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Dive into the research topics where Kazuo Shinya is active.

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Featured researches published by Kazuo Shinya.


Journal of Organic Chemistry | 2015

Total Synthesis and Structure Determination of JBIR-108—A 2-Hydroxy-2-(1-hydroxyethyl)-2,3-dihydro-3(2H)-furanone Isolated from Streptomyces gramineus IR087Pi-4

Koichi Fujiwara; Hirokazu Tsukamoto; Miho Izumikawa; Takahiro Hosoya; Motoki Takagi; Hideki Yamamura; Masayuki Hayakawa; Kazuo Shinya; Takayuki Doi

The planar and stereostructures of JBIR-108 isolated from Streptomyces gramineus IR087Pi-4 were determined partly by spectral analysis, and these structural assignments were confirmed and completed by the total synthesis of both 1-epimers. The key stereocenters in JBIR-108 were constructed via a Corey-Bakshi-Shibata (CBS) reduction (C-1), vinylogous Mukaiyama aldol reaction (C-7), and Brown crotylation (C-14 and C-15). Although it was difficult to determine the stereochemistries at the C-1 and C-7 positions in the natural product using the modified Moshers method, the synthesis of two possible C-1 diastereomers enabled the identification of the configurations at the hitherto unknown stereocenters.


Archive | 2005

Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance

Kazuo Shinya; Tohru Natsume; Takayuki Doi


Archive | 2005

Labeling Substance and Chimera Substance, Process for Preparing These Substances, and Method of Biosubstance Trapping, Structural Analysis or/and Identification with Use of the Labeling Substance

Kazuo Shinya; Tohru Natsume; Takayuki Doi


日本生物工学会大会講演要旨集 | 2015

3P-261 Functional analysis of the antibiotic BD-12 biosynthetic genes

Haruka Niikura; Chitose Maruyama; Miho Izumikawa; Jun Ishikawa; Haruo Ikeda; Kazuo Shinya; Yoshimitsu Hamano


Archive | 2012

Promoter activity enhancer

Isshin Tanaka; 田中 一新; Kazuo Shinya; 一男 新家; Motoki Takagi; 基樹 高木


International Symposium on the Chemistry of Natural Products | 2006

P-286 Total Synthesis of Spiruchostatin A

Yusuke Iijima; Takayuki Doi; A. Ganesan; Kazuo Shinya; Takashi Takahashi


International Symposium on the Chemistry of Natural Products | 2006

P-255 TOTAL SYNTHESIS OF TELOMESTATIN

Takayuki Doi; Masahito Yoshida; Kazuo Shinya; Takashi Takahashi


Archive | 2005

A method for biosubstanzeinfang, for analyzing the structure and / or identification using a labeling substance

Kazuo Shinya; Tohru Natsume; Takayuki Doi


Archive | 2005

Markierungssubstanz undchimärensubstanz, verfahren zur herstellung dieser substanzen sowie verfahrenzum biosubstanzeinfang, zur strukturanalyse oder/und identifizierung unter verwendungder markierungssubstanz

Kazuo Shinya; Tohru Natsume; Takayuki Doi


Archive | 2005

Verfahren zum biosubstanzeinfang, zur strukturanalyse oder/und identifizierung unter verwendung einer markierungssubstanz Method for biosubstanzeinfang, for structural analysis and / or identification using a marker substance

Kazuo Shinya; Tohru Natsume; Takayuki Doi

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Tohru Natsume

National Institute of Advanced Industrial Science and Technology

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Takashi Takahashi

Yokohama College of Pharmacy

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Chitose Maruyama

Fukui Prefectural University

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Haruka Niikura

Fukui Prefectural University

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