Kazuhiro Ohkuda

Prognostic Value of Nucleolar Protein p120 in Patients With Resected Lung Adenocarcinoma

PURPOSE In this study we investigated the prognostic significance of proliferation-associated nucleolar protein p120 in primary resected lung adenocarcinoma because it reflects tumor growth fractions in vitro. PATIENTS AND METHODS Expression levels of p120 in tumors were assessed by immunohistochemistry in 74 patients who underwent radical resection. With clinical follow-up data, the prognostic significance of p120 calculated by labeling indices was evaluated using the Cox proportional hazards model. RESULTS p120 protein was clearly detected in nucleoli of adenocarcinoma cells. Its expression levels widely varied in each sample from 8.5% to 67. 2%, with a mean +/- SD of 35.2% +/- 15.1%. No significant correlation was found between expression levels of p120 and clinicopathologic factors. However, the expression levels of p120 were negatively correlated with the tumor doubling time calculated with retrospective chest roentgenograms. Using a cutoff value of 35% in the labeling index of p120, patients with high expression of p120 experienced early recurrence and shorter survival compared with those who had low expression of p120. Multivariate analysis showed that p120 served as an independent, as well as the strongest, prognostic factor for resected lung adenocarcinoma. CONCLUSION This report provides the first evidence that expression levels of p120 in tumor tissues can be used as an independent and powerful prognostic marker for resected lung adenocarcinoma.

Beta-adrenergic blocking effect of dichloroisoprenaline (DCI), (H 56/28, I.C.I. 50172, LB 46), methoxamine (MJ 1999) and propranolol on the sinus node activity of the dog heart

Der Hemmungseffekt siebenΒ-adrenergischer Blockierungsmittel auf positive chronotrope Wirkung bei zunehmender Dosierung von Isoprenalin wurde durch Verabreichung in die Sinusknotenarterie vergleichend untersucht. Reihenfolge der Wirksamkeit: LB 46, H 56/28, Propranolol>I.C.I. 50172, DCI>MJ 1999>Methoxamin.

Effects of catecholamines on the AV nodal pacemaker in situ after destroying the SA node

Abstract Perfusion of the AV node artery in 15 dogs was performed in situ. After destroying the SA node by selective injection of ethanol into the sinus node artery, administration of catecholamines (dopamine, norepinephrine, epinephrine and isoproterenol) into the sinus node artery produced an acceleration of AV nodal rhythm. During the course of recovery, a sudden deceleration or oscillatory change in the AV nodal rhythm was usually observed. This change was not influenced by treatment with atropine, tetrodotoxin or phenoxybenzamine, while both the acceleration and the postaccelerator change were completely blocked by propranolol. These results suggest that postaccelerator changes, i.e., deceleration or oscillation of the AV nodal rhythm, are characteristics of the AV nodal pacemaker itself.

A Case of Mucoepidermoid Carcinoma of the Subsegmental Bronchus.

症例は75歳, 女性. 住民検診にて胸部異常陰影を指摘され, 精査目的に当科に入院となった. 気管支鏡検査にてlB1+2a亜区域支内に内腔をほぼ完全閉塞する複数のポリープ状腫瘍が認められた. 生検組織診では腺腫が疑われた. 胸部X線写真およびCTにて腫瘍閉塞部より末梢肺は軽度の閉塞性肺炎像を呈していた. 確定診断および肺炎増悪を防ぐ目的にて開胸, 左下区々域切除を施行した. 腫瘍はlB1+2a亜区域～亜々区域支にかけた気管支内腔に発育し, 壁外浸潤は認められなかった. 迅速診断にて低悪性度の粘表皮癌と診断された. 術後1年健在である. 粘表皮癌は術前診断に難渋を来す疾患である.