Kazunori Furugori
Nagoya University
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Featured researches published by Kazunori Furugori.
Iubmb Life | 1997
Shigehiko Morikawa; O. Kurauchi; Masashi Tanaka; Makoto Yoneda; Koji Uchida; Atsuo Itakura; Kazunori Furugori; Shigehiko Mizutani; Yutaka Tomoda
Lipid peroxides and their related free radicals have been implicated in the pathogenesis of placental dysfunction in preeclampsia. Recent studies suggest that the placenta is a source of the increased lipid peroxides in the maternal circulation of women with preeclampsia. We examined intracellular localization of 4‐hydroxy‐2‐nonenal (HNE: a major aldehydic product of lipid peroxidation)‐modified proteins in human placentas by immunohistochemistry, and immunoblotting. The trophoblast layer of the chorionic villi showed intense immunoreactivity for HNE‐modified proteins in 4 of 12 preeclamptic placentas, whereas no staining was observed in 12 normal placentas. Immunoblotting revealed that three immunoreactive proteins with apparent molecular mass of 110 kDa, 75 kDa, and 70 kDa were localized in the mitochondrial fraction. The present results indicate that the damage to mitochondrial proteins by lipid peroxidation byproducts and subsequent dysfunction of trophoblasts contribute to the pathophysiology of preeclampsia.
Reproductive Medicine and Biology | 2003
Kazunori Furugori; Hisao Ando; Tomomi Ito; Shigehiko Mizutani
The mechanism of monozygotic multifetal pregnancy and its association with assisted reproductive technology are uncertain. This report presents two cases of dizygotic triplet pregnancy after the transfer of three embryosin utero. The incidence of monozygotic twinning following assisted conception procedures is higher than in the general population. Zonal manipulation may be a major factor in the increased incidence of monozygotic twinning. As both cases followed the conventionalin vitro fertilization (IVF), the reason for these monozygotic twinnings might be because of the changes in the zona pellucida inin vitro conditions. In one case, fetuses developed into severe twin-to-twin transfusion syndrome (UTS), resulting in one intrauterine fetal death at 26 weeks gestation.
The Journal of Clinical Endocrinology and Metabolism | 1997
Kazunori Furugori; O. Kurauchi; Atsuo Itakura; Yasuhiko Kanou; Yoshiharu Murata; Shigehiko Mizutani; Hisao Seo; Yutaka Tomoda; Toshikazu Nakamura
Molecular Human Reproduction | 2006
Yuji Shimomura; Hisao Ando; Kazunori Furugori; Hiroaki Kajiyama; Miyabi Suzuki; Akira Iwase; Shigehiko Mizutani; Fumitaka Kikkawa
Human Reproduction | 2003
Hisao Ando; Kazunori Furugori; Daijiro Shibata; Toko Harata; Yasutaka Murata; Shigehiko Mizutani
Biochemical and Biophysical Research Communications | 1997
Atsuo Itakura; O. Kurauchi; Shigehiko Morikawa; Makoto Okamura; Kazunori Furugori; Shigehiko Mizutani
Obstetrics & Gynecology | 1997
Atsuo Itakura; O. Kurauchi; Shigehiko Morikawa; Kazunori Furugori; Shigehiko Mizutani; Yutaka Tomoda
Placenta | 1994
O. Kurauchi; T. Furui; Kazunori Furugori; N. Kuno; Shigehiko Morikawa; Atsuo Itakura; Shigehiko Mizutani; Yutaka Tomoda
Journal of Japan Society for the Study of Toxemia of Pregnancy | 1996
Shigehiko Morikawa; O. Kurauchi; Kazunori Furugori; Naohiko Kuno; Atsuo Itakura; Shigehiko Mizutani; Yutaka Tomoda
Placenta | 1995
Atsuo Itakura; O. Kurauchi; Tomomitsi Okamoto; Shigehiko Morikawa; Kazunori Furugori; Shigehiko Mizutani; Yutaa Tomoda