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Dive into the research topics where Kazuhiko Hamada is active.

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Featured researches published by Kazuhiko Hamada.


PLOS ONE | 2016

Efficient Percutaneous Delivery of the Antimelanogenic Agent Glabridin Using Cationic Amphiphilic Chitosan Micelles

Haruyoshi Seino; Yukari Arai; Norio Nagao; Noriyasu Ozawa; Kazuhiko Hamada

Partially myristoylated chitosan pyrrolidone carboxylate (PMCP) is a cationic amphiphilic chitosan derivative. Glabridin (Glab) from licorice root extracts is a hydrophobic antimelanogenic agent. Here we assessed the effects of cationic Glab-containing polymeric micelles derived from PMCP (Glab/PMCP-PM) on the ability of Glab to penetrate the skin and inhibit melanogenesis using a human skin model. The amount of Glab absorbed 24 h after the application of Glab/PMCP-PM was approximately four times higher than that of conventional oil-in-water micelles (control) prepared using Tween 60. Further, the release of IL-1α, a mediator of inflammation, was not detected. Treatment with Glab/PMCP-PM significantly increased the inhibition of melanogenesis compared with control. The inhibition of melanogenesis depends upon the enhanced ability of Glab to penetrate the skin, particularly the epidermis. Moreover, the inhibition of melanogenesis and the cationic potential of the Glab/PMCP-PM levels were increased by the cationic phospholipid copolymer. Therefore, Glab/PMCP-PM shows potential as an effective transdermal delivery system for treating skin hyperpigmentation.


Chemistry Letters | 1982

AN IMPROVED METHOD FOR THE CONVERSION OF SACCHARIDES INTO FURFURAL DERIVATIVES

Kazuhiko Hamada; Hiroshi Yoshihara; Gohfu Suzukamo


Archive | 1977

Process for producing a furan derivative

Kazuhiko Hamada; Gohu Suzukamo; Tsuneyuki Nagase


Archive | 1979

Process for the production of 4-hydroxybenzaldehyde derivatives

Kanji Nishizawa; Kazuhiko Hamada; Tadatoshi Aratani


Archive | 2002

ANTIINFLAMMATORY AGENT, PGE2 PRODUCTION INHIBITOR, IL-1alpha PRODUCTION INHIBITOR AND IL-6 PRODUCTION INHIBITOR

Akihiro Aioi; Kazuhiko Hamada; Kanji Ishimaru; Kiyomi Mizoguchi; Makoto Okuda; Hiroshi Tonogaito; Yasuhiro Yoshida; 康弘 吉田; 誠 奥田; 浩 殿垣内; 清美 溝口; 和彦 濱田; 章博 相生; 幹二 石丸


Archive | 2000

Hne-and-acrolein formation inhibiting and hne-and- acrolein decomposition promoting agent, and skin aging care preparation for external use

Kazuhiko Hamada; Kazutoshi Sakamoto; Takeshi Shigematsu; Takashi Takagi; Masako Tsutsumi; 雅子 堤; 和彦 濱田; 剛 重松; 和俊 阪本; 隆 高木


Bulletin of the Chemical Society of Japan | 1984

The dehydration of ketohexoses into 5-chloromethyl-2-furaldehyde: the isolation of diketohexose dianhydrides

Kazuhiko Hamada; Hiroshi Yoshihara; Gohfu Suzukamo; Osamu. Hiroaki


Archive | 1982

Process for producing 5-halomethylfurfural

Kazuhiko Hamada; Hiroshi Yoshihara; Gohfu Suzukamo


Archive | 1981

PROCESS FOR PRODUCING 5-METHYLFURFURAL

Kazuhiko Hamada; Goufu Suzukamo; Koichi Fujisawa


Journal of Oleo Science | 2001

Novel Synthetic Route to 2, 5-Disubstituted Furan Derivatives through Surface Active Agent-Catalysed Dehydration of D(-)-Fructose

Kazuhiko Hamada; Hiroshi Yoshihara; Gohfu Suzukamo

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