Kazuhiko Moji

Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections

Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue haemorrhagic fever (DHF). To develop a better understanding of the roles of platelet‐associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue virus infection, the relationship between the PAIgG or PAIgM levels and disease severity as well as thrombocytopenia was examined in 78 patients with acute phase secondary infection in a prospective hospital‐based study. The decrease in platelet count during the acute phase recovered significantly during the convalescent phase. In contrast, the increased levels of PAIgG or PAIgM that occurred during the acute phase of these patients decreased significantly during the convalescent phase. An inverse correlation between platelet count and PAIgG or PAIgM levels was found in these patients. Anti‐dengue virus IgG and IgM activity was found in platelet eluates from 10 patients in an acute phase of secondary infection. Increased levels of PAIgG or PAIgM were significantly higher in DHF than those in dengue fever (DF). An increased level of PAIgM was associated independently with the development of DHF, representing a possible predictor of DHF with a high specificity. Our present data suggest that platelet‐associated immunoglobulins involving antidengue virus activity play a pivotal role in the induction of thrombocytopenia and the severity of the disease in secondary dengue virus infections.

Relationship between falls and physical performance measures among community-dwelling elderly women in Japan

Background and aims: The relationship between falls and physical performance has focused on the frail elderly who have several health problems, particularly those in nursing homes or care facilities. It is important to clarify the relationship between falls and physical performance among the community-dwelling elderly. Methods: We examined the relationship between falls and physical performance measures (grip strength, chair stand time, functional reach, usual walking speed) among 402 community-dwelling Japanese elderly women aged 60 years and over. Results: Overall prevalence of falls was 21.1%, and increased with age. In univariate analysis, grip strength and functional reach were not significantly different between women who did and did not fall. Chair stand time of women who fell was longer than that of women who did not (p=0.05), and the usual walking speed of women who fell was significantly slower than that of women who did not fall (p<0.0001). Physical functioning significantly decreased with age; grip strength, functional reach and usual walking speed decreased, and chair stand time increased. Logistic regression analysis, adjusting for age and other covariates, showed that slower usual walking speed was significantly associated with falls, but grip strength and functional reach were not. Increased chair stand time had a borderline association (p=0.1). Conclusions: Our findings indicate that poor lower extremity function, especially walking ability, is an important risk factor for falls in elderly Japanese community-dwelling women.

Decreased Serum Opsonic Activity against Streptococcus pneumoniae in Human Immunodeficiency Virus—Infected Ugandan Adults

Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community-acquired pneumonia and 58 asymptomatic Ugandan adults with or without human immunodeficiency virus type 1 (HIV-1) infection. The levels of serum IgG to CPS were significantly higher in HIV-1-infected subjects than in HIV-uninfected subjects. Serum samples from HIV-1-infected subjects that had lower IgG titers demonstrated higher opsonic activity against type 3 (titers of 7) and type 9 (titers of 7-11) pneumococcal strains. Plasma HIV-1 load also correlated inversely with serum opsonic activity against these strains, and peripheral blood CD4+ lymphocyte numbers also tended to correlate with serum opsonic activity in asymptomatic HIV-1-infected adults. Our findings suggest that the opsonic activity of type-specific IgG is impaired in the serum of HIV-1-infected African adults, which may expose them to a serious risk of invasive pneumococcal infections.

Chart analysis of body composition change among pre- and postadolescent Japanese subjects assessed by underwater weighing method.

