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Dive into the research topics where Keiko Okimura is active.

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Featured researches published by Keiko Okimura.


Chemical & Pharmaceutical Bulletin | 2009

Contribution of Each Amino Acid Residue in Polymyxin B3 to Antimicrobial and Lipopolysaccharide Binding Activity

Kazushi Kanazawa; Yuki Sato; Kazuhiro Ohki; Keiko Okimura; Yoshiki Uchida; Mitsuno Shindo; Naoki Sakura


Bulletin of the Chemical Society of Japan | 2004

The Contribution of the N-Terminal Structure of Polymyxin B Peptides to Antimicrobial and Lipopolysaccharide Binding Activity

Naoki Sakura; Tatsuya Itoh; Yoshiki Uchida; Kazuhiro Ohki; Keiko Okimura; Kenzo Chiba; Yuki Sato; Hiroyuki Sawanishi


Chemical & Pharmaceutical Bulletin | 1991

Structure-Activity Relationships of Rat Neuromedin U for Smooth Muscle Contraction

Naoki Sakura; Satoru Ohta; Yoshiki Uchida; Katsuro Kurosawa; Keiko Okimura; Tadashi Hashimoto


Chemical & Pharmaceutical Bulletin | 1996

Study on surfactin, a cyclic depsipeptide. II. Synthesis of surfactin B2 produced by Bacillus natto KMD 2311.

Sotoo Nagai; Keiko Okimura; Naohito Kaizawa; Kazuhiro Ohki; Shoichi Kanatomo


Chemical & Pharmaceutical Bulletin | 1991

Agonistic and Antagonistic Activities of Neuromedin U-8 Analogs Substituted with Glycine or D-Amino Acid on Contractile Activity of Chicken Crop Smooth Muscle Preparations

Tadashi Hashimoto; Hiroko Masui; Yoshiki Uchida; Naoki Sakura; Keiko Okimura


Chemical & Pharmaceutical Bulletin | 2007

Semi-synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of α, γ-Diaminobutyric Acid Residues

Keiko Okimura; Kazuhiro Ohki; Yuki Sato; Kuniharu Ohnishi; Naoki Sakura


Chemical & Pharmaceutical Bulletin | 2009

Development of des-fatty acyl-polymyxin B decapeptide analogs with Pseudomonas aeruginosa-specific antimicrobial activity.

Naoko Katsuma; Yuki Sato; Kazuhiro Ohki; Keiko Okimura; Kuniharu Ohnishi; Naoki Sakura


Bulletin of the Chemical Society of Japan | 2007

Chemical Conversion of Natural Polymyxin B and Colistin to Their N-Terminal Derivatives

Keiko Okimura; Kazuhiro Ohki; Yuki Sato; Kuniharu Ohnishi; Yoshiki Uchida; Naoki Sakura


Chemical & Pharmaceutical Bulletin | 1992

Contractile Activity of Porcine Neuromedin U-25 and Various Neuromedin U-Related Peptide Fragments on Isolated Chicken Crop Smooth Muscle.

Keiko Okimura; Naoki Sakura; Satoru Ohta; Katsuro Kurosawa; Tadashi Hashimoto


Chemical & Pharmaceutical Bulletin | 2006

Hydrolytic Cleavage of Pyroglutamyl-peptide Bond. V. Selective Removal of Pyroglutamic Acid from Biologically Active Pyroglutamylpeptides in High Concentrations of Aqueous Methanesulfonic Acid

Junko Kobayashi; Kazuhiro Ohki; Keiko Okimura; Tadashi Hashimoto; Naoki Sakura

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