Kazumasa Akikawa

The Significance of the Measurement of Plasma Transferrin as a Growth Factor

The concentrations of plasma transferrin (Tf), which has been described as possessing growth promoting activity in vitro, were determined in patients with various endocrine diseases before and after treatment. Plasma Tf levels in 74 healthy subjects were 269 +/- 3 (mean +/- SE) mg/dl. In 11 patients with active acromegaly, they were elevated to 353 +/- 11 mg/dl (p less than 0.001), while they were reduced to 168 +/- 14 mg/dl in 8 patients with hypopituitarism (p less than 0.001). They were normalized after treatment. These data indicate that plasma Tf varies according to the endocrine conditions with good correlation of the status of plasma somatomedin C, and therefore its measurement may be useful clinically for the evaluation of the status of growth factors. However, the values should be assessed carefully in cases with proper Tf abnormalities, such as hematological, hepatic, or renal disorders.