Kazuhiko Ishihara

CHAPTER 5:2-Methacryloyloxyethyl Phosphorylcholine Polymers

The synthesis and properties of phosphorylcholine group-bearing methacrylate, 2-methacryloyloxyethyl phosphorylcholine (MPC), and its polymers are described. Molecular design of the MPC polymers with significant functions for biomedical and medical applications is summarized in detail. Some MPC polymers have been provided commercially for these applications. The MPC polymer can provide an artificial cell membrane-like structure at the surface as an excellent interface between artificial systems and biological systems. The adsorption of proteins and adhesion of the cells are suppressed on the surface of the MPC polymers. In other words, the specific biomolecules immobilized on the MPC polymer surface show their original functions. In the clinical medicine field, MPC polymers have been used for surface modification of medical devices, including long-term implantable artificial organs to improve biocompatibility. The use of MPC polymers has increased worldwide as a result of their specific properties at the interface of artificial cell membrane-like structures.