Kazunari Mado
Nihon University
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Publication
Featured researches published by Kazunari Mado.
Journal of The American College of Surgeons | 2013
Takero Mazaki; Kazunari Mado; Hideki Masuda; Motomi Shiono
BACKGROUND Efficacy of antibiotic prophylaxis for the prevention of surgical site infection (SSI) after open tension-free hernia repair remains controversial. In light of additional data, the aim of this study was to determine whether antibiotic prophylaxis reduces SSI after hernia repair. STUDY DESIGN We conducted a systematic review and meta-analysis to identify randomized controlled trials comparing antibiotic prophylaxis and the subsequent incidence of SSI after inguinal or femoral hernia repair. The primary outcomes measure was the incidence of SSI. Subgroup analysis was evaluated by stratifying the categories of SSI. The meta-analysis was performed using Bayesian and frequentist methods. RESULTS Twelve studies were included in this meta-analysis; 1,902 patients received antibiotic prophylaxis and the other 1,936 patients were allocated to the control group. Incidence of SSI was 47 (pooled rate 3.0%) in the antibiotic group and 91 (6.0%) in the control group. The number needed to treat to prevent 1 episode of SSI is 41. The Bayesian meta-analysis yielded a significant reduction of SSI in the antibiotic group (odds ratio = 0.49; 95% credible interval 0.25-0.81). Subgroup analysis showed that an antibiotic prophylaxis was beneficial for the prevention of superficial SSI (odds ratio = 0.40; 95% credible interval 0.12-0.98), but not beneficial for prevention of deep SSI (odds ratio = 0.59; 95% credible interval 0.11-3.20). Also, the results were similar to those with frequentist methods. CONCLUSIONS This meta-analysis suggests that antibiotic prophylaxis is efficacious for the prevention of SSI after open mesh hernia repair.
American Journal of Surgery | 2014
Takero Mazaki; Kazunari Mado; Hideki Masuda; Motomi Shiono; Noahiro Tochikura; Morio Kaburagi
BACKGROUND The efficacy of antibiotic prophylaxis for the prevention of surgical-site infection (SSI) after open tension-free inguinal hernia repair remains controversial. METHODS A double-blind, randomized, placebo-controlled trial was conducted. Patients who underwent elective open mesh-plug hernia repair were eligible for randomization. In the antibiotic prophylaxis group, 1.0 g cefazolin was intravenously administrated 30 minutes before the incision. In the placebo group, an equal volume of sterile saline was administered. The primary end point was the incidence of SSI. RESULTS A total of 200 patients were enrolled. SSI developed in 2 of 100 patients (2%) in the antibiotic prophylaxis group and 13 of 100 patients (13%) in the placebo group, indicating a significant difference between the 2 groups (relative risk ratio, 0.25; 95% confidence interval, 0.070 to 0.92; P = .003). Other complications occurred in 23 patients: 7 (7%) in the antibiotic prophylaxis group and 16 (16%) in the placebo group (P = .046). CONCLUSIONS This study indicates that antibiotic prophylaxis is effective for the prevention of SSI after open mesh-plug hernia repair.
World Journal of Surgical Oncology | 2006
Kazunari Mado; Yukimoto Ishii; Takero Mazaki; Masaya Ushio; Hideki Masuda; Tadatoshi Takayama
BackgroundAn oral combined fluoropyrimidine anticancer drug, tegafur/gimeracil/oteracil potassium (S-1), has recently been used alone or in combination for colon cancer.Case presentationThe patient was a 42-year-old man with sigmoid colon cancer with direct invasion of the urinary bladder and multiple costal metastases. A diagnosis of T4, M1, stage IV sigmoid colon cancer was made, and curative resection was considered impossible. S-1 at 50 mg/m2 was administered by oral route from day 1 to day 14. Irinotecan (CPT-11) at 40 mg/m2 was administered by intravenous day 1 and 15. This treatment was followed by 2 weeks absent period, and repeated every 4 weeks. Six cycles of administration were performed in total. Following this treatment, the multiple costal metastases resolved. Down-staging to T3, M0, stage IIA was achieved, and curative resection was judged to be possible.ConclusionOccasional cases in which S-1/CPT-11 therapy was effective have been recently reported. The patients tumor became resectable despite the discovery of colon cancer associated with bone metastasis at the initial examination, offering hope for cancer patients.
Journal of Gastroenterology | 2014
Takero Mazaki; Kazunari Mado; Hideki Masuda; Motomi Shiono
Surgery | 2008
Tatsuya Tomizuka; Takero Mazaki; Kazunari Mado; Akihiro Henmi; Yukimoto Ishii; Hideki Masuda; Tadatoshi Takayama
The Japanese Journal of Gastroenterological Surgery | 2009
Kazunari Mado; Hideki Masuda; Takero Mazaki; Yukimoto Ishii; Nobuhiko Aoki; Hirohisa Ogame; Jun Manmoto; Nao Yoshida; Tadatoshi Takayama
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2009
Kazunari Mado; Hideki Masuda; Takero Mazaki; Yukimoto Ishii; Nobuhiko Aoki; Akihiro Hemmi
Nihon Gekakei Rengo Gakkaishi (journal of Japanese College of Surgeons) | 2013
Yusuke Mitsuka; Tadatoshi Takayama; Nobuyuki Kubota; Shintaro Yamazaki; Riki Okubo; Kazunari Mado; Daijyo Jinno; Makio Kobayashi
Journal of Nihon University Medical Association | 2012
Kazunari Mado; Nobuyuki Kubota; Yasuhiko Nakata; Daijo Jinno; Tadatoshi Takayama
Journal of Medicine | 2012
Kazunari Mado; Nobuyuki Kubota; Yasuhiko Nakata; Daijo Jinno; Tadatoshi Takayama