Kay S. Arnold
University of California, Berkeley
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Metabolism-clinical and Experimental | 1984
Thomas L. Innerarity; Thomas P. Bersot; Kay S. Arnold; K H Weisgraber; Paul Davis; Trudy M. Forte; Robert W. Mahley
The receptor binding properties of lipoproteins derived from neonates and abetalipoproteinemic patients were examined. Compared to normal adults, the neonate plasma contained reduced cholesterol levels, with only 40% of the total cholesterol transported in the low-density lipoproteins (LDL). When compared at equal cholesterol concentrations, however, the total neonate lipoproteins (d less than 1.21) were as effective as adult d less than 1.21 lipoproteins in stimulating cholesteryl ester formation in cultured human fibroblasts. Analysis of the neonate lipoproteins explained their enhanced ability to deliver cholesterol to the cells via LDL (apoprotein B,E) receptors: the neonate d = 1.02-1.063 fraction contained, in addition to LDL, alpha 2-migrating, apoprotein E-rich high-density lipoproteins (HDL1), which were isolated by Geon-Pevikon electrophoresis. In binding studies performed with human fibroblasts at 4 degrees C, the neonate HDL1 were 14-fold more effective than either neonate or adult human LDL in displacing 125I-LDL from apo-B,E receptors. The neonate HDL (d = 1.063-1.21) contained a subfraction rich in apo-E and apo(E-A-II), which was isolated by heparin-Sepharose chromatography. This fraction was also active in displacing 125I-LDL from the receptors on cultured fibroblasts. Apoprotein E-containing HDL subclasses, similar to those described in the blood of neonates, were present in the d less than 1.063 and d = 1.063-1.21 lipoprotein fractions of patients with abetalipoproteinemia. These HDL with apo-E were enriched in cholesterol and were as effective as normal LDL in competing with 125I-LDL for apo-B,E receptor-mediated binding, internalization, and degradation. When incubated with cultured human fibroblasts, the HDL with apo-E from the abetalipoproteinemic subjects increased the cholesteryl ester mass three- to fourfold. These studies suggest that neonates and abetalipoproteinemic subjects may depend (at least in part) upon lipoproteins containing apo-E to deliver cholesterol to various tissues via the LDL (apo-B,E) receptor.
Proceedings of the National Academy of Sciences of the United States of America | 1979
Robert E. Pitas; Thomas L. Innerarity; Kay S. Arnold; Robert W. Mahley
Journal of Biological Chemistry | 1995
Richard Bucala; Robert F. Mitchell; Kay S. Arnold; Thomas L. Innerarity; Helen Vlassara; Anthony Cerami
Nature Structural & Molecular Biology | 1996
Li-Ming Dong; Sean Parkin; Sergei D. Trakhanov; Bernhard Rupp; Trey Simmons; Kay S. Arnold; Yvonne Newhouse; Thomas L. Innerarity; Karl H. Weisgraber
Journal of Lipid Research | 2000
Mohamed Zaiou; Kay S. Arnold; Yvonne Newhouse; Thomas L. Innerarity; Karl H. Weisgraber; Mark L. Segall; Michael C. Phillips; Sissel Lund-Katz
Nature | 1985
David R. Phillips; Kay S. Arnold; Thomas L. Innerarity
Arteriosclerosis, Thrombosis, and Vascular Biology | 1991
Walter Friedl; Erwin H. Ludwig; Maureen E. Balestra; Kay S. Arnold; Bemhard Paulweber; Friedrich Sandhofer; Brian J. McCarthy; Thomas L. Innerarity
Journal of Biological Chemistry | 1991
Sissel Lund-Katz; Thomas L. Innerarity; Kay S. Arnold; Linda K. Curtiss; Michael C. Phillips
Journal of Lipid Research | 1998
Li-Ming Dong; Thomas L. Innerarity; Kay S. Arnold; Yvonne Newhouse; Karl H. Weisgraber
Journal of Lipid Research | 1994
Kay S. Arnold; Maureen E. Balestra; Ronald M. Krauss; Linda K. Curtiss; Stephen G. Young; Thomas L. Innerarity