OBJECTIVE: To examine the effect of age on the relationship between fat-free mass (FFM) and fat mass (FM), and fat-free mass index (FFMI) and fat mass index (FMI) by applying body composition chart analysis on pre- and postadolescent Japanese subjects.SUBJECTS AND METHOD: A sample of 516 children (244 boys and 272 girls) ranging in age from 11 to 17 y and 840 adults (288 male and 552 female subjects) ranging in age from 18 to 59 y were studied to determine a body composition by an underwater weighing method. FMI and FM were put on an x- and y-axis in body composition chart 1, and FFMI (FFM/ height2) and FMI (FM/height2) were taken on an x- and y-axis in body composition chart 2.RESULTS: In body composition chart 1, the plots for male subjects stayed flat from 11 to 14 y and after that a steady growth of FFM concurring with the FM growth was observed. During the adult stage, steady increments of FM and gradual decreases of FFM were observed. In body composition chart 2, steady increases of FFMI and gradual decreases of FMI were indicated in the male preadolescent period. In the adult stage, FFMI decreased year by year, although the FMI continued to increase. In female subjects, a conspicuous increase of FMI was observed throughout all periods of the present subjects. After middle age, the decline of FFMI was characteristically demonstrated in the chart.CONCLUSION: The relationships between FFM and FM are characteristically delineated on the body composition charts demonstrating clear gender differences. The change of body mass index was not reflecting the change of adiposity level in male subjects, although it was occurring along with the changes of the adiposity level in female subjects.

Dietary habit and selenium concentrations in erythrocyte and serum in a group of middle-aged and elderly japanese

Abstract We examined whether selenium (Se) levels in blood were related to dietary habits, age, sex, smoking, consumption of alcoholic beverages or obesity in a group of men and women above 40 years of age. Mean Se concentration in erythrocytes (ESe) was 244±50 (mean±SD) for males, and 235±36 ng/g for females; mean Se concentration in serum (SSe) was 111±19 for males, and 107±16 ng/ml for females. Multiple regression analysis revealed that the following variables were significant in determining ESe and SSe levels: fish consumption, age, and consumption of alcoholic beverages for ESe; and age, pattern of staple food consumption, and hemoglobin concentration in the blood for SSe.

Association of body mass index with joint pain among community-dwelling women in Japan

Background and aims: To investigate the impact of obesity on joint pain, we examined the association of body mass index (BMI) with joint pain. Methods: 351 community-dwelling Japanese women aged 40–85 years were asked about joint pain at specific joints, and height and weight were measured. Logistic regression analysis was used to evaluate BMI and other potential predictors of joint pain. Results: BMI was positively associated with knee pain, but not with pain at other specific pints, after adjusting for age. The association of BMI with knee pain remained significant after adjustment for an additional covariate (physical activity). We also examined the associations of age, BMI, and regular physical activity with joint pain at any site, in the arm, in the leg, or in the back. Independently of age and regular physical activity, BMI was positively associated with joint pain in the leg, but not with pain at any site, in the arm or in the back. No significant association of physical activity with joint pain at any site, in the arm, in the leg or in the back was found. Conclusions: Knee pain was associated with greater BMI. This finding supports previous longitudinal studies, suggesting that some knee pain could be prevented by avoidance of excess weight, if the association is causative. However, the association was not very strong; thus, it is likely that many cases of knee pain cannot be avoided by weight reduction only, and may require other interventions.

Comparison of body size and composition between young adult Japanese-Americans and Japanese nationals in the 1980s

Background : Data on body composition of American-born Japanese (Japanese-Americans) are scarce. Studies on differences of body composition between Japanese-Americans and Japanese nationals at various stages of life as well as at various times of measurements are useful for understanding the impact of lifestyle changes on body composition in the two societies. Aim : To see the differences in body size and composition between young adult Japanese-Americans and Japanese nationals. Subjects and Methods : Body size and composition of 50 Japanese-Americans consisting of 28 males and 22 females ranging in age from 18 to 23 years were compared with Japanese nationals matched for age and height. Body composition was measured using the underwater weighing method. The study was conducted in the 1980s in the USA and Japan. Results : The average percentage body fat of males was 13.7% for both Japanese-Americans and Japanese nationals, and that of females was approximately 24% for both groups, even though Japanese-American males and females had significantly greater body weight, fat-free mass, and body mass index than Japanese nationals. Conclusion : Although young adult Japanese-Americans showed larger body size than Japanese nationals, their percentage fat did not differ at this stage of life in the 1980s.