Kee-Don Park

Growth hormone-releasing peptide-biotin conjugate stimulates myocytes differentiation through insulin-like growth factor-1 and collagen type I

Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 on muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested on cultured myoblast cells. Increased expression of myogenic marker proteins was observed in GHRP-6-biotin conjugate-treated cells. Additionally, increased expression levels of insulin-like growth factor-1 and collagen type I were observed. Furthermore, GHRP-6-biotin conjugate-treated cells showed increased metabolic activity, as indicated by increased concentrations of energy metabolites, such as ATP and lactate, and increased enzymatic activity of lactate dehydrogenase and creatine kinase. Finally, binding protein analysis suggested few candidate proteins, including desmin, actin, and zinc finger protein 691 as potential targets for GHRP6-biotin conjugate action. These results suggest that the newly synthesized GHRP-6-biotin conjugate has myogenic stimulating activity through, at least in part, by stimulating collagen type I synthesis and several key proteins. Practical applications of the GHRP-6-biotin conjugate could include improving muscle condition. [BMB Reports 2015; 48(9): 501-506]

Antiaging and antioxidant effects of topical autophagy activator: A randomized, placebo‐controlled, double‐blinded study

Recently, potential roles of autophagy in skin homeostasis received many interests. But, little has been reported for the potential antiaging effects of autophagy activator.

Micronutrients in Skin Immunity and Associated Diseases

Abstract The skin is the first line of defense for protecting internal tissues against external perturbations, such as physical/chemical stressors, UV irradiation, and pathogenic microorganisms. Of the many factors that impact overall skin integrity, nutritional status plays a crucial role in modulating the action of cutaneous immune responses. In particular, a deficiency in certain micronutrients can cause impairment of innate and adaptive immunity, leading to increased susceptibility to infection and diseases of the skin. Here, we describe the influences of select micronutrients on the immune system, and discuss their significance in certain skin diseases.