Kazuma Tsuruta

Pseudohyperaldosteronism (riddle’s Syndrome): A Case Report

AbstractA 22-year-old man was hospitalized because of hypertension, hypokalemic alkalosis and suppressed plasma renin activity. Although these findings were similar to hyperaldosteronism, plasma aldosterone concentration and urinary aldosterone excretion were lower than the normal range. Adrenocortical function also was normal except for aldosterone. Treatment with spironolactone, salt restriction and potassium supplementation improved the hypokalemia but not the hypertension. Blood pressure decreased markedly after administration of triamterene.

Aldosterone-producing gigantic adrenocortical adenoma with calcifications and cysts

Abstract We report on an aldosterone-producing gigantic adrenocortical adenoma with calcifications and cysts, which we believe is rare.

Intrarenal Prostaglandins: Effect of Sodium and Indomethacin on PGE2 and PGF2α in Rabbits

The levels of prostaglandins (PGS) E2 and F2α in different parts of the rabbit kidney were determined to observe the effect of sodium and indomethacin. After the pretreatment with injections of saline or with indomethacin, tissues from inner and outer medulla and cortex were separated, extracted, analyzed for PGE2 and PGF2α by radioimmunoassay. In the normal rabbit kidney, the greatest amount of PG was found in the inner medulla. Saline injections appeared to increase PGE2 (but not PGF2α), especially in the inner medulla. Repeated injections of saline, on the other hand, markedly reduced PGE2 in the inner medulla but increased outer medullary PGE2. Indomethacin reduced the production of PGS in all kidney segments. These results suggest the bidirectional effect of sodium on PG concentration in the rabbit kidney. Acute administration of sodium may directly stimulate the synthesis of PGE2 in the inner medulla but chronic stimulation with sodium may alter the pattern of PGE2 synthesis.

Studies on Intrarenal Prostaglandins

The unilateral renal artery in rabbits was constricted, and lipid droplet count in the medullary interstitial cells of the ‘opposite’ kidney was performed 1 week after surgery. Lipid droplet count in

Intrarenal Prostaglandins E2 and F2α in Experimental Renovascular Hypertension

To study the role of renal prostaglandins (PGs) in renovascular hypertension, PGE2 and PGF2α concentrations in both inner and outer medullae of the kidney were measure