Keiko Murakoso
Hyogo College of Medicine
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Featured researches published by Keiko Murakoso.
Biochemical and Biophysical Research Communications | 1982
Keiko Yoshida; Shohei Kagawa; Keiko Murakoso; Keiko Nakao; Kunio Haito; Shizuo Shimizu; Akira Matsuoka
Abstract This report describes a beneficial role for 2-deoxy-2-fluoroglucose(2-dfg) in promoting survival of neonatal B cells of the rat. Culturing of islets in medium with 5.5 mM glucose abolished the glucose responsiveness of B cells after 7 days of culture. By contrast, the 2-dfg supplemented culture maintained glucose-induced insulin release, and the recovery of insulin in B cells at day 7 at levels 4 to 7-fold higher than at day 0. Slightly enhanced insulin biosynthesis was observed in those B cells. In addition, a selective deletion of fibroblasts was caused by the addition of the fluoroglucose.
In Vitro Cellular & Developmental Biology – Plant | 1984
Keiko Yoshida; Shohei Kagawa; Keiko Murakoso; Akira Matsuoka
SummaryThe effect of 2-deoxy-d-glucose on maintenance in culture of B cells of the neonatal rat was examined by supplementation of Medium 199 containing 5.5 mM glucose with 1 mM 2-deoxy-d-glucose. Islets maintained in medium with 5.5 mM glucose (basal medium) for 7 d underwent remarkable decreases in glucose sensitivity, and the levels of insulin in the medium dropped. By contrast, addition of 2-deoxy-d-glucose promoted a higher insulin content in medium and an increase in the glucose-induced insulin release and biosynthesis. Moreover, the addition of the deoxysugar caused a selective deletion of fibroblasts and prevented the deterioration of islet cells in basal medium, yielding clusters mostly consisting of islet cells at the end of culture.
The Journal of the Japanese Association for Infectious Diseases | 1994
Shiba Kumar Rai; Hiroshi Shibata; Miyuki Satoh; Keiko Murakoso; Katsumi Sumi; Takashi Kubo; Akira Matsuoka
Chemical & Pharmaceutical Bulletin | 1980
Keiko Murakoso; Yoko Tsumura; Keiko Nakao; Shohei Kagawa; Akira Matsuoka
The Journal of the Japanese Association for Infectious Diseases | 1995
Hiroshi Shibata; Shiba Kumar Rai; Miyuki Satoh; Keiko Murakoso; Katsumi Sumi; Syoji Uga; Takeo Matsumura; Akira Matsuoka
Endocrinologia Japonica | 1982
Keiko Yoshida; Shohei Kagawa; Keiko Murakoso; Kunio Haito; Akira Matsuoka
Archive | 1984
Keiko Yoshida; Shohei Kagawa; Keiko Murakoso; Akira Matsuoka
In Vitro Cellular & Developmental Biology – Plant | 1984
Keiko Yoshida; Shohei Kagawa; Keiko Murakoso; Akira Matsuoka
Chemical & Pharmaceutical Bulletin | 1981
Yoko Tsumura; Keiko Murakoso; Shohei Kagawa; Akira Matsuoka
Endocrinologia Japonica | 1980
Keiko Nakao; Shohei Kagawa; Keiko Murakoso; Mitsuo Hata; Akira Matsuoka