Keiji Terao
Tokyo University of Agriculture and Technology
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Publication
Featured researches published by Keiji Terao.
Biomedical Research and Clinical Practice | 2017
Yukiko Uekaji; Keiji Terao
Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like, benzoquinone compound that functions primarily as an antioxidant, as a membrane stabilizer and as a cofactor in the oxidative phosphorylation production of adenosine triphosphate (ATP) . The solubility of CoQ10 in water is extremely low, resulting in a low bioavailability by oral administration. Therefore, we attempted to improve the low dissolution and bioavailability of CoQ10 by means of complexation with various cyclodextrins. We found that the bioavailability of CoQ10 could be significantly enhanced by complexation with cyclodextrins, especially by the use of γCD. The CoQ10 gCD complex reveals excellent pharmacokinetic properties not only significantly higher area under the CoQ10 concentration curve in blood plasma from time 0-48 hr (AUC) and higher maximum plasma concentration (Cmax), but also the mean plasma levels even after 24 and 48 hours tended to be significantly higher after CoQ10 gCD complex administration to healthy adult volunteers when compared with CoQ10 formulated in microcrystalline cellulose and administrated in the same way as the complex . We found that this long-lasting high CoQ10 concentration in plasma provides various health benefits. The proven benefits are: 1) Curative effects on damaged human skins by aging, UV and other pollutants in the air, 2) Anti-oxidant activity (study on the reduction of 8-hydroxy-2-deoxy guanosine (8-OHdG) in urine), 3) Muscle augmentation and protection activity (study on the reduction of myogenic enzymes, Creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH)). Furthermore, some combinations of CoQ10-γCD complex with other functional ingredients in formulation are suggested with following claims for anti-aging and health improvements: 1) Analgesic action by reproducing cartilage by the combination with collagen peptide, 2) Anti-fatigue by the enhanced oxidative phosphorylation production of adenosine triphosphate (ATP) by the combination with α-lipoic acid-γCD complex, 3) Antidote against metabolic syndrome by the combination with αCD as a special dietary fiber that shows good effects on controlling body weight, on the ratio of LDLand HDL cholesterol , on the concentration of triglycerides and on the blood sugar level in plasma.
Archive | 2006
Xuyi Gao; Katsunori Nishimura; Fumitoshi Hirayama; Hidetoshi Arima; Kaneto Uekama; Gerhard Schmid; Keiji Terao; Daisuke Nakata; Hiroshi Fukumi
Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences | 2013
Yukiko Uekaji; Ayako Jo; Akihito Urano; Keiji Terao
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2011
Yukiko Uekaji; Daisuke Nakata; Hirokazu Shiga; Ayako Jo; Iwao Tachi; Hiroshi Fukumi; Akihito Urano; Keiji Terao
Archive | 2013
Naoko Ikuta; Yukiko Uekaji; Daisuke Nakata; Keiji Terao; Seiichi Matsugo
日本臨床栄養学会雑誌 | 2011
Naoko Ikuta; Hirokazu Shiga; Yukiko Uekaji; Ayako Jo; Yoshiyuki Ishida; Daisuke Nakata; Kazufumi Kamoi; Masato Nakano; Keiji Terao
Sen-i Gakkaishi | 2010
Kazumasa Hirogaki; Jun Kamitani; Mitsugu Kimizu; Takashi Yamamoto; Eiko Taguchi; Junsho Kanenori; Shinya Kita; Katsuhiko Yoshimoto; Hirokazu Shiga; Keiji Terao; Kenji Hisada; Teruo Hori
Oleoscience | 2015
Shino Takagi; Yoshimi Yoshida; Yoshiyuki Ishida; Keita Sato; Keiji Terao
Archive | 2014
Yukiko Uekaji; Mayu Onishi; Daisuke Nakata; Keiji Terao; Arja Paananen; Riitta Partanen; Hidefumi Yoshii
Archive | 2014
Yuki Naito; Naoko Ikuta; Daisuke Nakata; Keiji Terao; Kinuyo Matsumoto; Naemi Kajiwara; Ayaka Okano; Hiroyuki Yasui; Yutaka Yoshikawa