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Dive into the research topics where Kazumasa Goda is active.

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Featured researches published by Kazumasa Goda.


International Journal of Urology | 2006

Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University.

Nobuyuki Hinata; Toshiro Shirakawa; Shuji Terao; Kazumasa Goda; Kazushi Tanaka; Yuji Yamada; Isao Hara; Sadao Kamidono; Masato Fujisawa; Akinobu Gotoh

Abstract  There is no effective therapy for hormone‐refractory prostate cancer and a novel therapeutic modality, such as a gene therapy, should be actively pursued. Previously, Gardner and Chung conducted a phase I clinical trial of Ad‐OC‐TK (recombinant adenoviral vector containing osteocalcin promoter‐driven herpes simplex virus thymidine kinase gene) plus VAL (valacyclovir) for the treatment of hormone‐refractory prostate cancer at the University of Virginia. We report on our ongoing phase I/II clinical trial of Ad‐OC‐TK plus VAL for the treatment of advanced prostate cancer at the Kobe University Hospital, Japan.


Journal of Gene Medicine | 2004

Adenoviral-mediated HGF expression inhibits germ cell apoptosis in rats with cryptorchidism.

Kazumasa Goda; Masato Fujisawa; Toshiro Shirakawa; Masaki Dobashi; Goshi Shiota; Zhu Jun Zhang; Akinobu Gotoh; Sadao Kamidono

Prior studies have shown that the hepatocyte growth factor (HGF), as known for its multiple biological effects, possibly regulates spermatogenesis or tubulogenesis in the testis. To clarify the effect of HGF on restoration of spermatogenesis, or testicular weight, we transferred the HGF gene into the testis of the rat experimental cryptorchid model.


International Journal of Urology | 2004

Cut‐to‐the‐light technique and potassium titanyl phosphate laser ureterotomy for complete ureteral obstruction

Kazumasa Goda; Gaku Kawabata; Tomihiko Yasufuku; Isao Hara; Masato Fujisawa; Sadao Kamidono; Hiroshi Okada

We describe a case of complete ureteral obstruction managed by endoscopic recanalization using a ‘cut‐to‐the‐light’ technique followed by potassium titanyl phosphate (KTP) laser ureterotomy. A 53‐year‐old man developed a ureteral obstruction following the transurethral resection of a bladder tumor (TUR‐Bt) at the left ureteral orifice. The length of the obstructed segment was estimated at 1 cm based on combined antegrade and retrograde contrast studies. Histopathological analysis indicated that the obstruction was caused by fibrosis. The ‘cut‐to‐the‐light’ technique was used for recanalization, and KTP laser ureterotomy was performed to obtain an adequate ureteral lumen. A 14 F/7 F endoureterotomy stent was removed 6 weeks after the operation. No significant complications and no signs of stenosis were observed 24 months after endoscopic repair. Endoscopic recanalization is a safe, effective technique for the management of a completely obliterated ureteral segment, especially in combination with subsequent KTP laser ureterotomy.


Fertility and Sterility | 2005

Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter’s syndrome

Hiroshi Okada; Kazumasa Goda; Yasuhisa Yamamoto; Nikolaos Sofikitis; Ikuo Miyagawa; Yasuyuki Mio; Mitsunobu Koshida; Shigeo Horie


Journal of Andrology | 2005

Overexpression of Endothelial Nitric Oxide Synthase in Transgenic Mice Accelerates Testicular Germ Cell Apoptosis Induced by Experimental Cryptorchidism

Tomomoto Ishikawa; Yutaka Kondo; Kazumasa Goda; Masato Fujisawa


Fertility and Sterility | 2005

Four pregnancies in nonmosaic Klinefelter’s syndrome using cryopreserved-thawed testicular spermatozoa

Hiroshi Okada; Kazumasa Goda; Satoru Muto; Osamu Maruyama; Mitsunobu Koshida; Shigeo Horie


Fertility and Sterility | 2004

Serum testosterone levels in patients with nonmosaic Klinefelter syndrome after testicular sperm extraction for intracytoplasmic sperm injection.

Hiroshi Okada; Toshiro Shirakawa; Tomomoto Ishikawa; Kazumasa Goda; Masato Fujisawa; Sadao Kamidono


Urology | 2007

Midkine promoter-based conditionally replicative adenovirus for targeting midkine-expressing human bladder cancer model.

Shuji Terao; Toshiro Shirakawa; Shuji Kubo; Acharya Bishunu; Sang-Jin Lee; Kazumasa Goda; Mamoru Tsukuda; Katsuyuki Hamada; Masatoshi Tagawa; Atsushi Takenaka; Masato Fujisawa; Akinobu Gotoh


Anticancer Research | 2005

Recombinant Interleukin-2 Enhanced the Antitumor Effect of ADV/RSV-HSV-tk/ACV Therapy in a Murine Bladder Cancer Model

Shuji Terao; Toshiro Shirakawa; Kazumasa Goda; Sadao Kamidono; Masato Fujisawa; Akinobu Gotoh


Asian Journal of Andrology | 2005

Erythropoietin gene transfer into rat testes by in vivo electroporation may reduce the risk of germ cell loss caused by cryptorchidism

Masaki Dobashi; Kazumasa Goda; Hiroki Maruyama; Masato Fujisawa

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Akinobu Gotoh

Hyogo College of Medicine

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Hiroshi Okada

Dokkyo Medical University

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Shuji Terao

Hyogo College of Medicine

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Isao Hara

Wakayama Medical University

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