Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Kei Mukai is active.

Publication


Featured researches published by Kei Mukai.


Journal of Pharmaceutical Sciences | 2016

Application of Three-Dimensionally Printed Probe and Reservoir to Critical Micelle Concentration Determination by Microvolume Surface Tension Measurement

Shohei Horiuchi; Naoki Choda; Haruyuki Takahashi; Tomomi Sato; Hikaru Taira; Kei Mukai

It is important to determine a critical micelle concentration (CMC) of a surfactant in a protein formulation for stabilizing the protein at maximum by preventing it from interfacial denaturation. There are several techniques for CMC determination. Among them, surface tensiometry is the most common approach because this has a long history and much data at many research fields. However, large amount of sample solution is usually required for the measurement (e.g., more than 1 mL is necessary when a standard reservoir like a glass petri dish is used). This is one of the hurdles for protein formulators because only a small amount of protein could be used at the early-stage development. In this research, we tried to minimize the required amount of sample solution for surface tension measurement by developing appropriate probe and reservoir using a three-dimensional printer (3D printer). The advantages and capabilities of 3D printer are (1) to control the shape and size of the printed material precisely, (2) to change the figure freely, and (3) to prepare the prototype quickly. After the experiments and thereby the refinement of probe as well as reservoir, we found that CMCs of polysorbate 20, polysorbate 80, and poloxamer 188 in water and protein formulations could be precisely detected using a probe 0.5 mm in diameter and small reservoir with a pocket of 7.5 mm in diameter/0.25 mm in depth which were made by a 3D printer. Furthermore, the required sample solution per each measurement could be reduced to 80 μL, which means more than 90% reduction against a standard reservoir.


Archive | 2005

Sustained-release composition, process for producing the same and use of the same

Tomomichi Futo; Kei Mukai; Jiichi Arai


Archive | 2001

MANUFACTURING METHOD FOR FREEZE-DRIED PRODUCT

Kei Mukai; Muneo Nonomura; 圭 向井; 宗夫 野々村


Archive | 1999

Lyophilization method for sustained-release preparations

Hisayoshi Shimizu; Muneo Nonomura; Tomomichi Futo; Kei Mukai


Archive | 2004

Production method for sustained-release preparation

Hisayoshi Shimizu; Muneo Nonomura; Tomomichi Futo; Kei Mukai


Archive | 2001

Production method for freeze-dried products

Muneo Nonomura; Kei Mukai


Archive | 2016

Pharmaceutics, Drug Delivery and Pharmaceutical Technology Application of Three-Dimensionally Printed Probe and Reservoir to Critical Micelle Concentration Determination by Microvolume Surface Tension Measurement

Shohei Horiuchi; Naoki Choda; Haruyuki Takahashi; Tomomi Sato; Hikaru Taira; Kei Mukai


Archive | 2010

Producing a sustained-release preparation

Hisayoshi Shimizu; Muneo Nonomura; Tomomichi Futo; Kei Mukai


Archive | 2005

Composición de liberación sostenida, procedimiento para su producción y uso de la misma

Tomomichi Futo; Kei Mukai; Jiichi Arai


Archive | 1999

Verfahren zur gerfriertrocknung von präparaten mit verzörgerter wirkstoffabgabe

Hisayoshi Shimizu; Muneo Nonomura; Tomomichi Futo; Kei Mukai

Collaboration


Dive into the Kei Mukai's collaboration.

Top Co-Authors

Avatar

Muneo Nonomura

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Tomomichi Futo

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Hisayoshi Shimizu

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Haruyuki Takahashi

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Hikaru Taira

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Naoki Choda

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Shohei Horiuchi

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar

Tomomi Sato

Takeda Pharmaceutical Company

View shared research outputs
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge