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Publication
Featured researches published by Kazuhiro Aihara.
Bioorganic & Medicinal Chemistry | 2003
Kazuhiro Aihara; Yuko Kano; Sohjiro Shiokawa; Toshiro Sasaki; Fumihito Setsu; Yumiko Sambongi; Miyuki Ishii; Kazuyo Tohyama; Takashi Ida; Atsushi Tamura; Kunio Atsumi; Katsuyoshi Iwamatsu
A series of 1beta-methylcarbapenems bearing an (imidazo[5,1-b]thiazolium-6-yl)methyl moiety, a 5,5-fused heterobicycle, at the C-2 position was synthesized and evaluated for in vitro antibacterial activities. CP0569 (1r) and its analogues showed potent antibacterial activities against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Gram-negative bacteria, including Pseudomonas aeruginosa. Moreover, CP0569 (1r) exhibited stronger antibacterial activity against MRSA and higher resistance to renal dehydropeptidase-1 (DHP-1) than any currently marketed carbapenems, that is, imipenem (IPM), panipenem (PAPM), and meropenem (MEPM).
Archive | 2001
Yuko Kano; Yasuo Yamamoto; Takahisa Maruyama; Takehiko Sawabe; Eiki Shitara; Kazuhiro Aihara; Kunio Atsumi; Takashi Ida
Archive | 2003
Takehiko Sawabe; Kazuhiro Aihara; Kunio Atsumi; Keiichi Ajito
Archive | 2001
Yuko Kano; Takahisa Maruyama; Yasuo Yamamoto; Eiki Shitara; Toshiro Sasaki; Kazuhiro Aihara; Kunio Atsumi; Katsuyoshi Iwamatsu; Takashi Ida
Archive | 1998
Yuko Kano; Kazuhiro Aihara; Yumiko Toyooka; Toshiro Sasaki; Hiromasa Takizawa; Kenichi Fushihara; Kazuko Kobayashi; Kunio Atsumi; Katsuyoshi Iwamatsu; Takashi Ida
Archive | 2001
Yuko Kano; Takahisa Maruyama; Yasuo Yamamoto; Eiki Shitara; Toshiro Sasaki; Kazuhiro Aihara; Kunio Atsumi; Katsuyoshi Iwamatsu; Takashi Ida
Archive | 1997
Kazuhiro Aihara; Toshiro Sasaki; Yumiko Toyooka; Yuko Kano; Kunio Atsumi; Katsuyoshi Iwamatsu; Takashi Ida
Archive | 1997
Kazuhiro Aihara; Toshiro Sasaki; Yumiko Toyooka; Yuko Kano; Kunio Atsumi; Katsuyoshi Iwamatsu; Takashi Ida
Archive | 2010
Takahisa Maruyama; Yuko Kano; Takashi Ando; Toshiro Sasaki; Kazuhiro Aihara; Toshiki Fujita
Archive | 2003
Yuko Kano; Takahisa Maruyama; Yumiko Sambongi; Kazuhiro Aihara; Kunio Atsumi; Kastuyoshi Iwamatsu; Takashi Ida
